Patents by Inventor João Carlos Ramos Damil

João Carlos Ramos Damil has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antibacterial quinolines
    Publication number: 20230106913
    Abstract: The present disclosure relates to 6-substituted quinoline-2-piperidine derivatives for use in the treatment and/or prevention of tuberculosis.
    Type: Application
    Filed: December 28, 2020
    Publication date: April 6, 2023
    Inventors: Augusto Eugénio PARDAL FILIPE, Carla Patrícia DA COSTA PEREIRA ROSA, Ana Vanessa CORDEIRO SIMÕES, João Carlos RAMOS DAMIL, João Pedro SILVA SERRA, Ana Lúcia ALMEIDA FERREIRA, Rita Isabel GOMES NEVES, Sara Alexandra MARQUES HOMEM E SOUSA DOS SANTOS
  • Processes for the preparation of pharmaceutically acceptable salts of (R)-Pirlindole and (S)-Pirlindole
    Patent number: 11008328
    Abstract: The present invention relates to an improved process for the preparation of Pirlindole enantiomers, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: April 20, 2018
    Date of Patent: May 18, 2021
    Assignee: TECNIMEDE, SOCIEDADE TÉCNICO-MEDICINAL, SA
    Inventors: Carla Patrícia Da Costa Pereira Rosa, João Carlos Ramos Damil, Ana Vanessa Cordeiro Simões, João Pedro Silva Serra
  • Processes for the preparation of pharmaceutically acceptable salts of (R)-Pirlindole and (S)-Pirlindole
    Patent number: 11008327
    Abstract: The present disclosure relates to an improved process for the synthesis of piperazine ring, particularly for the preparation of heterocyclic compounds useful as intermediates in the synthesis of pyrazinocarbazoles such as the antidepressant Pirlindole. The process described is useful to prepare Pirlindole enantiomers, or a pharmaceutically accepted salt thereof.
    Type: Grant
    Filed: April 20, 2018
    Date of Patent: May 18, 2021
    Assignee: TECNIMEDE, SOCIEDADE TÉCNICO-MEDICINAL, SA
    Inventors: Carla Patrícia Da Costa Pereira Rosa, João Carlos Ramos Damil, Ana Vanessa Cordeiro Simões, João Pedro Silva Serra
  • PROCESS FOR THE PREPARATION OF PIRLINDOLE ENANTIOMERS AND ITS SALTS
    Publication number: 20200190098
    Abstract: The present invention relates to an improved process for the preparation of Pirlindole enantiomers, or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: April 20, 2018
    Publication date: June 18, 2020
    Inventors: Carla Patrícia DA COSTA PEREIRA ROSA, João Carlos RAMOS DAMIL, Ana Vanessa CORDEIRO SIMÕES, João Pedro SILVA SERRA
  • PROCESS FOR THE PREPARATION OF PIPERAZINE RING FOR THE SYNTHESIS OF PYRAZINOCARBAZOLE DERIVATIVES
    Publication number: 20200131186
    Abstract: The present disclosure relates to an improved process for the synthesis of piperazine ring, particularly for the preparation of heterocyclic compounds useful as intermediates in the synthesis of pyrazinocarbazoles such as the antidepressant Pirlindole. The process described is useful to prepare Pirlindole enantiomers, or a pharmaceutically accepted salt thereof.
    Type: Application
    Filed: April 20, 2018
    Publication date: April 30, 2020
    Inventors: Carla Patrícia DA COSTA PEREIRA ROSA, João Carlos RAMOS DAMIL, Ana Vanessa CORDEIRO SIMÕES, João Pedro SILVA SERRA
  • (R)-pirlindole and its pharmaceutically acceptable salts for use in medicine
    Patent number: 10533012
    Abstract: (R)-pirlindole or its pharmaceutically acceptable salts, as well as pharmaceutical compositions comprising the same for use in the therapeutic treatment and prevention of pain.
    Type: Grant
    Filed: December 19, 2017
    Date of Patent: January 14, 2020
    Assignee: TECNIMEDE SOCIEDADE TECNICO-MEDICINAL S.A.
