Patents by Inventor Joachim Koch
Joachim Koch has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240424099Abstract: Provided herein are methods for treating a patient suffering from cancer with an natural killer (NK) cell with a KIR-B haplotype and expresses a CD16 molecule, and a bispecific antibody which binds CD16 and CD30, along with methods of producing NK cell populations, and pharmaceutical compositions comprising the NK cells and bispecific antibodies.Type: ApplicationFiled: November 3, 2022Publication date: December 26, 2024Inventors: Peter FLYNN, Jason B. LITTEN, Thomas James FARRELL, Heather Karen RAYMON, Srinivas Sai SOMANCHI, Lisa GUERRETTAZ, Thorsten GRAEF, Joachim KOCH, Jens PAHL, Bokyung MIN, Hyojin KIM, Sanghyun LEE
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Publication number: 20240417475Abstract: The present invention relates to a bispecific antibody construct comprising (a) a first binding domain (A), which is capable of specifically binding to a first target (A) that is CD16A on the surface of an immune effector cell, wherein the first binding domain comprises: (i) a VL region comprising CDR-L1 as depicted in SEQ ID NO: 4, a CDR-L2 as depicted in SEQ ID NO: 5, and a CDR-L3 as depicted in SEQ ID NO: 6; and (ii) a VH region as depicted in SEQ ID NO: 7; and (b) a second binding domain (B), which is capable of specifically binding to a second target (B?) that is an antigen on the surface of a target cell, wherein the second target (B?) is FOLR1. The present invention also relates to related nucleic acid molecules, vectors, host cells, methods of producing the antibody constructs, pharmaceutical compositions, medical uses, and kits.Type: ApplicationFiled: November 3, 2022Publication date: December 19, 2024Inventors: Joachim KOCH, Jens PAHL, Thorsten ROSS, Jana-Julia SIEGLER, Holger DULAT
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Publication number: 20240376208Abstract: The present invention relates to an antibody construct comprising (i.) at least four first binding domains (A), wherein said first binding domain (A) is capable of specifically binding to a first target (A?) that is an immune-regulatory antigen on the surface of an innate immune effector cell, wherein the immune effector cell is a natural killer cell or a macrophage; and (ii.) a second binding domain (B), which is capable of specifically binding to a second target (B?) that is an antigen on the surface of a target cell. The present invention also relates to related nucleic acid molecules, vectors, host cells, methods of producing the antibody constructs, pharmaceutical compositions, medical uses, and kits.Type: ApplicationFiled: August 1, 2022Publication date: November 14, 2024Inventors: Uwe REUSCH, Joachim KOCH
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Publication number: 20240294647Abstract: The invention relates to multispecific antigen-binding proteins for engaging natural killer (NK) cells for triggering NK cell cytotoxicity by engaging the CD16A (Fc?RIIIA) expressed on NK cells, wherein the antigen-binding protein comprises at least two CD16A antigen-binding moieties and at least a further target antigen-binding moiety. The CD16A antigen-binding moiety comprises light chain and heavy chain variable regions linked one after another in a polypeptide chain and the variable region at the N-terminus of the polypeptide chain comprising the CD16A antigen-binding moiety is a light chain variable region.Type: ApplicationFiled: April 17, 2024Publication date: September 5, 2024Applicant: Affimed GmbHInventors: Michael Tesar, Kristina Ellwanger, Ivica Fucek, Uwe Reusch, Thorsten Ross, Joachim Koch, Erich Rajkovic, Martin Treder
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Publication number: 20230365709Abstract: The present invention relates to a trispecific antibody construct comprising (i.) a first binding domain (A), which is capable of specifically binding to a first target (A?) that is CD16A on the surface of an immune effector cell; (ii.) a second binding domain (B), which is capable of specifically binding to a second target (B?) that is another antigen on the surface of an immune effector cell, wherein said antigen is selected from the group comprising CD56, NKG2A, NKG2D, NKp30, NKp44, NKp46, NKp80, DNAM-1, SLAMF7, OX40, CD47/SIRP?, CD89, CD96, CD137, CD160, TIGIT, nectin-4, PD-1, PD-L1, LAG-3, CTLA-4, TIM-3, KIR2DL1-5, KIR3DL1-3, KIR2DS1-5 and CD3; and (iii.) a third binding domain (C), which is capable of specifically binding to a third target (C?) that is an antigen on the surface of a target cell. The present invention also relates to related nucleic acid molecules, vectors, host cells, methods of producing the antibody constructs, pharmaceutical compositions, medical uses, and kits.Type: ApplicationFiled: October 8, 2021Publication date: November 16, 2023Inventors: Thorsten ROSS, Joachim KOCH, Michael TESAR, Holger DULAT, Christian BREUNIG, Eike PETERS, Kristina ELLWANGER, Ivica FUCEK, Uwe REUSCH, Jens PAHL
