Abstract: Compounds and compositions, their use and methods using the compounds and compositions for preventing an infection, e.g. an infection by a virus or bacterium, or treating an infection, e.g. a virus or bacterial infection, or treating a disease caused by an infection, e.g. a virus or bacterial infection, and a method of increasing the binding of virus neutralizing antibodies, an in vitro method of detecting virus-specific antibodies in a sample obtained from a subject, a compound for use in a method of detecting of virus-specific antibodies in a subject, and a kit for the detection of virus-specific antibodies.

Abstract: There are methods and apparatus, including computer program products, for a flexible generation framework. The generation framework encapsulates a variety of different code generation technologies within a common interface. This allows various types of generator cores operating in various development environments to be integrated into the framework, and enables the generation of code using various generating technologies.

Abstract: There are methods and apparatus, including computer program products, for a flexible generation framework. The generation framework encapsulates a variety of different code generation technologies within a common interface. This allows various types of generator cores operating in various development environments to be integrated into the framework, and enables the generation of code using various generating technologies.

Abstract: There are methods and apparatus, including computer program products, for a flexible generation framework. The generation framework encapsulates a variety of different code generation technologies within a common interface. This allows various types of generator cores operating in various development environments to be integrated into the framework, and enables the generation of code using various generating technologies.

Abstract: Embodiments of the invention are generally directed to a system and method for a Web service definition. A development environment may receive input selecting a Web service interface. The development environment may also receive input to specify one or more system independent features of the selected interface. In an embodiment, the development environment may create a Web service definition descriptor file that includes the received input specifying the one or more system independent features.

Abstract: A development environment may receive input selecting a Web service implementation. The development environment may also receive input to define a virtual interface of the selected Web service implementation. The development environment may create a virtual interface descriptor file that includes the received input defining the virtual interface. The development environment may generate a Web service description based, at least in part, on the virtual interface descriptor file.

Abstract: A computing device may define a virtual interface to provide an interface for a Web service implementation. The computing device may also create a Web service definition to specify a behavior of the defined virtual interface. The computing device may then provide a Web service archive that includes the virtual interface and the Web service definition.

Abstract: A pluggable model framework in a model-view-controller (MVC) environment. The pluggable model framework contains elements that relate to one or more of a development tool for an application, a metamodel that defines development objects associated with the application, a generator for generating code based on the metamodel, and an application run-time. The pluggable model framework includes an extension point that corresponds to at least one of the elements. A plug-in interfaces to the pluggable model framework by way of the extension point. The plug-in corresponds to a model used by the application.

Abstract: There are methods and apparatus, including computer program products, for using incremental generation to develop an application. The incremental generation includes identifying a first main development object. Main development objects related to the first main development objects by an aggregation relationship are identified. Main development objects related to the first main development object by an association relationship are also identified. A determination is made as to whether any identified main development objects have changed. If any identified main development objects have changed, the first main development object is re-generated.

Abstract: A pluggable model framework in a model-view-controller (MVC) environment. The pluggable model framework contains elements that relate to one or more of a development tool for an application, a metamodel that defines development objects associated with the application, a generator for generating code based on the metamodel, and an application run-time. The pluggable model framework includes an extension point that corresponds to at least one of the elements. A plug-in interfaces to the pluggable model framework by way of the extension point. The plug-in corresponds to a model used by the application.

Abstract: Embodiments of the invention are generally directed to a system and method for a Web service virtual interface. A development environment may receive input selecting a Web service implementation. The development environment may also receive input to define a virtual interface of the selected Web service implementation. In an embodiment, the development environment may create a virtual interface descriptor file that includes the received input defining the virtual interface. The development environment may generate a Web service description based, at least in part, on the virtual interface descriptor file.

Abstract: Embodiments of the invention are generally directed to a system and method for a Web service definition. A development environment may receive input selecting a Web service interface. The development environment may also receive input to specify one or more system independent features of the selected interface. In an embodiment, the development environment may create a Web service definition descriptor file that includes the received input specifying the one or more system independent features.

Abstract: There are methods and apparatus, including computer program products, for a flexible generation framework. The generation framework encapsulates a variety of different code generation technologies within a common interface. This allows various types of generator cores operating in various development environments to be integrated into the framework, and enables the generation of code using various generating technologies.

Abstract: There are methods and apparatus, including computer program products, for using incremental generation to develop an application. The incremental generation includes identifying a first main development object. Main development objects related to the first main development objects by an aggregation relationship are identified. Main development objects related to the first main development object by an association relationship are also identified. A determination is made as to whether any identified main development objects have changed. If any identified main development objects have changed, the first main development object is re-generated.

Abstract: Substituted pyrido-oxazines can be prepared by reduction of the corresponding ketones. They are useful active compounds in medicaments, in particular for the treatment of hyperlipoproteinaemia, lipoproteinaemia and arteriosclerosis.

