Patents by Inventor João Manuel De Oliveira Garcia Da Fonseca

João Manuel De Oliveira Garcia Da Fonseca has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210063303
    Abstract: A detection system including a detection device and an assay device. The detection device includes a space for receiving an assay device, a drive arrangement engaging the assay device to rotate the assay device, a light source arranged to direct light towards the assay device, and a diffuser arranged to diffuse light from the light source. The diffuser is arranged between the light source and the space. The detection device includes a light receiver arranged to receive light from the light source that has passed through the assay device.
    Type: Application
    Filed: September 4, 2018
    Publication date: March 4, 2021
    Applicant: BIOSURFIT, S.A.
    Inventors: José PEDRO SANTOS MANSO CÔRTE-REAL, José MIGUEL SILVA DO CARMO NOGUEIRA, André MIGUEL ALVES FARINHA, Alberto EDUARDO ARTILHEIRO FERREIRA, Tiago FILIPE PINTO SILVA, Mauro MIGUEL MELO RIBEIRO, Filipe DA CONCEIÇÃO FERNANDES THOMAZ,, João MANUEL DE OLIVEIRA GARCIA DA FONSECA,
  • Publication number: 20200209146
    Abstract: A detection system including a detection device and an assay device. The detection device includes a space for receiving an assay device, a drive arrangement engaging the assay device to rotate the assay device, a light source arranged to direct light towards the assay device, and a diffuser arranged to diffuse light from the light source. The diffuser is arranged between the light source and the space. The detection device includes a light receiver arranged to receive light from the light source that has passed through the assay device.
    Type: Application
    Filed: September 4, 2018
    Publication date: July 2, 2020
    Applicant: BIOSURFIT, S.A.
    Inventors: Sandro MIGUEL PINTO BORDEIRA, Mauro MIGUEL MELO RIBEIRO, Miguel TAVARES ALELUIA, Rui MIGUEL AFONSO GOMES DA FONSECA,, Tiago FILIPE PINTO SILVA, Milton JOSÉ SANTOS FERNANDES, Filipe DA CONCEIÇÃO FERNANDES THOMAZ,, João MANUEL DE OLIVEIRA GARCIA DA FONSECA,
  • Patent number: 10684206
    Abstract: Systems and methods for classifying blood cells in a blood sample are disclosed. A series of frames of the blood sample as it flows through a field of view of an image capture device are captured and analysed. Advantageously, the disclosed systems and methods combine the availability of morphological cell data with the convenience of a flow-through arrangement. The classification results can be used for estimating cell counts in a blood sample.
    Type: Grant
    Filed: September 29, 2015
    Date of Patent: June 16, 2020
    Assignee: Biosurfit, S.A.
    Inventors: Francisco Correia De Matos Nolasco Lamas, João Manuel De Oliveira Garcia Da Fonseca, André Do Rosário Magalhães, José Pedro Santos Manso Co̊rte-Real, Ricardo Manuel Marques Caleiro Cabeça
  • Patent number: 10684207
    Abstract: Systems and methods for classifying blood cells in a blood sample are disclosed. A series of frames of the blood sample as it flows through a field of view of an image capture device are captured and analysed. Advantageously, the disclosed systems and methods combine the availability of morphological cell data with the convenience of a flow-through arrangement. The classification results can be used for estimating cell counts in a blood sample.
    Type: Grant
    Filed: March 29, 2018
    Date of Patent: June 16, 2020
    Assignee: Biosurfit, S.A.
    Inventors: Francisco Correia De Matos Nolasco Lamas, João Manuel De Oliveira Garcia Da Fonseca, André Do Rosário Magalhães, José Pedro Santos Manso Côrte-Real, Ricardo Manuel Marquest Caleiro Cabeca
  • Patent number: 10337982
    Abstract: Methods for determining a sample concentration of target entities in a sample, for example, determining a concentration of target antigens or antibodies in a blood sample or other biological sample.
    Type: Grant
    Filed: July 25, 2017
    Date of Patent: July 2, 2019
    Assignee: Biosurfit, S.A.
    Inventor: João Manuel de Oliveira Garcia Da Fonseca
  • Patent number: 10330589
    Abstract: Methods for determining a sample concentration of target entities in a sample, for example, determining a concentration of target antigens or antibodies in a blood sample or other biological sample.
    Type: Grant
    Filed: March 22, 2018
    Date of Patent: June 25, 2019
    Assignee: Biosurfit, S.A.
    Inventor: João Manuel de Oliveira Garcia Da Fonseca
  • Patent number: 10307756
    Abstract: A microfluidic device with reduced risk of bubble formation at a capillary junction between two conduits is provided. In some embodiments, the microfluidic device comprises a supply reservoir, a first conduit and a second conduit. The first conduit is configured such that liquid flows by capillary effect from the supply reservoir into the first conduit. The second conduit is connected to the first conduit through an opening in a wall of the first conduit and is configured such that liquid flows from the first conduit to the second conduit by capillary effect. A width of the second conduit, along a direction of liquid flow in the first conduit, is greater than a depth of the second conduit and a depth of the second conduit is less than a depth of the first conduit.