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Patent number: 11535672Abstract: The invention relates to an anti-CD16A antigen binding protein for use in NK cell-based immunotherapy, wherein the anti-CD16A antigen binding protein is to be administered intermittently and in combination with a cytokine. In certain embodiments the antigen binding protein is a tetravalent and bispecific CD30/CD16A tandem diabody.Type: GrantFiled: July 24, 2019Date of Patent: December 27, 2022Assignee: AFFIMED GMBHInventors: Joachim Koch, Martin Treder, Jens Pahl, Uwe Reusch, Thorsten Ross, Erich Rajkovic, Adelheid Cerwenka
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Patent number: 11118537Abstract: The invention relates to a fuel injector (1), comprising: a pre-chamber (17) within the injector, a high-pressure injector part (3) for discharging combustible gas, which high-pressure injector part has a nozzle unit (5) and a reciprocating nozzle valve element (7), a nozzle-side end section of which is accommodated in a high-pressure chamber (11) of the high-pressure injector part (3), a pre-chamber assembly (39), within the framework of which the high-pressure chamber (11) of the high-pressure injector part (3) is separated over a nozzle-side end section, the high-pressure chamber being surrounded by the pre-chamber (17).Type: GrantFiled: June 6, 2018Date of Patent: September 14, 2021Assignee: Woodward L'Orange GmbHInventors: Ingmar Joachim Berger, Enrico Barow, Hans-Joachim Koch, Michael Nitsche
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Publication number: 20210253698Abstract: The invention relates to multispecific antigen-binding proteins for engaging natural killer (NK) cells for triggering NK cell cytotoxicity by engaging the CD16A (Fc?RIIIA)expressed on NK cells, wherein the antigen-binding protein comprises at least two CD16A antigen-binding moieties and at least a further target antigen-binding moiety. The CD16A antigen-binding moiety comprises light chain and heavy chain variable regions linked one after another in a polypeptide chain and the variable region at the N-terminus of the polypeptide chain comprising the CD16A antigen-binding moiety is a light chain variable region.Type: ApplicationFiled: April 20, 2021Publication date: August 19, 2021Applicant: Affimed GmbHInventors: Michael Tesar, Kristina Ellwanger, Ivica Fucek, Uwe Reusch, Thorsten Ross, Joachim Koch, Erich Rajkovic, Martin Treder
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Publication number: 20210169936Abstract: The application describes isolated human NK cells in a cryopreserved state, preloaded prior to freezing with an antibody construct, the antibody construct comprising at least a first binding domain binding to an NK cell receptor antigen on the cell surface of an immunological effector cell and a second binding domain binding to a cell surface antigen on the cell surface of a target cell, a method for preparation of cryopreserved preloaded human NK cells and pharmaceutical compositions comprising human NK cells which have been reconstituted from human NK cells in a cryopreserved state.Type: ApplicationFiled: February 16, 2021Publication date: June 10, 2021Inventors: Uwe REUSCH, Joachim KOCH, Martin TREDER, Holger J. DULAT
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Patent number: 11001633Abstract: The invention relates to multispecific antigen-binding proteins for engaging natural killer (NK) cells for triggering NK cell cytotoxicity by engaging the CD16A (Fc?RIIIA) expressed on NK cells, wherein the antigen-binding protein comprises at least two CD16A antigen-binding moieties and at least a further target antigen-binding moiety. The CD16A antigen-binding moiety comprises light chain and heavy chain variable regions linked one after another in a polypeptide chain and the variable region at the N-terminus of the polypeptide chain comprising the CD16A antigen-binding moiety is a light chain variable region.Type: GrantFiled: December 13, 2019Date of Patent: May 11, 2021Assignee: Affimed GmbHInventors: Michael Tesar, Kristina Ellwanger, Ivica Fucek, Uwe Reusch, Thorsten Ross, Joachim Koch, Erich Rajkovic, Martin Treder
