Abstract: The present invention relates to determining a treatment response index. In order to improve and facilitate hypertension treatment procedures, a device (10) for determining a treatment response index is provided that comprises a data input (12), a data processor (14) and a data output (16). The data input is configured to receive a value (18) of at least one first measurement of a physiological parameter of a subject's vasculature under a first condition; and to provide a value (20) of at least one second measurement of the physiological parameter of the vasculature under a second condition. In the second condition, a pre-determined stimulation is provided, and the first condition is non-stimulated or at least differently stimulated. The data processor is configured to generate a treatment response index. In an example, the data output is configured to provide a classification of the subject into one of at least two groups of subjects, based on the treatment response index.

Abstract: The present invention relates to determining a treatment response index. In order to improve and facilitate hypertension treatment procedures, a device (10) for determining a treatment response index is provided that comprises a data input (12), a data processor (14) and a data output (16). The data input is configured to receive a value (18) of at least one first measurement of a physiological parameter of a subjects vasculature under a first condition; and to provide a value (20) of at least one second measurement of the physiological parameter of the vasculature under a second condition. In the second condition, a pre-determined stimulation is provided, and the first condition is non-stimulated or at least differently stimulated. The data processor is configured to generate a treatment response index. In an example, the data output is configured to provide a classification of the subject into one of at least two groups of subjects, based on the treatment response index.

Abstract: The present disclosure pertains to a system and method for monitoring and for facilitating pulmonary and systemic hemodynamics in the treatment and/or prevention of cardiac arrhythmias or structural cardiac changes, caused by altered preload. The system comprises: a pressure generator; a first sensor configured to generate output signals conveying information related to venous blood accumulation during cardiac preload in the subject; a second sensor configured to generate output signals conveying information related to systemic arterial circulation in the subject; and one or more hardware processors configured by machine-readable instructions to control the pressure generator to adjust the pressure levels of the flow of breathable gas during one or both of inhalation and exhalation to facilitate the pulmonary and systemic circulation based on the output signals from the first sensor and the second sensor.

Abstract: Method and related system for marker-based navigation. A first image is capturing (S530) with a medical imaging apparatus (ENDO), whilst a light source (LS1) of an implanted marker device (MD) is in a low intensity state and a second light source (LS2) of the medical imaging apparatus (IA) is in a high intensity state, higher than the low intensity state of the marker. A second image is captured (S560) with the medical imaging apparatus (ENDO), whilst the light source (LS1) of the implanted marker device is in a high intensity state and the second light source (LS2) of the medical imaging apparatus (IA) is in a low intensity state, lower than the high intensity state of the marker. The two images may then be combined to obtain a combined image that represents the location of the marker at high signal-to-noise-ratio.

Abstract: Presented are concepts for monitoring cardio-respiratory function of a patient. One such concept employs an optical sensor unit (10) for sensing light from tissue of the patient in response to temporary airway pressure changes provided via a respiratory support unit (50). By sensing variations in blood volume in the central site vein in response to temporary airway pressure changes, venous information of the person may be obtained.

Abstract: A device is provided for controlling the nitric oxide levels within the lungs of a subject. The device comprises a detector for detecting the respiration cycle of the subject and a stimulator for applying an acoustic or vibratory stimulus to the subject. The stimulator is controlled in dependence on the detected respiration cycle. In particular, acoustic stimulation may be provided at the onset of inspiration. In this way, the nitric oxide flow can be controlled in a way to ensure that the paranasal nitric oxide is nearly fully inspired. This provides a higher nitric oxide concentration in the lung/alveoli.

Abstract: Presented are concepts for monitoring cardio-respiratory function of a patient. One such concept comprises detecting light or sound from the sublingual vasculature using a sublingual sensor unit adapted to be positioned at a sublingual vasculature of the patient's tongue and to generate a sensor output signal based on the detected light or sound. A processing unit adapted to receive at least one of the sensor unit output signal, wherein the sensor unit and the processing unit are arranged to analyze the venous component in the sensor output signal. An output signal from the sublingual sensor may then be used to provide information on cardio-respiratory parameters like respiration rate and respiration rate variability, for example.

Abstract: The present invention relates to determining a treatment response index. In order to improve and facilitate hypertension treatment procedures, a device (10) for determining a treatment response index is provided that comprises a data input (12), a data processor (14) and a data output (16). The data input is configured to receive a value (18) of at least one first measurement of a physiological parameter of a subjects vasculature under a first condition; and to provide a value (20) of at least one second measurement of the physiological parameter of the vasculature under a second condition. In the second condition, a pre-determined stimulation is provided, and the first condition is non-stimulated or at least differently stimulated. The data processor is configured to generate a treatment response index. In an example, the data output is configured to provide a classification of the subject into one of at least two groups of subjects, based on the treatment response index.

Abstract: The present invention discloses an endovascular device arrangement (1) comprising a vascular access port (10); an endovascular device (20) for inserting into a patient's blood vessel through said vascular access port; and a near-field communication module (15) including an antenna (17), wherein at least the antenna of the near-field communication module is located within the vascular access port; and the endovascular device comprises an electronic device (25) and an antenna arrangement (21) communicatively coupled to said electronic device for maintaining a near-field communication link between the electronic device and the near-field communication module whilst the endovascular device passes through the vascular access port, said antenna arrangement comprising an array of antenna elements (21) located along a shaft of the endovascular device (20), each of said antenna elements being communicatively coupled to said electronic device (25).