    Inventors: Augusto Eugénio Pardal Filipe, Pedro Filipe Eufrásio Pedroso, Susana Marques Almeida Pecorelli, Carlos Alberto Eufrásio Casimiro Caixado, Ana Sofia da Conceição Lopes, João Carlos Ramos Damil
  • Pharmaceutically acceptable salts of pirlindole enantiomers for use in medicine
    Patent number: 10226460
    Abstract: The present invention provides pharmaceutically acceptable salts of enantiomerically pure (R)-pirlindole and (S)-pirlindole compounds having an increased bioavailability profile for use in medicine.
    Type: Grant
    Filed: May 9, 2014
    Date of Patent: March 12, 2019
    Assignee: TECNIMEDE SOCIEDADE TECNICO-MEDICINAL S.A.
    Inventors: Augusto Eugenio Pardal Filipe, Pedro Filipe Eufrasio Pedroso, Susana Marques Almeida Pecorelli, Carlos Alberto Eufrasio Casimiro Caixado, Ana Sofia da Conceicao Lopes, Joao Carlos Ramos Damil, Pedro Paulo de Lacerda E Oliveira Santos
  • (R)-PIRLINDOLE AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS FOR USE IN MEDICINE
    Publication number: 20180111944
    Abstract: (R)-pirlindole or its pharmaceutically acceptable salts, as well as pharmaceutical compositions comprising the same for use in the therapeutic treatment and prevention of pain.
    Type: Application
    Filed: December 19, 2017
    Publication date: April 26, 2018
    Applicant: Tecnimede Sociedade Tecnico-Medicinal S.A.
    Inventors: Augusto Eugénio Pardal Filipe, Pedro Filipe Eufrásio Pedroso, Susana Marques Almeida Pecorelli, Carlos Alberto Eufrásio Casimiro Caixado, Ana Sofia da Conceição Lopes, João Carlos Ramos Damil
  • Process for obtaining optically active pirlindole enantiomers and salts thereof
    Patent number: 9682986
    Abstract: The present invention provides a new process for obtaining optically active pirlindole enantiomers, in the form of a free base or in the form of pharmaceutically acceptable salts. The products obtained according to the present invention are enantiomerically pure and are useful in medicine.
    Type: Grant
    Filed: May 9, 2014
    Date of Patent: June 20, 2017
    Assignee: TECNIMEDE SOCIEDADE TECNICO-MEDICINAL S.A.
    Inventors: Augusto Eugenio Pardal Filipe, Pedro Filipe Eufrasio Pedroso, Susana Marques Almeida Pecorelli, Carlos Alberto Eufrasio Casimiro Caixado, Ana Sofia da Conceicao Lopes, Joao Carlos Ramos Damil, Pedro Paulo de Lacerda E Oliveira Santos
  • PHARMACEUTICALLY ACCEPTABLE SALTS OF PIRLINDOLE ENANTIOMERS FOR USE IN MEDICINE
    Publication number: 20170143710
    Abstract: The present invention provides pharmaceutically acceptable salts of enantiomerically pure (R)-pirlindole and (S)-pirlindole compounds having an increased bioavailability profile for use in medicine.
    Type: Application
    Filed: May 9, 2014
    Publication date: May 25, 2017
    Applicant: TECNIMEDE SOCIEDADE TECNICO-MEDICINAL S.A.
    Inventors: Augusto Eugenio PARDAL FILIPE, Pedro Filipe EUFRASIO PEDROSO, Susana Marques ALMEIDA PECORELLI, Carlos Alberto Eufrasio CASIMIRO CAIXADO, Ana Sofia da Conceicao LOPES, Joao Carlos Ramos DAMIL, Pedro Paulo de Lacerda E OLIVEIRA SANTOS
  • (R)-PIRLINDOLE AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS FOR USE IN MEDICINE
    Publication number: 20170145015
    Abstract: (R)-pirlindole or its pharmaceutically acceptable salts, as well as pharmaceutical compositions comprising the same for use in the therapeutic treatment and prevention of pain.
    Type: Application
    Filed: May 9, 2014
    Publication date: May 25, 2017
    Applicant: TECNIMEDE SOCIEDADE TECNICO-MEDICINAL S.A.