Abstract: Substituted pyrrolo-pyridines can be prepared by reduction of the corresponding ketones. They are useful active compounds for medicaments and can be employed, for example, for the treatment of hyperlipoproteinaemia, lipoproteinaemia and arteriosclerosis.

Abstract: Blood sugar levels are reduced by administration of novel 4-thienyl-dihydropyridines of the formula ##STR1## in which R.sup.1 represents 1 or 2 halogen atoms, or represents straight-chain, branched or cyclic alkyl with up to 8 carbon atoms,R.sup.2 represents a straight-chain, branched or cyclic, saturated or unsaturated hydrocarbon radical which has up to 15 carbon atoms, is optionally interrupted by one or two oxygen atoms, -N-phenyl or --SO.sub.n -- (n=0, 1 or 2) and is optionally substituted by halogen, phenyl, hydroxyl, cyano, amino, C.sub.1 -C.sub.6 -alkylamino, di-C.sub.1 -C.sub.6 -alkylamino, pyridyl, piperidino, N-phenylpiperazino, N-methylpiperazino, morpholino or N-benzyl-N-methyl-amino,R.sup.3 represents hydrogen, or represents straight-chain, branched or cyclic alkyl which has up to 6 carbon atoms and is optionally substituted by halogen, hydroxyl, amino or amino-C.sub.1 -C.sub.6 -alkoxy, or represents cyano or formyl andR.sup.

Abstract: Blood sugar levels are reduced by administration of novel 4-thienyl-dihydropyridines of the formula ##STR1## in which R.sup.1 represents 1 or 2 halogen atoms, or represents straight-chain, branched or cyclic alkyl with up to 8 carbon atoms,R.sup.2 represents a straight-chain, branched or cyclic, saturated or unsaturated hydrocarbon radical which has up to 15 carbon atoms, is optionally interrupted by one or two oxygen atoms, -N-phenyl or --SO.sub.n --(n=0, 1 or 2) and is optionally substituted by halogen, phenyl, hydroxyl, cyano, amino, C.sub.1 -C.sub.6 -alkylamino, di-C.sub.1 -C.sub.6 -alkylamino, pyridyl, piperidino, N-phenylpiperazino, N-methylpiperazino, morpholino or N-benzyl-N-benzyl-N-methyl-amino,R.sup.3 represents hydrogen, or represents straight-chain, branched or cyclic alkyl which has up to 6 carbon atoms and is optionally substituted by halogen, hydroxyl, amino or amino-C.sub.1 -C.sub.6 -alkoxy, or represents cyano or formyl andR.sup.

Abstract: Blood-sugar-lowering dihydropyridines of the formula ##STR1## in which R.sup.1 represents phenyl, naphthyl, thienyl, pyridyl, chromenyl or thiochromenyl, it being possible for the radicals mentioned each to carry up to 2 identical or different substituents from the series comprising halogen, alkyl, alkoxy and alkylthio with in each case up to 6 carbon atoms, fluoroalkyl and fluoroalkoxy with in each case up to 3 carbon atoms and 3 fluorine atoms, nitro and cyano,R.sup.2 represents straight-chain, branched or cyclic alkyl which has up to 8 carbon atoms, can be interrupted in the alkyl chain by an oxygen or a sulphur atom and can be substituted by halogen, phenyl, cyano, hydroxyl, amino, alkylamino or dialkylamino with in each case up to 3 carbon atoms per alkyl group or by N-benzylmethylamino,R.sup.

Abstract: Reducing blood sugar with the novel dihydropyridinelactols, or salts thereof, of the formula ##STR1## in which R.sup.1 represents a phenyl, naphthyl, thienyl, pyridyl, chromonyl, thiochromonyl or thiochromenyl radical, the stated radicals optionally containing 1 or 2 identical or different substituents from the group consisting of fluorine, chlorine and bromine, alkyl, alkoxy and alkylthio, each having 1 to 6 carbon atoms, and fluoroalkyl or fluoroalkoxy, each having up to 3 carbon atoms and 3 fluorine atoms, and nitro and cyano,R.sup.2 represents a straight-chain, branched or cyclic alkyl having up to 12 carbon atoms which is optionally interrupted by 1 or 2 oxygen or sulphur atoms and which is optionally substituted by fluorine, chlorine, phenyl, cyano, hydroxyl, amino, C.sub.1 -C.sub.3 -alkylamino, di-C.sub.1 -C.sub.3 -alkylamino or N-benzylmethylamino,R.sup.3 represents cyano or straight-chain or branched alkyl which has up to 4 carbon atoms and is optionally interrupted in the chain by N-C.sub.1 -C.sub.