Patents by Inventor Joachim Demnitz

Joachim Demnitz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Tetrazole derivatives and their use as potassium channel modulators
    Patent number: 9556132
    Abstract: A tetrazole derivative of general formula (I), a pharmaceutical composition comprising said compound and its use for treating, alleviating or preventing diseases or disorders relating to the activity of potassium channels.
    Type: Grant
    Filed: June 25, 2013
    Date of Patent: January 31, 2017
    Assignee: Saniona A/S
    Inventors: Joachim Demnitz, Susanne Jorgensen
  • NOVEL TETRAZOLE DERIVATIVES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS
    Publication number: 20150203458
    Abstract: A tetrazole derivative of general formula (I), a pharmaceutical composition comprising said compound and its use for treating, alleviating or preventing diseases or disorders relating to the activity of potassium channels.
    Type: Application
    Filed: June 25, 2013
    Publication date: July 23, 2015
    Applicant: SANIONA APS
    Inventors: Joachim Demnitz, Susanne Jorgensen
  • 2, 3-diamino-quinazolinone derivatives and their medical use
    Patent number: 8178544
    Abstract: This invention provides 2,3-diamino-quinazolinone compounds of Formula (I) stereoisomers thereof, pharmaceutically-acceptable addition salts thereof, and N-oxides thereof, wherein the variables are as defined in the specification. The 2,3-diamino-quinazolinone compounds have medical utility. The 2,3-diamino-quinazolinone compounds can be used for the manufacture of medicaments, including pharmaceutical compositions. This invention also provides methods of treating disorders, diseases, or conditions which are responsive to activation of Kv7 channels.
    Type: Grant
    Filed: May 22, 2008
    Date of Patent: May 15, 2012
    Assignee: Neurosearch A/S
    Inventors: Carsten Jessen, William Dalby Brown, Joachim Demnitz, Dorte Strøbæk, Mads P. G. Korsgaard, Palle Christophersen
  • ERG CHANNEL OPENERS FOR THE TREATMENT OF CARDIAC ARRHYTHMIAS
    Publication number: 20110071164
    Abstract: This invention relates to the use of ERG channel openers for the treatment of cardiac arrhythmias, and to the use of specific compounds for such treatment. In a separate aspect the invention provides novel compounds useful as ERG channel openers.
    Type: Application
    Filed: November 9, 2010
    Publication date: March 24, 2011
    Inventors: Søren Peter OLESEN, Morten Grunnet, Palle Christophersen, Dorte STRØBÆK, Joachim Demnitz, Rie S. Hansen
  • ERG channel openers for the treatment of cardiac arrhythmias
    Patent number: 7851492
    Abstract: This invention relates to the use of ERG channel openers for the treatment of cardiac arrhythmias, and to the use of specific compounds for such treatment. In a separate aspect the invention provides novel compounds useful as ERG channel openers.
    Type: Grant
    Filed: September 6, 2004
    Date of Patent: December 14, 2010
    Assignee: Neurosearch A/S
    Inventors: Søren Peter Olesen, Morten Grunnet, Palle Christophersen, Dorte Strøbæk, Joachim Demnitz, Rie S. Hansen
  • PYRROLO [3, 4-h] ISOQUINOLINE COMPOUNDS AND METHODS FOR MODULATING GATED ION CHANNELS
    Publication number: 20100197721
    Abstract: The present invention relates to compositions and methods to modulate the activity of gated ion channels.
    Type: Application
    Filed: April 12, 2010
    Publication date: August 5, 2010
    Applicant: AROS PHARMA APS
    Inventors: Rahul VOHRA, Joachim DEMNITZ, Philip K. AHRING, Zhonghong GAN, Nachhattarpal GILL
  • NOVEL 2, 3-DIAMINO-QUINAZOLINONE DERIVATIVES AND THEIR MEDICAL USE
    Publication number: 20100160315
    Abstract: This invention relates to novel 2,3-diamino-quinazolinone derivatives having medical utility, to use of the 2,3-diamino-quinazolinone derivatives of the invention for the manufacture of a medicament, to pharmaceutical compositions comprising the 2,3-diamino-quinazolinone derivatives of the invention, and to methods of treating a disorder, disease or a condition of a subject, which disorder, disease or condition is responsive to activation of Kv7 channels.