    Inventors: Augusto Eusebio PARDAL FILIPE, Pedro Filipe EUFRASIO PEDROSO, Susana Marques ALMEIDA PECORELLI, Carlos Alberto Eufrasio CASIMIRO CAIXADO, Ana Sofia da Conceiçao LOPES, Joao Carlos Ramos DAMIL
  • PROCESS FOR OBTAINING OPTICALLY ACTIVE PIRLINDOLE ENANTIOMERS AND SALTS THEREOF
    Publication number: 20170145024
    Abstract: The present invention provides a new process for obtaining optically active pirlindole enantiomers, in the form of a free base or in the form of pharmaceutically acceptable salts. The products obtained according to the present invention are enantiomerically pure and are useful in medicine.
    Type: Application
    Filed: May 9, 2014
    Publication date: May 25, 2017
    Applicant: TECNIMEDE SOCIEDADE TECNICO-MEDICINAL S.A.
    Inventors: Augusto Eugenio PARDAL FILIPE, Pedro Filipe EUFRASIO PEDROSO, Susana Marques ALMEIDA PECORELLI, Carlos Alberto Eufrasio CASIMIRO CAIXADO, Ana Sofia da Conceicao LOPES, Joao Carlos Ramos DAMIL, Pedro Paulo de Lacerda E OLIVEIRA SANTOS
  • 2,3,4,5-tetrahydroxy-6-sulfooxy hexanoic acid, pharmaceutically acceptable salts and equilibrium forms thereof, processes for their preparation, pharmaceutical compositions comprising such compounds and their medical use
    Patent number: 8017650
    Abstract: The invention relates to novel compounds of general formula I wherein M represents hydrogen, or a metallic cation, preferably an alkaline metal, or alkaline-earth metal, and n is equal to 1, 2 or 3. The present invention also comprises compounds of general formula I in their equilibrium forms, including lactonic forms, their enantiomers in pure form, or in an enriched form in one of the optical isomers, racemic mixtures, diastereomers and solvates thereof. The present invention further relates to processes for the preparation of compounds of general formula I, to pharmaceutical compositions comprising compounds of general formula I as only active ingredient, or in association with other active ingredients. Another aspect of the invention is the use of compounds of general formula I for the treatment of dyslipidemia, associated, or not, to other metabolic disorders, such as glucose intolerance syndrome and type 1 or 2 diabetes mellitus, by means of isolated administration or combined with other substances.
    Type: Grant
    Filed: November 15, 2006
    Date of Patent: September 13, 2011
    Inventors: Jorge Ruas Da Silva, Ana Maria Staack Reis Machado, Joaquim Alberto Barros Pereira, Joao Carlos Ramos Damil, Carlos Alberto Casimiro Caixado, Augusto Eugenio Pardal Filipe
  • 2,3,4,5-Tetrahydroxy-6-Sulfooxy Hexanoic Acid, Pharmaceutically Acceptable Salts and Equilibrium Forms Thereof, Processes for Their Preparation, Pharmaceutical Compositions Comprising Such Compounds and Their Medical Use
    Publication number: 20080279808
    Abstract: The invention relates to novel compounds of general formula I wherein M represents hydrogen, or a metallic cation, preferably an alkaline metal, or alkaline-earth metal, and n is equal to 1, 2 or 3. The present invention also comprises compounds of general formula I in their equilibrium forms, including lactonic forms, their enantiomers in pure form, or in an enriched form in one of the optical isomers, racemic mixtures, diastereomers and solvates thereof. The present invention further relates to processes for the preparation of compounds of general formula I, to pharmaceutical compositions comprising compounds of general formula I as only active ingredient, or in association with other active ingredients. Another aspect of the invention is the use of compounds of general formula I for the treatment of dyslipidemia, associated, or not, to other metabolic disorders, such as glucose intolerance syndrome and type 1 or 2 diabetes mellitus, by means of isolated administration or combined with other substances.
    Type: Application
    Filed: November 15, 2006
    Publication date: November 13, 2008
    Inventors: Jorge Ruas Da Silva, Ana Maria Staack Reis Machado, Joaquim Alberto Barros Pereira, Joao Carlos Ramos Damil, Carlos Alberto Casimiro Caixado, Augusto Eugenio Pardal Filipe