    Type: Grant
    Filed: March 22, 2018
    Date of Patent: June 4, 2019
    Assignee: Biosurfit, S.A.
    Inventors: Ricardo Manuel Marques Caleiro Cabeça, André Do Rosário Magalhães, Andreia Andrade Dos Santos, Sandra Cristina Sarmento Donato Dos Santos E Silva, João Manuel De Oliveira Garcia Da Fonseca
  • Publication number: 20180217043
    Abstract: Systems and methods for classifying blood cells in a blood sample are disclosed. A series of frames of the blood sample as it flows through a field of view of an image capture device are captured and analysed. Advantageously, the disclosed systems and methods combine the availability of morphological cell data with the convenience of a flow-through arrangement. The classification results can be used for estimating cell counts in a blood sample.
    Type: Application
    Filed: March 29, 2018
    Publication date: August 2, 2018
    Inventors: Francisco CORREIA DE MATOS NOLASCO LAMAS, João MANUEL DE OLIVEIRA GARCIA DA FONSECA, André DO ROSÁRIO MAGALHÃES, José PEDRO SANTOS MANSO CÔRTE-REAL, Ricardo Manuel Marquest Caleiro CABECA
  • Publication number: 20180207636
    Abstract: A microfluidic device with reduced risk of bubble formation at a capillary junction between two conduits is provided. In some embodiments, the microfluidic device comprises a supply reservoir, a first conduit and a second conduit. The first conduit is configured such that liquid flows by capillary effect from the supply reservoir into the first conduit. The second conduit is connected to the first conduit through an opening in a wall of the first conduit and is configured such that liquid flows from the first conduit to the second conduit by capillary effect. A width of the second conduit, along a direction of liquid flow in the first conduit, is greater than a depth of the second conduit and a depth of the second conduit is less than a depth of the first conduit.
    Type: Application
    Filed: March 22, 2018
    Publication date: July 26, 2018
    Inventors: Ricardo Manuel MARQUES CALEIRO CABEÇA, André DO ROSÁRIO MAGALHÃES, Andreia ANDRADE DOS SANTOS, Sandra Cristina SARMENTO DONATO DOS SANTOS E SILVA, João Manuel DE OLIVEIRA GARCIA DA FONSECA
  • Publication number: 20180209896
    Abstract: Methods for determining a sample concentration of target entities in a sample, for example, determining a concentration of target antigens or antibodies in a blood sample or other biological sample.
    Type: Application
    Filed: March 22, 2018
    Publication date: July 26, 2018
    Inventor: João Manuel de Oliveira Garcia Da Fonseca
  • Patent number: 9933348
    Abstract: A device is disclosed for centrifugally driving liquid flow to sequentially dispense aliquots from a reservoir while the device rotates. Also disclosed is a method and system for analyzing a liquid to derive an indicator of sedimentation rate of the liquid using sequential aliquoting, using the disclosed device in some embodiments. A particular application is the analysis of blood samples, including sedimentation rate and hematocrit.
    Type: Grant
    Filed: December 7, 2012
    Date of Patent: April 3, 2018
    Assignee: Biosurfit, S.A.
    Inventors: Nuno Alexandre Esteves Reis, Joao Manuel De Oliveira Garcia Da Fonseca
  • Publication number: 20180085754
    Abstract: A microfluidic device with reduced risk of bubble formation at a capillary junction between two conduits is provided. The microfluidic device can include a supply reservoir, a first conduit and a second conduit. The first conduit is configured such that liquid flows by capillary effect from the supply reservoir into the first conduit. The second conduit is connected to the first conduit through an opening in a wall of the first conduit and is configured such that liquid flows from the first conduit to the second conduit by capillary effect. A width of the second conduit, along a direction of liquid flow in the first conduit, is greater than a depth of the second conduit and a depth of the second conduit is less than a depth of the first conduit.
    Type: Application
    Filed: June 17, 2016
    Publication date: March 29, 2018
    Applicant: BIOSURFIT, S.A.
    Inventors: Ricardo Manuel MARQUES CALEIRO CABEÇA, André DO ROSÁRIO MAGALHÃES, Andreia ANDRADE DOS SANTOS, Sandra Cristina SARMENTO DONATO DOS SANTOS E SILVA, João Manuel DE OLIVEIRA GARCIA DA FONSECA,
  • Patent number: 9914120
    Abstract: A device for use in imaging a liquid sample comprises an inlet for accepting the sample, a connection conduit and a detection chamber for detection of the sample, preferably optical detection of the sample. The connection conduit connects the inlet to the detection chamber and contains one or more dry reagents for reaction with the sample as the sample passes through the connection conduit. Specific embodiments include devices arranged for treating a blood sample, in particular lysing and staining the sample. The liquid flow may be driven by capillary effect. The device may further include liquid handling structures arranged for centrifugally driven liquid flow, for example to meter a volume of sample and separate the sample into phases by centrifugation.