    Type: Application
    Filed: May 22, 2008
    Publication date: June 24, 2010
    Applicant: Neuro Search A/S
    Inventors: Carsten Jessen, William Dalby Brown, Joachim Demnitz, Dorte Strobaek, Mads P.G. Korsgaard, Palle Christophersen
  • NOVEL BENZAMIDINE DERIVATIVES USEFUL AS POTASSIUM CHANNEL MODULATORS
    Publication number: 20100144809
    Abstract: This invention relates to novel benzamidine derivatives of formula (I) that are found to be potent modulators of potassium channels and, as such, are valuable candidates for the treatment of diseases or disorders as diverse as those which are responsive to the modulation of potassium channels. A stereoisomer or a mixture of its stereoisomers, or an N-oxide thereof, or a pharmaceutically-acceptable addition salt thereof, wherein B may be absent (i.e. no heterocyclic ring is formed); and when absent, the nitrogen next to B holds a hydrogen (i.e. “NH”), and A represents NH2 or OH; or B may be present (i.e. forms part of a heterocyclic ring); and when present, B represents C?O or C?S; and A represents NH or O; and wherein the rest of variables are as specified in claim 1.
    Type: Application
    Filed: May 7, 2008
    Publication date: June 10, 2010
    Applicant: Neuro Search A/S
    Inventors: Antonio Nardi, Joachim Demnitz, Morten Grunnet, Palle Christophersen, David Spencer Jones, Elsebet Østergaard Nielsen, Dorte Strøbæk, Lars Siim Madsen
  • NOVEL BIPHENYL THIO-UREA DERIVATIVES USEFUL AS POTASSIUM CHANNEL MODULATORS
    Publication number: 20100144736
    Abstract: The invention relates to novel biphenyl thio-urea derivatives of Formula (I), wherein A represents hydroxy or tetrazolyl; R1 represents halo, hydroxy or phenyl, which phenyl may optionally be substituted with halo; and R2 and R3, independent of each other, represent halo, trifluoromethyl, nitro and/or phenyl, that are found to be potent modulators of ion channels and, as such, they are valuable candidates for the treatment of disease or disorders as diverse as those which are responsive to modulation of ion channels.
    Type: Application
    Filed: December 17, 2007
    Publication date: June 10, 2010
    Applicant: NeuroSearch A/S
    Inventors: Antonio Nardi, Joachim Demnitz, Morten Grunnet, Palle Christophersen, David Spencer Jones, Elsebet Østergaard Nielsen, Dorte Strøbæk, Lars Siim Madsen
  • ACETAMIDE DERIVATIVES AS POTASSIUM CHANNEL MODULATORS
    Publication number: 20100137381
    Abstract: This invention relates to novel acetamide derivatives that are found to be potent modulators of ion channels, in particular potassium channels and chloride channels, and, as such, are valuable candidates for the treatment of diseases or disorders as diverse as those which are responsive to the modulation of potassium channels.
    Type: Application
    Filed: April 29, 2008
    Publication date: June 3, 2010
    Applicant: NeuroSearch A/S
    Inventors: Antonio Nardi, Morten Grunnet, Palle Christophersen, Joachim Demnitz, David Spencer Jones, Elsebet Østergaard Nielsen, Dorte Strøbæk, Lars Siim Madsen
  • NOVEL SEMICARBAZIDE AND CARBONYLHYDRAZIDE DERIVATIVES USEFUL AS POTASSIUM CHANNEL MODULATORS
    Publication number: 20100137327
    Abstract: This invention relates to novel semicarbazide and carbonylhydrazide derivatives that are found to be potent modulators of potassium channels and, as such, they are valuable candidates for the treatment of diseases or disorders as diverse as those which are responsive to modulation of potassium channels.
    Type: Application
    Filed: January 17, 2008
    Publication date: June 3, 2010
    Applicant: NeuroSearch A/S
    Inventors: Antonio Nardi, Joachim Demnitz, Morten Grunnet, Palle Christophersen, David Spencer Jones, Elsebet Østergaard Nielsen, Dorte Strøbæk, Lars Siim Madsen
  • Pyrrolo [3,4-H] isoquinoline compounds and methods for modulating gated ion channels
    Patent number: 7718641
    Abstract: The present invention relates to compositions and methods to modulate the activity of gated ion channels.
    Type: Grant
    Filed: November 22, 2006
    Date of Patent: May 18, 2010
    Assignee: Aros Pharma ApS
    Inventors: Rahul Vohra, Joachim Demnitz, Philip K. Ahring, Zhonghong Gan, Nachhattarpal Gill
  • NOVEL 1,4- AND 1,5-DIARYLSUBSTITUTED 1,2,3-TRIAZOLES USEFUL AS POTASSIUM CHANNEL MODULATORS
    Publication number: 20100105689
    Abstract: This invention relates to novel 1,4- and 1,5-diarylsubstituted 1,2,3-triazole derivatives that are found to be potent modulators of potassium channels and, as such, they are valuable candidates for the treatment of diseases or disorders as diverse as those which are responsive to modulation of potassium channels.