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Publication number: 20210079874Abstract: The invention relates to a fuel injector (1), comprising: a pre-chamber (17) within the injector, a high-pressure injector part (3) for discharging combustible gas, which high-pressure injector part has a nozzle unit (5) and a reciprocating nozzle valve element (7), a nozzle-side end section of which is accommodated in a high-pressure chamber (11) of the high-pressure injector part (3), a pre-chamber assembly (39), within the framework of which the high-pressure chamber (11) of the high-pressure injector part (3) is separated over a nozzle-side end section, the high-pressure chamber being surrounded by the pre-chamber (17).Type: ApplicationFiled: June 6, 2018Publication date: March 18, 2021Applicant: Woodward L'Orange GmbHInventors: Ingmar Joachim Berger, Enrico Barow, Hans-Joachim Koch, Michael Nitsche
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Publication number: 20200109202Abstract: The invention relates to multispecific antigen-binding proteins for engaging natural killer (NK) cells for triggering NK cell cytotoxicity by engaging the CD16A (Fc?RIIIA)expressed on NK cells, wherein the antigen-binding protein comprises at least two CD16A antigen-binding moieties and at least a further target antigen-binding moiety. The CD16A antigen-binding moiety comprises light chain and heavy chain variable regions linked one after another in a polypeptide chain and the variable region at the N-terminus of the polypeptide chain comprising the CD16A antigen-binding moiety is a light chain variable region.Type: ApplicationFiled: December 13, 2019Publication date: April 9, 2020Applicant: Affimed GmbHInventors: Michael Tesar, Kristina Ellwanger, Ivica Fucek, Uwe Reusch, Thorsten Ross, Joachim Koch, Erich Rajkovic, Martin Treder
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Publication number: 20200010547Abstract: The invention relates to an anti-CD16A antigen binding protein for use in NK cell-based immunotherapy, wherein the anti-CD16A antigen binding protein is to be administered intermittently and in combination with a cytokine. In certain embodiments the antigen binding protein is a tetravalent and bispecific CD30/CD16A tandem diabody.Type: ApplicationFiled: July 24, 2019Publication date: January 9, 2020Inventors: Joachim Koch, Martin Treder, Jens Pahl, Uwe Reusch, Thorsten Ross, Erich Rajkovic, Adelheid Cerwenka
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Patent number: 10495008Abstract: The invention relates to a combustion gas injector assembly (1) comprising a combustion gas injector (3) having groups (11a,b,c) of combustion gas nozzle openings distributed around the periphery, each group having at least one combustion gas nozzle opening (13), a combustion gas nozzle valve member (9a,b,c) of the combustion gas injector (3), which member can be controlled in the open position and closed position, is associated with each group (11a,b,c) of combustion gas nozzle openings, in order to selectively discharge the combustion gas via the at least one combustion gas nozzle opening (13). The combustion gas injector assembly (1) is configured to control the combustion gas nozzle valve members (9a,b,c) successively with a predetermined time offset (T) into the closed position.Type: GrantFiled: January 19, 2017Date of Patent: December 3, 2019Assignee: L'Orange GMBHInventors: Ingmar Berger, Hans-Joachim Koch, Michael Nitsche, Steffen Siebert
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Publication number: 20190010878Abstract: The invention relates to a combustion gas injector assembly (1) comprising a combustion gas injector (3) having groups (11a,b,c) of combustion gas nozzle openings distributed around the periphery, each group having at least one combustion gas nozzle opening (13), a combustion gas nozzle valve member (9a,b,c) of the combustion gas injector (3), which member can be controlled in the open position and closed position, is associated with each group (11a,b,c) of combustion gas nozzle openings, in order to selectively discharge the combustion gas via the at least one combustion gas nozzle opening (13). The combustion gas injector assembly (1) is configured to control the combustion gas nozzle valve members (9a,b,c) successively with a predetermined time offset (T) into the closed position.Type: ApplicationFiled: January 19, 2017Publication date: January 10, 2019Applicant: L'Orange GMBHInventors: Ingmar Berger, Hans-Joachim Koch, Michael Nitsche, Steffen Siebert
