Patents by Inventor Joël Vandkerckhove

Joël Vandkerckhove has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Reversed mammalian protein-protein interaction trap
    Publication number: 20100174049
    Abstract: The invention relates to a recombinant receptor, comprising a ligand-binding domain and a signaling domain that comprises a heterologous bait polypeptide, which receptor is inactivated by binding of a prey polypeptide to the heterologous bait peptide, either in presence or absence of a ligand binding to the ligand-binding domain. The receptor is activated by addition of a compound that disrupts the bait-prey interaction. The invention also relates to a method of screening compounds that disrupt compound-compound binding using the recombinant receptor.
    Type: Application
    Filed: December 14, 2009
    Publication date: July 8, 2010
    Applicant: Vlaams Interuniversitair Instituut Voor Biotechnologie VZW
    Inventors: Sven Eyckerman, Jan Tavernier, Joël Vandkerckhove