Patents by Inventor Joachim Kohn
Joachim Kohn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8551511Abstract: A variety of phase-separated biocompatible polymer compositions are described. In preferred embodiments the polymers are bioresorbable and/or biodegradable, and have desirable mechanical properties, such as fracture and/or fatigue toughness, that have previously not been a primary design criteria for such polymers. The polymer compositions are useful in a variety of medical applications, such as in the fabrication of medical devices.Type: GrantFiled: October 11, 2009Date of Patent: October 8, 2013Assignee: Rutgers, The State University of New JerseyInventors: Don K. Brandom, Durgadas Bolikal, Lioubov Kabalnova, James E. McGrath, Joachim Kohn
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Patent number: 8476399Abstract: The present invention relates to new classes of monomeric compounds, which may be polymerized to form novel biodegradable and bioresorble polymers and co-polymers. These polymers and co-polymers, while not limited thereto, may be adapted for radio-opacity and are useful for medical device applications and controlled release therapeutic formulations.Type: GrantFiled: July 18, 2012Date of Patent: July 2, 2013Assignee: Rutgers, The State University of New JerseyInventors: Durgadas Bolikal, Don K. Brandom, Lioubov Kabalnova, Ernest G. Baluca, Joachim Kohn
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Patent number: 8414871Abstract: Topical compositions are provided in which active compounds for topical delivery through the stratum corneum are complexed with nanospheres of a triblock copolymer having an A-B-A structure wherein each A end block is a water-soluble, hydrophilic and non-toxic polymer or oligomer; and the hydrophobic middle B block is a hydrophobic polymer or oligomer with the same or different repeating units having the structure according to formula:(I) wherein X is —C—R—C— or —C—; Z is between 2 and about 100, inclusive; R1 is CH?CH or (CH2), wherein n is from 0 to 18, inclusive; R2 is selected from hydrogen and straight and branched alkyl, alkoxy, alkylaryl and alkoxyaryl groups containing up to 18 carbon atoms; and R is selected from a bond or straight and branched alkyl, alkoxy, alkylaryl and alkoxyaryl groups containing up to 18 carbon atoms.Type: GrantFiled: January 31, 2008Date of Patent: April 9, 2013Assignee: Rutgers, The State University of New JerseyInventors: Joachim Kohn, Bozena Michniak, David Devore, Larisa Sheihet, Prafulla Chandra, Priya Batheja
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Publication number: 20130085238Abstract: The present invention relates to new classes of monomeric compounds, which may be polymerized to form novel biodegradable and bioresorble polymers and co-polymers. These polymers and co-polymers, while not limited thereto, may be adapted for radio-opacity and are useful for medical device applications and controlled release therapeutic formulations.Type: ApplicationFiled: July 18, 2012Publication date: April 4, 2013Applicant: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEYInventors: Durgadas Bolikal, Don K. Brandom, Lioubov Kabalnova, Ernest G. Baluca, Joachim Kohn
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Patent number: 8252887Abstract: The present invention relates to new classes of monomeric compounds, which may be polymerized to form novel biodegradable and bioresorbable polymers and co-polymers. These polymers and co-polymers, while not limited thereto, may be adapted for radioopacity and are useful for medical device applications and controlled release therapeutic formulations.Type: GrantFiled: October 11, 2009Date of Patent: August 28, 2012Assignee: Rutgers, The State University of New JerseyInventors: Durgadas Bolikal, Don K. Brandom, Lioubov Kabalnova, Ernest G. Baluca, Joachim Kohn
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Patent number: 8114951Abstract: The present invention is directed to polyarylates comprising repeating units having the structure: as well as their preparation and use as cell growth substrates.Type: GrantFiled: July 31, 2009Date of Patent: February 14, 2012Assignee: Rutgers, The State University of New JerseyInventors: Ken James, Stephen Brochini, Varawut Tangpasuthadol, Joachim Kohn
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Patent number: 7991523Abstract: Disclosed is a method of indirect tire pressure monitoring. The method includes: learning test variables (DIAG, SIDE, AXLE), which describe the rotational movements of the wheels; determining rolling circumference differences (?DIAG, ?SIDE, ?AXLE) from actually determined test variables and the learnt test variables; learning at least one torsion natural frequency fp for at least one tire from the oscillation behavior of the individual tires; determining at least one shift of the torsion natural frequency ?fp from at least one actually determined torsion natural frequency and from the at least one learnt torsion natural frequency; and combining the rolling circumference differences (?DIAG, ?SIDE, ?AXLE) with the at least one shift of the torsion natural frequency fp in a joint warning strategy for detecting and warning of tire inflation pressure loss.Type: GrantFiled: February 2, 2005Date of Patent: August 2, 2011Assignee: Continental Teves AG & Co. oHGInventors: Martin Grieβer, Andreas Köbe, Frank Edling, Vladimir Koukes, Jörg Cunz, Lennert Gootjes, Joachim Kohn, Ines Runge, Maik Hofmann
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Publication number: 20110086001Abstract: Phase-separated elastomeric biocompatible polymer compositions are disclosed that are bioresorbable and/or biodegradable, and are useful in a variety of medical applications in which a low modulus polymer is desired, such as in the fabrication of medical devices.Type: ApplicationFiled: October 12, 2010Publication date: April 14, 2011Applicant: Rutgers UniversityInventors: Don K. Brandom, Durgadas Bolikal, Lioubov Kabalnova, Joachim Kohn