    Type: Grant
    Filed: March 12, 2013
    Date of Patent: March 13, 2018
    Assignee: Biosurfit S.A.
    Inventors: João Manuel De Oliveira Garcia Da Fonseca, Ricardo Cabeça
  • Publication number: 20180017483
    Abstract: Methods for determining a sample concentration of target entities in a sample, for example, determining a concentration of target antigens or antibodies in a blood sample or other biological sample.
    Type: Application
    Filed: July 25, 2017
    Publication date: January 18, 2018
    Inventor: João Manuel de Oliveira Garcia Da Fonseca
  • Publication number: 20170307514
    Abstract: Methods for determining a sample concentration of target entities in a sample, for example, determining a concentration of target antigens or antibodies in a blood sample or other biological sample.
    Type: Application
    Filed: October 6, 2015
    Publication date: October 26, 2017
    Applicant: BIOSURFIT S.A.
    Inventor: João MANUEL DE OLIVEIRA GARCIA DA FONSECA
  • Publication number: 20170212028
    Abstract: Systems and methods for classifying blood cells in a blood sample are disclosed. A series of frames of the blood sample as it flows through a field of view of an image capture device are captured and analysed. Advantageously, the disclosed systems and methods combine the availability of morphological cell data with the convenience of a flow-through arrangement. The classification results can be used for estimating cell counts in a blood sample.
    Type: Application
    Filed: September 29, 2015
    Publication date: July 27, 2017
    Applicant: BIOSURFIT S.A.
    Inventors: Francisco CORREIA DE MATOS NOLASCO LAMAS, João MANUEL DE OLIVEIRA GARCIA DA FONSECA, André DO ROSÁRIO MAGALHÃES, José PEDRO SANTOS MANSO CÔRTE-REAL
  • Patent number: 9632022
    Abstract: The disclosure relates to processing SPR signals, in particular signals obtained by illuminating a conductive surface with light at two wavelengths. Processing SPR signals can involve processing a first and second signal indicative of an intensity of light, received from a conductive layer at which SPR has occurred, as a function of angle of incidence, reflection or diffraction at the layer. The first and second signals each have two dips corresponding to a respective wavelength of the light at a respective angle at which surface plasmon resonance occurs for the respective wavelength and a peak between the two dips. The processing includes deriving a first and second value of a quantity indicative of signal magnitudes in the region of the peak. The first and second values can be compared to detect a change in refractive index at the layer after the first signal and before the second signal was captured.
    Type: Grant
    Filed: March 5, 2013
    Date of Patent: April 25, 2017
    Assignee: Biosurfit S.A.
    Inventor: Joao Manuel De Oliveira Garcia Da Fonseca
  • Publication number: 20150109614
    Abstract: The disclosure relates to processing SPR signals, in particular signals obtained by illuminating a conductive surface with light at two wavelengths. Processing SPR signals can involve processing a first and second signal indicative of an intensity of light, received from a conductive layer at which SPR has occurred, as a function of angle of incidence, reflection or diffraction at the layer. The first and second signals each have two dips corresponding to a respective wavelength of the light at a respective angle at which surface plasmon resonance occurs for the respective wavelength and a peak between the two dips. The processing includes deriving a first and second value of a quantity indicative of signal magnitudes in the region of the peak. The first and second values can be compared to detect a change in refractive index at the layer after the first signal and before the second signal was captured.
    Type: Application
    Filed: March 5, 2013
    Publication date: April 23, 2015
    Inventor: Joao Manuel De Oliveira Garcia Da Fonseca
  • Publication number: 20150085275
    Abstract: Disclosed are methods and devices for photometric measurements of a liquid sample. The methods and devices use one or more diffractive reflective surfaces to enable a light beam incident on a measurement chamber to be steered so as to be reflected inside the measurement chamber to achieve relatively long optical paths in the measurement chamber. The liquid sample may be blood or blood serum. The measurement chamber may be provided in a microfluidic device, for example a centrifugal microfluidic device. Some embodiments enable multiplexing of different wavelengths or path lengths. Some embodiments make use of multiple returned beams to determine the position and/or orientation of the measurement chamber.
    Type: Application
    Filed: November 29, 2012
    Publication date: March 26, 2015
    Inventor: Joäo Manuel De Oliveira Garcia Da Fonseca
  • Publication number: 20150024426
    Abstract: A device for use in imaging a liquid sample comprises an inlet for accepting the sample, a connection conduit and a detection chamber for detection of the sample, preferably optical detection of the sample. The connection conduit connects the inlet to the detection chamber and contains one or more dry reagents for reaction with the sample as the sample passes through the connection conduit. Specific embodiments include devices arranged for treating a blood sample, in particular lysing and staining the sample. The liquid flow may be driven by capillary effect. The device may further include liquid handling structures arranged for centrifugally driven liquid flow, for example to meter a volume of sample and separate the sample into phases by centrifugation.
    Type: Application
    Filed: March 12, 2013
    Publication date: January 22, 2015
    Inventors: João Manuel De Oliveira Garcia Da Fonseca, Ricardo Cabeça