Abstract: The present invention relates to a trispecific antibody construct comprising (i.) a first binding domain (A), which is capable of specifically binding to a first target (A?) that is CD16A on the surface of an immune effector cell; (ii.) a second binding domain (B), which is capable of specifically binding to a second target (B?) that is another antigen on the surface of an immune effector cell, wherein said antigen is selected from the group comprising CD56, NKG2A, NKG2D, NKp30, NKp44, NKp46, NKp80, DNAM-1, SLAMF7, OX40, CD47/SIRP?, CD89, CD96, CD137, CD160, TIGIT, nectin-4, PD-1, PD-L1, LAG-3, CTLA-4, TIM-3, KIR2DL1-5, KIR3DL1-3, KIR2DS1-5 and CD3; and (iii.) a third binding domain (C), which is capable of specifically binding to a third target (C?) that is an antigen on the surface of a target cell. The present invention also relates to related nucleic acid molecules, vectors, host cells, methods of producing the antibody constructs, pharmaceutical compositions, medical uses, and kits.

Abstract: The invention relates to an anti-CD16A antigen binding protein for use in NK cell-based immunotherapy, wherein the anti-CD16A antigen binding protein is to be administered intermittently and in combination with a cytokine. In certain embodiments the antigen binding protein is a tetravalent and bispecific CD30/CD16A tandem diabody.

Abstract: The invention relates to a fuel injector (1), comprising: a pre-chamber (17) within the injector, a high-pressure injector part (3) for discharging combustible gas, which high-pressure injector part has a nozzle unit (5) and a reciprocating nozzle valve element (7), a nozzle-side end section of which is accommodated in a high-pressure chamber (11) of the high-pressure injector part (3), a pre-chamber assembly (39), within the framework of which the high-pressure chamber (11) of the high-pressure injector part (3) is separated over a nozzle-side end section, the high-pressure chamber being surrounded by the pre-chamber (17).

Abstract: The invention relates to multispecific antigen-binding proteins for engaging natural killer (NK) cells for triggering NK cell cytotoxicity by engaging the CD16A (Fc?RIIIA)expressed on NK cells, wherein the antigen-binding protein comprises at least two CD16A antigen-binding moieties and at least a further target antigen-binding moiety. The CD16A antigen-binding moiety comprises light chain and heavy chain variable regions linked one after another in a polypeptide chain and the variable region at the N-terminus of the polypeptide chain comprising the CD16A antigen-binding moiety is a light chain variable region.

Abstract: The application describes isolated human NK cells in a cryopreserved state, preloaded prior to freezing with an antibody construct, the antibody construct comprising at least a first binding domain binding to an NK cell receptor antigen on the cell surface of an immunological effector cell and a second binding domain binding to a cell surface antigen on the cell surface of a target cell, a method for preparation of cryopreserved preloaded human NK cells and pharmaceutical compositions comprising human NK cells which have been reconstituted from human NK cells in a cryopreserved state.

Abstract: The invention relates to multispecific antigen-binding proteins for engaging natural killer (NK) cells for triggering NK cell cytotoxicity by engaging the CD16A (Fc?RIIIA) expressed on NK cells, wherein the antigen-binding protein comprises at least two CD16A antigen-binding moieties and at least a further target antigen-binding moiety. The CD16A antigen-binding moiety comprises light chain and heavy chain variable regions linked one after another in a polypeptide chain and the variable region at the N-terminus of the polypeptide chain comprising the CD16A antigen-binding moiety is a light chain variable region.

Abstract: The invention relates to a fuel injector (1), comprising: a pre-chamber (17) within the injector, a high-pressure injector part (3) for discharging combustible gas, which high-pressure injector part has a nozzle unit (5) and a reciprocating nozzle valve element (7), a nozzle-side end section of which is accommodated in a high-pressure chamber (11) of the high-pressure injector part (3), a pre-chamber assembly (39), within the framework of which the high-pressure chamber (11) of the high-pressure injector part (3) is separated over a nozzle-side end section, the high-pressure chamber being surrounded by the pre-chamber (17).

Abstract: The invention relates to multispecific antigen-binding proteins for engaging natural killer (NK) cells for triggering NK cell cytotoxicity by engaging the CD16A (Fc?RIIIA)expressed on NK cells, wherein the antigen-binding protein comprises at least two CD16A antigen-binding moieties and at least a further target antigen-binding moiety. The CD16A antigen-binding moiety comprises light chain and heavy chain variable regions linked one after another in a polypeptide chain and the variable region at the N-terminus of the polypeptide chain comprising the CD16A antigen-binding moiety is a light chain variable region.

Abstract: The invention relates to an anti-CD16A antigen binding protein for use in NK cell-based immunotherapy, wherein the anti-CD16A antigen binding protein is to be administered intermittently and in combination with a cytokine. In certain embodiments the antigen binding protein is a tetravalent and bispecific CD30/CD16A tandem diabody.

Abstract: The invention relates to a combustion gas injector assembly (1) comprising a combustion gas injector (3) having groups (11a,b,c) of combustion gas nozzle openings distributed around the periphery, each group having at least one combustion gas nozzle opening (13), a combustion gas nozzle valve member (9a,b,c) of the combustion gas injector (3), which member can be controlled in the open position and closed position, is associated with each group (11a,b,c) of combustion gas nozzle openings, in order to selectively discharge the combustion gas via the at least one combustion gas nozzle opening (13). The combustion gas injector assembly (1) is configured to control the combustion gas nozzle valve members (9a,b,c) successively with a predetermined time offset (T) into the closed position.

