Patents by Inventor Jo Van Ginderachter

Jo Van Ginderachter has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HUMAN CCR8 BINDERS
    Publication number: 20240076391
    Abstract: The present invention relates to human CCR8 (hCCR8) binders, wherein the hCCR8 binder is cross-reactive with a non-human primate CCR8. Such binders are particularly useful for the depletion of intra-tumoural regulatory T-cells and immunotherapy in general.
    Type: Application
    Filed: December 23, 2021
    Publication date: March 7, 2024
    Inventors: Hui Qi Lu, Catelijne Stortelers, Nadia Van Boxel, Shanna Van Zwam, Jimmy Borloo, Bruno Dombrecht, Jo Van Ginderachter, Pascal Merchiers, Rosa Martin
  • NON-BLOCKING HUMAN CCR8 BINDERS
    Publication number: 20240052044
    Abstract: The present invention relates to human CCR8 (hCCR8) binders, wherein the hCCR8 binder is a non-blocking binder of hCCR8.
    Type: Application
    Filed: December 23, 2021
    Publication date: February 15, 2024
    Inventors: Hui Qi Lu, Catelijne Stortelers, Nadia Van Boxel, Shanna Van Zwam, Jimmy Borloo, Bruno Dombrecht, Jo Van Ginderachter, Pascal Merchiers, Rosa Martin
  • MURINE CROSS-REACTIVE HUMAN CCR8 BINDERS
    Publication number: 20240052045
    Abstract: The present invention relates to human CCR8 (hCCR8) binders, wherein the hCCR8 binder is cross-reactive with murine CCR8. Such binders are particularly useful for the depletion of intra-tumoural regulatory T-cells and immunotherapy in general.
    Type: Application
    Filed: December 23, 2021
    Publication date: February 15, 2024
    Inventors: Hui Qi Lu, Catelijne Stortelers, Nadia Van Boxel, Shanna Van Zwam, Jimmy Borloo, Bruno Dombrecht, Jo Van Ginderachter, Pascal Merchiers, Rosa Martin
  • AN LTBR AGONIST IN COMBINATION THERAPY AGAINST CANCER
    Publication number: 20240018248
    Abstract: The present invention relates to a combination comprising a Treg depletor and an LTBR agonist. Such a combination is particularly useful for use in the treatment of a cancer.
    Type: Application
    Filed: November 30, 2021
    Publication date: January 18, 2024
    Inventors: Gabriele Bergers, Elizabeth Allen, Bruno Dombrecht, Pascal Merchiers, Jo Van Ginderachter
  • Human PD-L1-binding immunoglobulins
    Patent number: 11858960
    Abstract: The invention relates to polypeptides, in particular polypeptides comprising an immunoglobulin domain, binding to human Programmed Death Ligand-1 (huPDL1) and to applications of such polypeptides such as for use as a medicament or for use as diagnostic agent, for example as an immunotracer.
    Type: Grant
    Filed: March 1, 2019
    Date of Patent: January 2, 2024
    Assignee: VRIJE UNIVERSITEIT BRUSSEL
    Inventors: Jo Van Ginderachter, Geert Raes, Nick Devoogdt, Marleen Keyaerts, Quentin Lecocq, Catarina Xavier, Karine Breckpot, Katrijn Broos, Jessica Bridoux
  • Immunoglobulin single variable domains directed against macrophage migration inhibitory factor
    Patent number: 11098113
    Abstract: The present invention relates to immunoglobulin single variable domains that bind MIF and more in particular to polypeptides that comprise or essentially consist of one or more such immunoglobulin single variable domains; to nucleic acids encoding such polypeptides; to methods for preparing such polypeptides; to compositions and in particular to pharmaceutical compositions that comprise such polypeptides, for prophylactic, therapeutic or diagnostic purposes.