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Publication number: 20140117781Abstract: A control apparatus for controlling the power of an electrical load, in particular of an electrical domestic appliance or an assembly of an electrical domestic appliance, comprises at least one sensor for detecting a parameter of an electrical supply voltage, and a processing means for comparing a parameter which is detected by the sensor with a prespecified value, and for influencing the power of the load on the basis of the result of the comparison.Type: ApplicationFiled: March 27, 2012Publication date: May 1, 2014Applicant: BSH BOSCH UND SIEMENSInventors: Janis Kesten-Kühne, Hans-Joachim Koch
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Publication number: 20130160480Abstract: An ice maker includes a frame, a mold shell having at least one chamber and capable of holding water for formation of ice cubes, and a support device which secures the mold shell in the frame and moves the mold shell between a first position for filling with water and a second position for ejecting ice cubes. The support member is able to rotate the mold shell about a rotation axis from the first position for filling with water into the second position for ejecting ice cubes. A securing device is disposed on the support device and constructed to allow manual removal of the mold shell from the ice maker and manual insertion of the mold shell into the ice maker. The securing device has at least one securing rail for pulling out and pushing in the mold shell, and extends parallel to the rotation axis.Type: ApplicationFiled: August 24, 2011Publication date: June 27, 2013Applicant: BSH BOSCH UND SIEMENS HAUSGERATE GMBHInventors: Athanasios Athanasiou, Hans-Joachim Koch
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Patent number: 6387314Abstract: A process for increasing the flame resistance of polyethylene-containing, single- or multilayer hollowware, in particular plastic fuel tanks, by heat treating the hollowware at 60-135° C.Type: GrantFiled: December 8, 1999Date of Patent: May 14, 2002Assignee: Basell Polyolefin GmbHInventors: Wolfgang Rohde, Günther Pfirrmann, Peter Bauer, Andreas Haufe, Joachim Koch
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Patent number: 6328230Abstract: A fuel injector for an internal combustion engine includes a first injection valve having a first valve element that can be displaced in an axial direction and a first actuating device located axially downstream from the first injection valve to actuate the first injection valve. The fuel injector also has at least one second injection valve with a valve element that can be axially displaced and a second actuating device to actuate the second injection valve. The second actuating device is mounted axially downstream from the first actuating device in the valve housing, and the second actuating device to actuate the second injection valve is coupled to the latter by an actuating element, in the form of a cage-like arrangement, mounted in the valve housing in such a way that it can be displaced axially and bypasses the first actuating device.Type: GrantFiled: June 15, 2000Date of Patent: December 11, 2001Assignee: L'Orange GmbHInventors: Rolf Prillwitz, Hans-Joachim Koch
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Patent number: 5958570Abstract: A laminated composite body, in particular a conveyor belt, consists of a carcass (2, 2', 2") that determines the mechanical stability of the laminated composite body, and at least one cover (1, 1') made of rubber, thermoplastic elastomer (TPE) and/or plastics that are highly resistant to mechanical damages such as notches, cuts, or the like. In order to improve the resistance of the laminated composite body, the cover (1) is made of at least two layers (10, 11, 12) with different properties that are interconnected so as to form a clear phase limit.Type: GrantFiled: December 26, 1996Date of Patent: September 28, 1999Assignee: Contitech Transportbandsysteme GmbHInventors: Dana Schwambach, Hans Uwe Bender, Hans Joachim Koch