Abstract: The invention relates to a combustion gas injector assembly (1) comprising a combustion gas injector (3) having groups (11a,b,c) of combustion gas nozzle openings distributed around the periphery, each group having at least one combustion gas nozzle opening (13), a combustion gas nozzle valve member (9a,b,c) of the combustion gas injector (3), which member can be controlled in the open position and closed position, is associated with each group (11a,b,c) of combustion gas nozzle openings, in order to selectively discharge the combustion gas via the at least one combustion gas nozzle opening (13). The combustion gas injector assembly (1) is configured to control the combustion gas nozzle valve members (9a,b,c) successively with a predetermined time offset (T) into the closed position.

Abstract: A control apparatus for controlling the power of an electrical load, in particular of an electrical domestic appliance or an assembly of an electrical domestic appliance, comprises at least one sensor for detecting a parameter of an electrical supply voltage, and a processing means for comparing a parameter which is detected by the sensor with a prespecified value, and for influencing the power of the load on the basis of the result of the comparison.

Abstract: An ice maker includes a frame, a mold shell having at least one chamber and capable of holding water for formation of ice cubes, and a support device which secures the mold shell in the frame and moves the mold shell between a first position for filling with water and a second position for ejecting ice cubes. The support member is able to rotate the mold shell about a rotation axis from the first position for filling with water into the second position for ejecting ice cubes. A securing device is disposed on the support device and constructed to allow manual removal of the mold shell from the ice maker and manual insertion of the mold shell into the ice maker. The securing device has at least one securing rail for pulling out and pushing in the mold shell, and extends parallel to the rotation axis.

Abstract: A process for increasing the flame resistance of polyethylene-containing, single- or multilayer hollowware, in particular plastic fuel tanks, by heat treating the hollowware at 60-135° C.

Abstract: A fuel injector for an internal combustion engine includes a first injection valve having a first valve element that can be displaced in an axial direction and a first actuating device located axially downstream from the first injection valve to actuate the first injection valve. The fuel injector also has at least one second injection valve with a valve element that can be axially displaced and a second actuating device to actuate the second injection valve. The second actuating device is mounted axially downstream from the first actuating device in the valve housing, and the second actuating device to actuate the second injection valve is coupled to the latter by an actuating element, in the form of a cage-like arrangement, mounted in the valve housing in such a way that it can be displaced axially and bypasses the first actuating device.

Abstract: A laminated composite body, in particular a conveyor belt, consists of a carcass (2, 2', 2") that determines the mechanical stability of the laminated composite body, and at least one cover (1, 1') made of rubber, thermoplastic elastomer (TPE) and/or plastics that are highly resistant to mechanical damages such as notches, cuts, or the like. In order to improve the resistance of the laminated composite body, the cover (1) is made of at least two layers (10, 11, 12) with different properties that are interconnected so as to form a clear phase limit.

Abstract: A conveyor belt of a continuous strip-casting device for casting strips of metal, particularly steel, which belt is guided by a driven drum and a drum horizontally adjacent to the driven drum and displaceable for tensioning the belt. The belt rests in this connection on a support arranged between the drums and the side thereof facing away from the cast strip is cooled. The conveyor belt has, on the side remote from the cast strip, uniformly distributed blind holes. The blind holes are separated by webs of a minimum width. The total surface area of the webs is 0.15 to 0.4 times the total surface area of the belt. The bottoms of the blind holes have a wall thickness which, upon heating by the cast strip with simultaneous cooling of the inside surface of the blind holes, permits a bulging of the bottom of less than 1 mm.

Abstract: An incubator for premature and newborn infants includes a housing defining a first housing portion and a second housing portion. A transparent hood is mounted on the housing so as to define an enclosure with the first housing portion for accommodating the infant therein. Conditioning equipment for conditioning the air in the enclosure is mounted in the second housing portion. An exchangeable support is removably mounted in the first housing portion and is adapted for supporting the infant thereon. The second housing portion is partitioned from the air in the enclosure by means of an insert to permit those components which communicate with the air in the enclosure to be thermally disinfected. The support and the insert are configured as removable individual components resistant to temperatures of a thermal disinfection.

Abstract: The present invention relates to thermosetting two-component coating compositions containing(A) a prepolymer having an average molecular weight of from 1,000 to 15,000 having an average of from 2 to 4 ketoxime-blocked aromatic isocyanate groups;(B) a crosslinking agent corresponding to the following general formula: ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 independently represent hydrogen or C.sub.1 - to C.sub.3 -alkyl groups with the proviso that if R.sup.1 to R.sup.4 all are hydrogen, 75% of the diamine have the cis,cis-structure and optionally(C) pigments, fillers blowing agents or other known additives. The equivalent ratio of blocked isocyanate groups to NH.sub.2 groups is from about 1.35:1 to about 0.95:1, and the coating composition contains not more than about 15% by weight of organic solvents and is free from aqueous polymer dispersions or solutions.

Abstract: This invention relates to coating compositions based on aqueous polyurethane dispersions and to the use of these coating compositions for the production of top coats or finishes on PVC. The coating compositions according to the invention contain a mixture of two aqueous polyurethane dispersions which have particular chemico-physical properties.