    Type: Application
    Filed: January 17, 2008
    Publication date: April 29, 2010
    Inventors: Antonio Nardi, Morten Grunnet, Joachim Demnitz, Palle Christophersen, David Spencer Jones, Elsebet Østergaard Nielsen, Dorte Strøbæk, Lars Siim Madsen
  • NOVEL CINNAMIC AMIDE DERIVATIVES USEFUL AS ION CHANNEL MODULATORS
    Publication number: 20100087496
    Abstract: This invention relates to novel cinnamic amide derivatives that are found to be potent modulators of ion channels and, as such, they are valuable candidates for the treatment of diseases or disorders as diverse as those which are responsive to modulation of ion channels.
    Type: Application
    Filed: December 17, 2007
    Publication date: April 8, 2010
    Applicant: NeuroSearch A/S
    Inventors: Antonio Nardi, Morten Grunnet, Joachim Demnitz, Thomas Diness Jensen, Palle Christophersen, David Spencer Jones, Elsebet Ostergaard Nielsen, Dorte Strobaek, Lars Siim Madsen
  • NOVEL QUINAZOLINONE DERIVATIVES AND THEIR MEDICAL USE
    Publication number: 20090036473
    Abstract: This invention relates to novel quinazolinone derivatives having medical utility, to use of the quinazolinone derivatives of the invention for the manufacture of a medicament, to pharmaceutical compositions comprising the quinazolinone derivatives of the invention, and to methods of treating a disorder, disease or a condition of a subject, which disorder, disease or condition is responsive to activation of Kv7 channels.
    Type: Application
    Filed: March 9, 2007
    Publication date: February 5, 2009
    Inventors: William Dalby Brown, Carsten Jessen, Joachim Demnitz, Tino Dyhring, Dorte Strobaek
  • Potassium channel modulators
    Patent number: 7429618
    Abstract: This invention relates to novel compounds useful as potassium channel modulators. More specifically the invention provides chemical compounds useful as modulators of SKCa and/or IKCa channels.
    Type: Grant
    Filed: March 7, 2007
    Date of Patent: September 30, 2008
    Assignee: Neurosearch A/S
    Inventors: Alex Haahr Gouliaev, Frank Abildgaard Slok, Lene Teuber, Joachim Demnitz
  • Compositions and methods for modulating gated ion channels
    Publication number: 20080021034
    Abstract: The present invention relates to compositions and methods to modulate the activity of gated ion channels.
    Type: Application
    Filed: April 10, 2007
    Publication date: January 24, 2008
    Applicant: PainCeptor Pharma Corporation
    Inventors: Joachim Demnitz, Philip Ahring
  • Compositions and methods for modulating gated ion channels
    Publication number: 20080004272
    Abstract: The present invention relates to compositions and methods to modulate the activity of gated ion channels.
    Type: Application
    Filed: April 10, 2007
    Publication date: January 3, 2008
    Applicant: PainCeptor Pharma Corporation
    Inventors: Rahul Vohra, Chang-Qing Wei, Zhonghong Gan, Joachim Demnitz, Philip Ahring
  • Diphenylurea Derivatives Useful As Potassium Channel Activators
    Publication number: 20070293553
    Abstract: The present invention relates to the medical use of a certain group of diphenyl urea derivatives as potassium channel blockers for treating cardiovascular diseases, an obstructive or inflammatory airway disease, urinary incontinence, psychosis, epilepsy or pain, or for facilitating the blood-brain barrier permeability for other therapeutic substances. In other aspects the invention relates to the use of these compounds in a method of therapy.
    Type: Application
    Filed: December 14, 2005
    Publication date: December 20, 2007
    Inventors: Bjarne Dahl, Palle Christophersen, Joachim Demnitz
  • Compositions and methods for modulating gated ion channels
    Publication number: 20070191418
    Abstract: The present invention relates to compositions and methods to modulate the activity of gated ion channels.
    Type: Application
    Filed: November 22, 2006
    Publication date: August 16, 2007
    Inventors: Rahul Vohra, Joachim Demnitz, Philip Ahring, Zhonghong Gan, Nachhattarpal Gill