    Type: Grant
    Filed: September 15, 2017
    Date of Patent: August 24, 2021
    Assignees: VIB VZW, Vrije Universiteit Brussel
    Inventors: Peter Vanlandschoot, Ines Cabrito, Benoît Stijlemans, Amanda Sparkes, Jo Van Ginderachter, Patrick De Baetselier
  • Tumor-associated dendritic cell preparations and uses thereof
    Patent number: 11083751
    Abstract: The present application relates to tumor-associated dendritic cell (TADC) preparations and their use in treatment of tumor metastasis.
    Type: Grant
    Filed: February 22, 2017
    Date of Patent: August 10, 2021
    Assignees: VIB VZW, Vrije Universiteit Brussel, Universiteit Gent
    Inventors: Jo Van Ginderachter, Damya Laoui, Jiri Keirsse, Martin Guilliams
  • HUMAN PD-L1-BINDING IMMUNOGLOBULINS
    Publication number: 20210147546
    Abstract: The invention relates to polypeptides, in particular polypeptides comprising an immunoglobulin domain, binding to human Programmed Death Ligand-1 (huPDL1) and to applications of such polypeptides such as for use as a medicament or for use as diagnostic agent, for example as an immunotracer.
    Type: Application
    Filed: March 1, 2019
    Publication date: May 20, 2021
    Applicant: Vrije Universiteit Brussel
    Inventors: Jo Van Ginderachter, Geert Raes, Nick Devoogdt, Marleen Keyaerts, Quentin Lecocq, Catarina Xavier, Karine Breckpot, Katrijn Broos, Jessica Bridoux
  • IMMUNOGLOBULIN SINGLE VARIABLE DOMAINS DIRECTED AGAINST MACROPHAGE MIGRATION INHIBITORY FACTOR
    Publication number: 20190309056
    Abstract: The present invention relates to immunoglobulin single variable domains that bind MIF and more in particular to polypeptides that comprise or essentially consist of one or more such immunoglobulin single variable domains; to nucleic acids encoding such polypeptides; to methods for preparing such polypeptides; to compositions and in particular to pharmaceutical compositions that comprise such polypeptides, for prophylactic, therapeutic or diagnostic purposes.
    Type: Application
    Filed: September 15, 2017
    Publication date: October 10, 2019
    Applicants: VIB VZW, Vrije Universiteit Brussel
    Inventors: Peter Vanlandschoot, Ines Cabrito, Benoît Stijlemans, Amanda Sparkes, Jo Van Ginderachter, Patrick De Baetselier
  • TUMOR-ASSOCIATED DENDRITIC CELL PREPARATIONS AND USES THEREOF
    Publication number: 20190054116
    Abstract: The present application relates to tumor-associated dendritic cell (TADC) preparations and their use in treatment of tumor metastasis.
    Type: Application
    Filed: February 22, 2017
    Publication date: February 21, 2019
    Inventors: Jo Van Ginderachter, Damya Laoui, Jiri Keirsse, Martin Guilliams
  • Targeting and in vivo imaging of tumor-associated macrophages
    Patent number: 9913920
    Abstract: The disclosure relates to activities and characteristics of tumor-associated macrophages (TAMs). In particular, immunoglobulin single variable domains are provided against markers of TAMs, and methods using the same for in vivo imaging of tumor cells, as well as cancer diagnostics and therapeutics.
    Type: Grant
    Filed: August 6, 2015
    Date of Patent: March 13, 2018
    Assignees: VIB VZW, Vrije Universiteit Brussel
    Inventors: Kiavash Movahedi, Damya Laoui, Steve Schoonooghe, Geert Raes, Patrick De Baetselier, Jo Van Ginderachter, Nick Devoogdt, Tony Lahoutte
  • Anti-macrophage mannose receptor single variable domains for targeting and in vivo imaging of tumor-associated macrophages
    Patent number: 9556273
    Abstract: The disclosure relates to immunoglobulin single variable domains directed against human macrophage mannose receptor (MMR) and their uses in the field of oncology. More specifically, it concerns immunoglobulin single variable domains, including single-domain antibodies (sdAbs), against human MMR and their use in targeting and in vivo imaging of tumor-associated macrophages, with applications in the field of cancer diagnostics and therapeutics and monitoring of the disease.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: January 31, 2017
    Assignees: VIB VZW, Vrije Universiteit Brussel
    Inventors: Jo Van Ginderachter, Patrick De Baetselier, Nick Devoogdt, Tony Lahoutte, Damya Laoui, Kiavash Movahedi, Geert Raes, Steve Schoonooghe
  • TARGETING AND IN VIVO IMAGING OF TUMOR-ASSOCIATED MACROPHAGES
    Publication number: 20150335770
    Abstract: The disclosure relates to activities and characteristics of tumor-associated macrophages (TAMs). In particular, immunoglobulin single variable domains are provided against markers of TAMs, and methods using the same for in vivo imaging of tumor cells, as well as cancer diagnostics and therapeutics.
