Patents by Inventor Jo Handelsman

Jo Handelsman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200188913
    Abstract: A platform and method for conducting multi-variable combinational interactions are provided. An array of multiplexing chambers in formed in a body. The body also includes a common well communicating with each multiplexing chamber of the array of multiplexing chambers and a plurality of variable wells. Each of variable wells communicates with at least one multiplexing chamber of the array of multiplexing chambers. The common well is loaded with a first variable and different variables are loaded in each of the plurality of variable wells. The interaction of the first variable with at least one of the different variables in each multiplexing chamber of the array of multiplexing chambers is observed.
    Type: Application
    Filed: December 12, 2018
    Publication date: June 18, 2020
    Inventors: David J. Beebe, Duane S. Juang, jiaquan Yu, Jo Handelsman
  • Patent number: 8759031
    Abstract: Novel extender units for Type I polyketide synthases are provided. Also provided are genes, compounds, and methods for generating these units, and for incorporation of the novel extender units into polyketides for the purpose of generating new structural derivatives of polyketide-containing products.
    Type: Grant
    Filed: April 9, 2008
    Date of Patent: June 24, 2014
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Michael G. Thomas, Jo Handelsman, Yolande Alia Chan, Angela M. Podevels
  • Publication number: 20080254508
    Abstract: Novel extender units for Type I polyketide synthases are provided. Also provided are genes, compounds, and methods for generating these units, and for incorporation of the novel extender units into polyketides for the purpose of generating new structural derivatives of polyketide-containing products.
    Type: Application
    Filed: April 9, 2008
    Publication date: October 16, 2008
    Inventors: Michael G. Thomas, Jo Handelsman, Yolande Alia Chan, Angela M. Podevels
  • Publication number: 20060205017
    Abstract: The present invention provides methods and compositions for accessing, in a generally unbaised manner, a diverse genetic pool for genes involved in biosynthetic pathways. The invention also provides compounds which can be identified by cloning biosynthetic pathways.
    Type: Application
    Filed: March 6, 2006
    Publication date: September 14, 2006
    Inventors: Jo Handelsman, Robert Goodman, Michelle Rondon
  • Publication number: 20060052425
    Abstract: The present invention provides compositions and methods for modulating bacterial quorum sensing using antagonist or agonist compounds. Further, the present invention provides methods of treating or preventing microbial damages and diseases, in particular for diseases where there is an advantage in inhibiting quorum sensing regulated phenotypes of pathogens.
    Type: Application
    Filed: March 23, 2005
    Publication date: March 9, 2006
    Applicant: WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: Jo Handelsman, Bradley Borlee
  • Patent number: 7008767
    Abstract: The present invention provides methods and composition for accessing, in a generally unbaised manner, a diverse genetic pool for genes involved in biosynthetic pathways. The invention also provides compounds which can be identified by cloning biosynthetic pathways.
    Type: Grant
    Filed: June 8, 2001
    Date of Patent: March 7, 2006
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Jo Handelsman, Robert M. Goodman, Michelle R. Rondon
  • Publication number: 20050084878
    Abstract: Methods and reagents for isolating polynucleotide molecules from uncultured microbial cells in an environmental sample, the method comprising: obtaining uncultured microbial cells from the sample, dispersing the cells from each other and from other components in the sample, purifying the dispersed cells via discontinuous gradient centrifugation wherein the cells are collected in an interface of the gradient, embedding the cells in agarose gel, to produce agarose gel blocks containing the cells, and lysing the cells within the agarose gel blocks, thereby releasing high molecular weight polynucleotide molecules from the cells.
    Type: Application
    Filed: May 17, 2004
    Publication date: April 21, 2005
    Applicant: Wisconsin Alumni Research Foundation
    Inventors: Mark Liles, Robert Goodman, Lynn Williamson, Jo Handelsman
  • Patent number: 6602712
    Abstract: A enterotoxin-deficient mutant of a member strain of the Bacillus cereus group does not produce HBL enterotoxin, which has been regarded as a human pathogen found in member strains. An enterotoxin-deficient mutant is suitable for use as a biocontrol agent. Methods for making the mutant and for using the mutant are described.
    Type: Grant
    Filed: April 7, 1999
    Date of Patent: August 5, 2003
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Jo Handelsman, Amy K. Klimowicz
  • Publication number: 20020151071
    Abstract: A enterotoxin-deficient mutant of a member strain of the Bacillus cereus group does not produce HBL enterotoxin, which has been regarded as a human pathogen found in member strains. An enterotoxin-deficient mutant is suitable for use as a biocontrol agent. Methods for making the mutant and for using the mutant are described.
    Type: Application
    Filed: April 7, 1999
    Publication date: October 17, 2002
    Inventors: JO HANDELSMAN, AMY K. KLIMOWICZ
  • Publication number: 20020045177
    Abstract: The present invention provides methods and composition for accessing, in a generally unbaised manner, a diverse genetic pool for genes involved in biosynthetic pathways. The invention also provides compounds which can be identified by cloning biosynthetic pathways.
    Type: Application
    Filed: June 8, 2001
    Publication date: April 18, 2002
    Inventors: Jo Handelsman, Robert M. Goodman, Michelle R. Rondon
  • Patent number: 6261842
    Abstract: The present invention provides methods and compositions for accessing, in a generally unbaised manner, a diverse genetic pool for genes involved in biosynthetic pathways. The invention also provides compounds which can be identified by cloning biosynthetic pathways.
