Patents by Inventor JOËL ROUSSEAU

JOËL ROUSSEAU has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • APP MODIFICATION VIA BASE EDITING USING THE CRISPR/CAS9 SYSTEM
    Publication number: 20220033846
    Abstract: Methods and products (e.g., guide RNAs or pegRNA and recombinant proteins) are described for decreasing amyloidogenic A? peptide levels produced by a cell, or the aggregation of the A? peptide, as well as uses of such methods and products, for example for the treatment of Alzheimer's disease and/or age-related cognitive decline in a subject in need thereof.
    Type: Application
    Filed: December 20, 2019
    Publication date: February 3, 2022
    Inventors: Jacques P. TREMBLAY, Joël ROUSSEAU, Antoine GUYON
  • CRISPR-based methods and products for increasing frataxin levels and uses thereof
    Patent number: 10323073
    Abstract: Methods and products (e.g., gRNAs, recombinant fusion proteins, frataxin targeting systems, compositions and kits) are described for increasing frataxin expression/levels in a cell, as well as uses of such methods and products, for example for the treatment of Friedreich ataxia in a subject suffering therefrom.
    Type: Grant
    Filed: March 20, 2015
    Date of Patent: June 18, 2019
    Assignee: UNIVERSITÉ LAVAL
    Inventors: Jacques P. Tremblay, Pierre Chapdelaine, Joël Rousseau
  • Reduction of amyloid beta peptide production via modification of the APP gene using the CRISPR/Cas system
    Patent number: 10280419
    Abstract: Methods and products are described related to use of the CRISPR/Cas9 system to introduce a modification into an APP gene, such as guide RNAs and recombinant proteins, for decreasing amyloid beta peptide produced by a cell. Also described are uses of such methods and products for the treatment of Alzheimer's disease and/or age-related cognitive decline in a cell from a subject in need thereof.
    Type: Grant
    Filed: May 8, 2015
    Date of Patent: May 7, 2019
    Assignee: UNIVERSITÉ LAVAL
    Inventors: Jacques P. Tremblay, Joël Rousseau, Pierre Chapdelaine
  • CRISPR-BASED METHODS AND PRODUCTS FOR INCREASING FRATAXIN LEVELS AND USES THEREOF
    Publication number: 20180170985
    Abstract: Methods and products (e.g., gRNAs, recombinant fusion proteins, frataxin targeting systems, compositions and kits) are described for increasing frataxin expression/levels in a cell, as well as uses of such methods and products, for example for the treatment of Friedreich ataxia in a subject suffering therefrom.
    Type: Application
    Filed: March 20, 2015
    Publication date: June 21, 2018
    Inventors: JACQUES P. TREMBLAY, PIERRE CHAPDELAINE, JOÈL ROUSSEAU
  • METHODS AND PRODUCTS FOR INCREASING FRATAXIN LEVELS AND USES THEREOF
    Publication number: 20170320968
    Abstract: Methods and products (e.g., recombinant proteins) are described for increasing frataxin expression/levels in a cell, as well as uses of such methods and products, for example for the treatment of Friedreich ataxia in a subject suffering therefrom.
    Type: Application
    Filed: June 12, 2017
    Publication date: November 9, 2017
    Inventors: JACQUES P. TREMBLAY, JOEL ROUSSEAU, PIERRE CHAPDELAINE, ZOE COULOMBE
  • PREVENTION AND TREATMENT OF ALZHEIMER'S DISEASE BY GENOME EDITING USING THE CRISPR/CAS SYSTEM
    Publication number: 20170240888
    Abstract: Methods and products related to genome editing using the CRISPR/Cas9 system to introduce an A673T substitution into an APP gene, such as guide RNAs and recombinant proteins, are described for decreasing APP levels produced by a cell, and use for the treatment of Alzheimer's disease and/or age-related cognitive decline in a cell from a subject in need thereof.
    Type: Application
    Filed: May 8, 2015
    Publication date: August 24, 2017
    Inventors: JACQUES P. TREMBLAY, JOËL ROUSSEAU, PIERRE CHAPDELAINE
  • Methods and products for increasing frataxin levels and uses thereof
    Patent number: 9708414
    Abstract: Methods and products (e.g., recombinant proteins) are described for increasing frataxin expression/levels in a cell, as well as uses of such methods and products, for example for the treatment of Friedreich ataxia in a subject suffering therefrom.
    Type: Grant
    Filed: November 16, 2012
    Date of Patent: July 18, 2017
    Assignee: UNIVERSITÉ LAVAL
    Inventors: Jacques P. Tremblay, Joel Rousseau, Pierre Chapdelaine, Zoe Coulombe
  • METHODS AND PRODUCTS FOR INCREASING FRATAXIN LEVELS AND USES THEREOF
    Publication number: 20140315782
    Abstract: Methods and products (e.g., recombinant proteins) are described for increasing frataxin expression/levels in a cell, as well as uses of such methods and products, for example for the treatment of Friedreich ataxia in a subject suffering therefrom.
    Type: Application
    Filed: November 16, 2012
    Publication date: October 23, 2014
    Inventors: Jacques P. Tremblay, Joel Rousseau, Pierre Chapdelaine, Zoe Coulombe