    Type: Application
    Filed: August 6, 2015
    Publication date: November 26, 2015
    Inventors: Kiavash Movahedi, Damya Laoui, Steve Schoonooghe, Geert Raes, Patrick De Baetselier, Jo Van Ginderachter, Nick Devoogdt, Tony Lahoutte
  • Targeting and in vivo imaging of tumor-associated macrophages
    Patent number: 9101674
    Abstract: The invention relates to activities and characteristics of tumor-associated macrophages (TAMs). In particular, immunoglobulin single variable domains are provided against markers of TAMs, and methods using the same for in vivo imaging of tumor cells, as well as cancer diagnostics and therapeutics.
    Type: Grant
    Filed: May 24, 2012
    Date of Patent: August 11, 2015
    Assignees: VIB VZW, Vrije Universiteit Brussel
    Inventors: Kiavash Movahedi, Damya Laoui, Steve Schoonooghe, Geert Raes, Patrick De Baetselier, Jo Van Ginderachter, Nick Devoogdt, Tony Lahoutte
  • ANTI-MACROPHAGE MANNOSE RECEPTOR SINGLE VARIABLE DOMAINS FOR TARGETING AND IN VIVO IMAGING OF TUMOR-ASSOCIATED MACROPHAGES
    Publication number: 20150093336
    Abstract: The disclosure relates to immunoglobulin single variable domains directed against human macrophage mannose receptor (MMR) and their uses in the field of oncology. More specifically, it concerns immunoglobulin single variable domains, including single-domain antibodies (sdAbs), against human MMR and their use in targeting and in vivo imaging of tumor-associated macrophages, with applications in the field of cancer diagnostics and therapeutics and monitoring of the disease.
    Type: Application
    Filed: March 15, 2013
    Publication date: April 2, 2015
    Inventors: Jo Van Ginderachter, Patrick De Baetselier, Nick Devoogdt, Tony Lahoutte, Damya Laoui, Kiavash Movahedi, Geert Raes, Steve Schoonooghe
  • TARGETING AND IN VIVO IMAGING OF TUMOR-ASSOCIATED MACROPHAGES
    Publication number: 20120301394
    Abstract: The invention relates to activities and characteristics of tumor-associated macrophages (TAMs). In particular, immunoglobulin single variable domains are provided against markers of TAMs, and methods using the same for in vivo imaging of tumor cells, as well as cancer diagnostics and therapeutics.
    Type: Application
    Filed: May 24, 2012
    Publication date: November 29, 2012
    Applicant: VIB VZW
    Inventors: Kiavash Movahedi, Damya Laoui, Steve Schoonooghe, Geert Raes, Patrick De Baetselier, Jo Van Ginderachter, Nick Devoogdt, Tony Lahoutte
  • Selective targeting of intratumoral cells
    Publication number: 20110262348
    Abstract: The present invention relates to the field of tumor growth and biology. The invention relates to activities and characteristics of tumor-associated macrophages, and uses of such for the diagnosis and treatment of cancer and tumor growth.
    Type: Application
    Filed: March 29, 2011
    Publication date: October 27, 2011
    Applicants: Vrije Universiteit Brussel, VIB VZW
    Inventors: Kiavash Movahedi, Damya Laoui, Steve Schoonooghe, Geert Raes, Patrick De Baetselier, Jo Van Ginderachter, Nick Devoogdt, Tony Lahoutte