Abstract: An apparatus for applying energy to an object includes an arrangement of energy emitting elements for outputting energy to the object. At least some of the energy emitting elements are configured to emit energy to the object independently from each other.

Abstract: A tongue manipulation device (10) has a tissue anchor (20) for attachment to the tongue, a bone anchor (22) typically for attachment to the mandible and a tether line (24) which fixes the tissue anchor to the bone anchor. The bone anchor comprises a tether line spool arrangement which comprises a spool (46) rotatable about a spooling axis and a spooling locking arrangement (54). The spooling locking arrangement is controlled by rotation about the spooling axis between spooling locking and permitting configurations. In this way, the physician implanting and setting the device can perform titration and subsequent locking as two independent operations.

Abstract: A system (100) includes an imaging system (102) and a pressure delivery system (104). The imaging system includes a data acquisition system (114 and 116) and is configured to produce data. The pressure delivery system is configured to produce a periodic airflow variation. The system further includes an operator console (120) configured to control the imaging system to scan a subject receiving the periodic airflow variation and map the periodic airflow variation and first data. The system further includes a reconstructor (516) configured to reconstruct the first data and generate first volumetric image data indicative of the periodic airflow variation.

Abstract: A cardiopulmonary resuscitation, CPR, device (100, 200, 400) for delivering intrathoracic pressure pulses to a subject (290), the device comprising an air pressure generator (110, 310, 410) for delivering air to the airways of the subject (290), wherein the air pressure generator (110, 310, 410) is configured to: operate a first mode, wherein in the first mode the air pressure generator (110, 310, 410) generates a first output (412, 770a, 770b) comprising a first plurality of positive pressure pulses (771) for temporally increasing the subject's intrathoracic pressure to induce compressions of the heart of the subject (290) by increasing the volume of the subject's lungs; operate a second mode, wherein in the second mode the air pressure generator (110, 310, 410) generates a second output (414, 880) comprising a second plurality of positive pressure pulses for providing an assured airflow to the lungs of the subject (290); and deliver a resulting output (425, 986, 1086) to the airways of the subject (290), th

Abstract: A tongue advancer assembly for a tongue manipulation system includes a core mount and a tongue advancer for coupling to the core mount. The core mount includes a connection rod coupling for coupling the tongue advancer assembly to a distal end of a connection rod.

Abstract: Presented are concepts for monitoring cardio-respiratory function of a patient. One such concept employs an optical sensor unit (10) for sensing light from tissue of the patient in response to temporary airway pressure changes provided via a respiratory support unit (50). By sensing variations in blood volume in the central site vein in response to temporary airway pressure changes, venous information of the person may be obtained.

Abstract: The present disclosure pertains to a system and method for monitoring and for facilitating pulmonary and systemic hemodynamics in the treatment and/or prevention of cardiac arrhythmias or structural cardiac changes, caused by altered preload. The system comprises: a pressure generator; a first sensor configured to generate output signals conveying information related to venous blood accumulation during cardiac preload in the subject; a second sensor configured to generate output signals conveying information related to systemic arterial circulation in the subject; and one or more hardware processors configured by machine-readable instructions to control the pressure generator to adjust the pressure levels of the flow of breathable gas during one or both of inhalation and exhalation to facilitate the pulmonary and systemic circulation based on the output signals from the first sensor and the second sensor.

Abstract: A measurement circuit for measuring a property in a body comprises: a resonant circuit comprising a first element and a second element, where in at least one of the first element and the second element is configured such that a property thereof is dependent on the property in the body; and a non-linear element arranged to generate intermodulation products when the circuit is driven by an input signal comprising a first component at a first frequency and a second component at a second frequency. A measurement system for measuring a property in a body comprises: a measurement circuit as described above; a driving circuit for providing a driving signal to the measurement circuit, wherein the driving signal comprises a first component at a first frequency and a second component at a second frequency; and an analyzer circuit for analyzing a response of the measurement circuit in order to obtain a measurement of the property.

Abstract: Presented are concepts for monitoring cardio-respiratory function of a patient. One such concept comprises detecting light or sound from the sublingual vasculature using a sublingual sensor unit adapted to be positioned at a sublingual vasculature of the patient's tongue and to generate a sensor output signal based on the detected light or sound. A processing unit adapted to receive at least one of the sensor unit output signal, wherein the sensor unit and the processing unit are arranged to analyze the venous component in the sensor output signal. An output signal from the sublingual sensor may then be used to provide information on cardio-respiratory parameters like respiration rate and respiration rate variability, for example.

Abstract: An apparatus and method for determining a calibration parameter for a blood pressure measurement device. According to an aspect, there is provided an apparatus for determining a calibration parameter for a first blood pressure, BP, measurement device, the apparatus comprising a control unit that is to be coupled to a first BP measurement device that is for obtaining physiological characteristic measurements of a physiological characteristic of a subject and for determining a blood pressure measurement of the subject from the physiological characteristic measurements, a second BP measurement device that is for obtaining measurements of the blood pressure of the subject and a ventilator that is for providing a controlled flow of gas to the subject.

Abstract: A system for analysis of the upper airway has at least two sensors are provided along a flow path leading to the mouth and/or nose of a user. A relation is derived between the two sensor signals, and this is interpreted to detect at least the presence of upper airway obstructions, and preferably also the location and/or extent of such obstructions.