Abstract: A method for packaging products, wherein packaging material web is transported in direction of an upwardly open pair of folding claws, is cut to length while forming a planar blank of the wrapper, and the blank is positioned above the folding claws, wherein the product is metered, the product portion is pre-shaped, and the blank by placing thereon the pre-shaped product portion is folded into the claws while forming the upwardly open wrapper. Thereafter, the upward-projecting lateral longitudinal peripheries of the wrapper are folded inward onto the product portion, whereupon the transverse peripheries of the wrapper which extend perpendicular thereto are folded inward onto the product portion. The lateral longitudinal peripheries and transverse peripheries of the wrapper are folded inward onto the product portion and are simultaneously connected to one another, while the wrapper provided with the product portion is still situated in the pair of folding claws.

Abstract: The present invention relates to novel compounds as new chemical entities with thymine skeleton, these compounds for use as in medicine, especially in the treatment of carcinoma, HSP27-associated diseases and cystic fibrosis; and a pharmaceutical product containing at least one of these compounds. Finally, a method of production of that novel compounds is presented. General formula of these compounds is formula (I): as further defined in claim 1.

Abstract: A method for packaging products, wherein packaging material web is transported in direction of an upwardly open pair of folding claws, is cut to length while forming a planar blank of the wrapper, and the blank is positioned above the folding claws, wherein the product is metered, the product portion is pre-shaped, and the blank by placing thereon the pre-shaped product portion is folded into the claws while forming the upwardly open wrapper. Thereafter, the upward-projecting lateral longitudinal peripheries of the wrapper are folded inward onto the product portion, whereupon the transverse peripheries of the wrapper which extend perpendicular thereto are folded inward onto the product portion. The lateral longitudinal peripheries and transverse peripheries of the wrapper are folded inward onto the product portion and are simultaneously connected to one another, while the wrapper provided with product portion is still situated in the pair of folding claws.

Abstract: The present invention relates to novel compounds as new chemical entities with thymine skeleton, these compounds for use as in medicine, especially in the treatment of carcinoma, HSP27-associated diseases and cystic fibrosis; and a pharmaceutical product containing at least one of these compounds. Finally, a method of production of that novel compounds is presented. General formula of these compounds is formula (I): as further defined in claim 1.

Abstract: The present invention relates to novel HSP27 inhibitors, in particular thymine derivatives according to general formula (VI), (VII) or (VII) and phenothiazine derivatives according to formula (V), and to their use as drugs for the selective inhibition of the heat shock protein HSP27 (HSPB1), in particular for use in the treatment of carcinomas or cystic fibrosis, said inhibitors having a particularly advantageous activity in the lower micromolar or sub-micromolar active ingredient concentration range with respect to HSP27.

Abstract: The present invention relates to novel HSP27 inhibitors, in particular thymine derivatives according to general formula (VI), (VII) or (VII) and phenothiazine derivatives according to formula (V), and to their use as drugs for the selective inhibition of the heat shock protein HSP27 (HSPB1), in particular for use in the treatment of carcinomas or cystic fibrosis, said inhibitors having a particularly advantageous activity in the lower micromolar or sub-micromolar active ingredient concentration range with respect to HSP27.

Abstract: The present invention relates to novel HSP27 inhibitors, in particular purine derivatives according to general formula (I) or (II) and phenothiazine derivatives according to formula (V), and to their use as drugs for the selective inhibition of the heat shock protein HSP27 (HSPB1), in particular for use in the treatment of carcinomas or cystic fibrosis, said inhibitors having a particularly advantageous activity in the lower micromolar or sub-micromolar active ingredient concentration range with respect to HSP2.

Abstract: A magnetic safety closure for a protection device that is movable with respect to a fixed part includes a housing that is attachable to the protection device and includes a handle for opening and closing the protection device. The housing includes a sensor housing that is attachable to the fixed part and provided with a sensor for determining whether the protection device is closed or open. The housing attachable to the protection device has an initiating device for the sensor and is opposite the sensor when the protection device is closed. The housing and the sensor housing share a magnet arrangement having at least one holding magnet and an associated pole plate. The handle is a two armed lever pivotably mounted on the housing, with arm of the lever facing the sensor housing with its free end disconnecting the holding magnet from its associated pole plate when the handle is pivoted out in order to open the protection device.

Abstract: The invention relates to a magnetic safety closure for a protection device moveable with respect to a fixed part, comprising: a housing attachable to the protection device and provided with a handle for opening and closing the protection device; the housing further comprising a sensor housing attachable to the fixed part and provided with a sensor for determining whether the protection device is closed or open; the housing attachable to the protection device having an initiating device for the sensor, which device is opposite said sensor when the protection device is closed; and the housing and the sensor housing sharing between them a magnet arrangement having at least one holding magnet and an associated pole plate; wherein the handle is a two-armed lever pivotably mounted on the housing, one arm of the lever facing the sensor housing and with its free end disconnecting the at least one holding magnet of the magnet arrangement from its associated pole plate when the handle is pivoted out in order to open th

Abstract: The invention relates to a magnetic safety closure for a protection device moveable with respect to a fixed part, comprising: a housing attachable to the protection device and provided with a handle for opening and closing the protection device; the housing further comprising a sensor housing attachable to the fixed part and provided with a sensor for determining whether the protection device is closed or open; the housing attachable to the protection device having an initiating device for the sensor, which device is opposite said sensor when the protection device is closed; and the housing and the sensor housing sharing between them a magnet arrangement having at least one holding magnet and an associated pole plate; wherein the handle is a two-armed lever pivotably mounted on the housing, one arm of the lever facing the sensor housing and with its free end disconnecting the at least one holding magnet of the magnet arrangement from its associated pole plate when the handle is pivoted out in order to open th

Abstract: The invention relates to a process for alignment of sheet material (1) which is processed in a machine which processes sheet material (1). To do this the sheet material (1) is aligned into one conveyor plane (9) laterally and with respect to its twisting (6) with reference to its conveyor direction (22). The position of the sheet material (1) in the conveyor plane (9) is always acquired at a point (35) on one side edge (24) of the sheet material with a position which is defined to the reference edge (23) of the sheet material (1).

Abstract: A radio frequency compatible multi-board cluster (300) having three shielded housings (301, 301, 303) for containing three component parts of a radio, namely, the controller, the transmitter, and the receiver. These shielded housings (301, 301, 303) are electrically and physically intercoupled with one another at 90.degree. angles to form a bracket-receiving cavity (401) there between.

Abstract: An apparatus for indicating the position of at least two rotatable mechanical elements in an indication field of a rotary switch, includes a pair of rotatable elements; an indication panel; a transparent dial skirt connected to each rotatable, each skirt having representative symbols arranged in an area along the outer periphery thereof for indicating the position of the rotatable elements and the areas of the skirt with the symbols overlapping in the indication panel.