    Type: Grant
    Filed: November 13, 1997
    Date of Patent: July 17, 2001
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Jo Handelsman, Robert M. Goodman, Michelle R. Rondon
  • Patent number: 6033659
    Abstract: A novel strain of Bacillus cereus, designated W35 is useful as a biocontrol agent to combat fungal damping off disease in field crop plants. W35 produces the antibiotic zwittermicin A. Strain W35 is distinguished from other zwittermicin-producing Bacillus cereus strains by resistance to phage P7, antibiotic resistance, and colony morphology.
    Type: Grant
    Filed: May 27, 1998
    Date of Patent: March 7, 2000
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Jo Handelsman, Sandra J Stewart, Eric V Stabb
  • Patent number: 6034124
    Abstract: A biocontrol bacteria, Bacillus cereus ATCC 53522, has been found to naturally synthesize two antibiotics, here designated zwittermicin A and antibiotic B. Zwittermicin A is a 396 dalton linear aminopolyol, a class of metabolite previously unknown in B. cereus. Antibiotic B is an aminoglycoside. Both antibiotics exhibit inhibitory activity on many fungal and bacterial pathogens.
    Type: Grant
    Filed: December 16, 1998
    Date of Patent: March 7, 2000
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Jo Handelsman, Laura Silo-Suh, Jon Clardy, Haiyin He
  • Patent number: 6030610
    Abstract: A novel strain of Bacillus cereus, designated Z8 is useful as a biocontrol agent to combat fungal damping off disease in field crop plants. Z8 produces the antibiotic zwittermicin A. Strain Z8 is distinguished from other zwittermicin-producing Bacillus cereus strains by resistance to phage P7, antibiotic resistance, and colony morphology.
    Type: Grant
    Filed: May 27, 1998
    Date of Patent: February 29, 2000
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Jo Handelsman, Sandra J Stewart, Eric V Stabb
  • Patent number: 5998196
    Abstract: A novel strain of Bacillus cereus, designated SOY130 ATCC 202076 is useful as a biocontrol agent to combat fungal damping off disease in field crop plants. SOY130 produces the antibiotic zwittermicin A. Strain SOY130 is distinguished from other zwittermicin-producing Bacillus cereus strains by resistance to streptomycin and neomycin.
    Type: Grant
    Filed: May 27, 1998
    Date of Patent: December 7, 1999
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Jo Handelsman, Sandra J Stewart, Eric V Stabb
  • Patent number: 5852054
    Abstract: A biocontrol bacteria, Bacillus cereus ATCC 53522, has been found to naturally synthesize two antibiotics, here designated zwittermicin A and antibiotic B. Zwittermicin A is a 396 dalton linear aminopolyol, a class of metabolite previously unknown in B. cereus. Antibiotic B is an aminoglycoside. Both antibiotics exhibit inhibitory activity on many fungal and bacterial pathogens.
    Type: Grant
    Filed: March 8, 1994
    Date of Patent: December 22, 1998
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Jo Handelsman, Laura Silo-Suh, Jon Clardy, Haiyin He
  • Patent number: 5736382
    Abstract: A novel strain of Bacillus cereus, designated DGA34, has been isolated from the environment. The strain DGA34 is one of a number of B. cereus strains which are useful as biocontrol agents to combat fungal damping off disease in field crop plants, in part because of their production of the antibiotic zwittermicin A. Strain DGA34 has exhibited the best performance among a large number of natural isolates in producing the highest titer of zwittermicin A production.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: April 7, 1998
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Jo Handelsman, Lynn M. Jacobson, Eric V. Stabb
  • Patent number: 5700462
    Abstract: A novel strain of Bacillus cereus, designated MS1-9, has been isolated from the environment. The strain MS1-9, ATCC 55812, is one of a number of B. cereus strains which are useful as biocontrol agents to combat fungal damping off disease in field crop plants, and strain MS1-9 has exhibited good performance under high disease pressure among a large number of natural isolates in fostering the emergence and growth of alfalfa plants under normal field conditions in the upper midwestern U.S.
    Type: Grant
    Filed: November 12, 1996
    Date of Patent: December 23, 1997
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Jo Handelsman, Eric V. Stabb, Lynn M. Jacobson, Robert M. Goodman, David W. Johnson, Kevin P. Smith
  • Patent number: 5695982
    Abstract: Biocontrol strains of the bacterial species Bacillus cereus have been previously identified as having use in aiding the growth of crop plants, but have suffered from inconsistent performance on alfalfa. It has been found that biocontrol B. cereus strains are inhibited by canavanine, an analogue of arginine exuded by alfalfa seeds. It has also been found that canavanine resistant mutant strains of B. cereus biocontrol strains can readily be made in culture which exhibit the ability to grow in the presence of alfalfa seed and inhibit Pythium pathogenesis.
    Type: Grant
    Filed: August 29, 1996
    Date of Patent: December 9, 1997
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Jo Handelsman, Jocelyn Louise Milner, Elizabeth Anne Blackson
  • Patent number: 5618692
    Abstract: A new gene from Bacillus cereus has been characterized which codes for a protein conferring resistance to the antibiotic zwittermicin A produced by some strains of the bacteria. The resistance gene, designated zmaR, is found to be present in almost all strains of the bacteria which are known to natively have the ability to synthesize zwittermicin A, and thus allows tests for the presence of the gene to serve as a test to be used with new strains to assay for zwittermicin A production. The gene also has use in increasing production of the antibiotic by producing strains.
    Type: Grant
    Filed: September 12, 1994
    Date of Patent: April 8, 1997
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Jo Handelsman, Jocelyn L. Milner, Elizabeth A. Stohl, Sandra J. Stewart, Eric Stabb