Abstract: The invention relates to a method for manufacturing a surface-alloyed cylindrical, partly cylindrical or hollow cylindrical structural member where in the zone of incidence of the energy beam there is formed a locally bounded melting bath with a heating and melting front, a solution zone and a solidification front. At the side of the energy beam the hard material powder is deposited via a conveyor device in the direction of gravity and is supplied co-ordinated with the feed movement of the workpiece in a width which corresponds to the width of the linear focus and a layer height of 0.3-3 mm is thereby produced. The hard-material powder supplied to the workpiece surface in the heating front of the melting bath is heated by an energy beam at a wavelength of 780-940 nm and in contact with the liquefied matrix alloy the powder is immediately dissolved in the melting bath.

Abstract: A method of casting has a mold assembled on a base plate. The finished mold is rotated by approximately 180° around a horizontal rotational axis. A casting container with an upwardly positioned aperture end, removed from the mold, is filled with melt for one casting operation. The casting container is sealingly coupled by the aperture end to the ingate end of the mold. The mold, together with its contacting casting container, is rotated by approximately 180° around a horizontal axis. Accordingly, the melt reaches the mold, and the casting container is removed from the coupled position away from the mold.

Abstract: The invention relates to a method for manufacturing a surface-alloyed cylindrical, partly cylindrical or hollow cylindrical structural member where in the zone of incidence of the energy beam there is formed a locally bounded melting bath with a heating and melting front, a solution zone and a solidification front. At the side of the energy beam the hard material powder is deposited via a conveyor device in the direction of gravity and is supplied co-ordinated with the feed movement of the workpiece in a width which corresponds to the width of the linear focus and a layer height of 0.3-3 mm is thereby produced. The hard-material powder supplied to the workpiece surface in the heating front of the melting bath is heated by an energy beam at a wavelength of 780-940 nm and in contact with the liquefied matrix alloy the powder is immediately dissolved in the melting bath.

Abstract: A method of casting has a mold assembled on a base plate. The finished mold is rotated by approximately 180° around a horizontal rotational axis. A casting container with an upwardly positioned aperture end, removed from the mold, is filled with melt for one casting operation. The casting container is sealingly coupled by the aperture end to the ingate end of the mold. The mold, together with its contacting casting container, is rotated by approximately 180° around a horizontal axis. Accordingly, the melt reaches the mold, and the casting container is removed from the coupled position away from the mold.

Abstract: The present invention concerns a method for treating fibrotic conditions by administration of an effective amount of an antifibrotic agent. The antifibrotic agent is preferably a proline analog, such as cis-4-hydroxy-L-proline (cHyp). The antifibrotic agent is operatively linked to a monomer or a polymer, with or without a linking compound, e.g., lysine. Intravenous administration is preferred. The present method facilitates the delivery and release of the antifibrotic agent to inhibit collagen accumulation and thereby to treat fibrosis where collagen metabolism is implicated. A reduced quantity of the antifibrotic agent and a corresponding reduction in the potential for toxicity resulting from prolonged administration thereof may be realized.

Abstract: The present invention concerns a method for treating fibrotic conditions by administration of an effective amount of an antifibrotic agent. The antifibrotic agent is preferably a proline analog, such as cis-4-hydroxy-L-proline (cHyp). The antifibrotic agent is operatively linked to a monomer or a polymer, with or without a linking compound, e.g., lysine. Intravenous administration is preferred. The present method facilitates the delivery and release of the antifibrotic agent to inhibit collagen accumulation and thereby to treat fibrosis where collegen metabolism is implicated. A reduced quantity of the antifibrotic agent and a corresponding reduction in the potential for toxicity resulting from prolonged administration thereof may be realized.

Abstract: The invention relates to a process and devices for casting components in metal alloys on the tilt casting principle in which a quantity of melt metered for casting is spread over a large gate cross section without turbulence from a melt container of the mould (30) into the mould (31) by rotating the casting device. To prevent the formation of oxide and weak structural points, the melt is taken from a metering furnace under a protective gas in a melt container connected to the mould and taken thence into the mould also under a protective gas. The melt hardens there under increased gas pressure on the feeder region of the casting, whereby its properties such as fine-grained, dense structure, high stability under load and accurately dimensioned surfaces are considerably improved.

Abstract: The present invention concerns a method for treating fibrotic conditions by administration of an effective amount of an antifibrotic agent. The antifibrotic agent is preferably a proline analog, such as cis-4-hydroxy-L-proline (cHyp). The antifibrotic agent is operatively linked to a monomer or a polymer, with or without a linking compound, e.g., lysine. Intravenous administration is preferred. The present method facilitates the delivery and release of the antifibrotic agent to inhibit collagen accumulation and thereby to treat fibrosis where collegen metabolism is implicated. A reduced quantity of the antifibrotic agent and a corresponding reduction in the potential for toxicity resulting from prolonged administration thereof may be realized.