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Publication number: 20100234555Abstract: The present invention relates to new classes of monomeric compounds, which may be polymerized to form novel biodegradable and bioresorble polymers and co-polymers. These polymers and co-polymers, while not limited thereto, may be adapted for radioopacity and are useful for medical device applications and controlled release therapeutic formulations.Type: ApplicationFiled: October 11, 2009Publication date: September 16, 2010Applicant: Rutgers, the State UniversityInventors: Durgadas Bolikal, Don K. Brandom, Lioubov Kabalnova, Ernest G. Baluca, Joachim Kohn
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Publication number: 20100228343Abstract: A variety of phase-separated biocompatible polymer compositions are described. In preferred embodiments the polymers are bioresorbable and/or biodegradable, and have desirable mechanical properties, such as fracture and/or fatigue toughness, that have previously not been a primary design criteria for such polymers. The polymer compositions are useful in a variety of medical applications, such as in the fabrication of medical devices.Type: ApplicationFiled: October 11, 2009Publication date: September 9, 2010Applicant: Rutgers, the State UniversityInventors: Don K. BRANDOM, Durgadas Bolikal, Lioubov Kabalnova, James E. McGrath, Joachim Kohn
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Publication number: 20100166854Abstract: A method of forming electrospun fiber mats from a plurality of different biodegradable polymeric fibers is provided, in which a plurality of up to six different biodegradable polymer solutions are electrospun together by a method comprising the steps of providing a plurality of up to six different biodegradable polymer solutions each containing at least one biologically or pharmaceutically active material and each in communication with a needle for electrospinning a biodegradable polymer fiber from the solution, and pumping each solution through its respective needle into an electric field under conditions effective to produce uncontrolled charged jet streams of the polymer solutions directed at a grounded rotating mandrel, thereby forming fiber threads of the biologically or pharmaceutically active compounds and polymers in the solutions that are deposited on the mandrel to form an electrospun non-woven fiber mat, wherein the needles are positioned for co-deposition of the fiber threads from the polymer soluType: ApplicationFiled: October 25, 2007Publication date: July 1, 2010Applicant: Rutgers, The State University of New JerseyInventors: Bozena B. Michniak-Kohn, Rashmi A. Thakur, Charles A. Florek, Joachim Kohn
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Publication number: 20080140276Abstract: Disclosed is a method of indirect tire pressure monitoring. The method includes: learning test variables (DIAG, SIDE, AXLE), which describe the rotational movements of the wheels; determining rolling circumference differences (?DIAG, ?SIDE, ?AXLE) from actually determined test variables and the learnt test variables; learning at least one torsion natural frequency fp for at least one tire from the oscillation behavior of the individual tires; determining at least one shift of the torsion natural frequency ?fp from at least one actually determined torsion natural frequency and from the at least one learnt torsion natural frequency; and combining the rolling circumference differences (?DIAG, ?SIDE, ?AXLE) with the at least one shift of the torsion natural frequency fp in a joint warning strategy for detecting and warning of tire inflation pressure loss.Type: ApplicationFiled: February 2, 2005Publication date: June 12, 2008Applicant: CONTINENTAL AGInventors: Martin Griesser, Andreas Kobe, Frank Edling, Vladimir Koukes, Lennert Gootjes, Joachim Kohn, Ines Runge, Maik Hofmann, Jorg Cunz
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Publication number: 20080131480Abstract: Biocompatible polyarylates of diphenol compounds and poly(alkylene oxide) dicarboxylic acids, articles formed therefrom and therapeutic uses are disclosed.Type: ApplicationFiled: February 19, 2008Publication date: June 5, 2008Applicant: Rutgers, The State University of New JerseyInventors: Joachim Kohn, Satish Pulapura, Arthur Schwartz, Raman Bahulekar
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Publication number: 20080107709Abstract: Iodinated and/or brominated derivatives of aromatic dihydroxy monomers are prepared and polymerized to form radio-opaque polymers. The monomers may also be copolymerized with other dihydroxy monomers. The iodinated and brominated aromatic dihydroxy monomers can be employed as radio-opacifying, biocompatible non-toxic additives for other polymeric biomaterials. Radio-opaque medical implants and drug delivery devices for implantation prepared from the polymers of the present invention are also disclosed.Type: ApplicationFiled: November 1, 2007Publication date: May 8, 2008Inventors: Joachim Kohn, Durgadas Bolikal, Sanyog Pendharkar
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Patent number: 7203612Abstract: Disclosed are different processes for the determination of the internal pressure, particularly of the minimum pressure of the tire of a motor vehicle during driving operation, through an analysis of the characteristic vibration behavior of the wheel, whereby the standardized amplitude is determined from the vibration spectrum determined and the resonance frequency is observed.Type: GrantFiled: July 8, 2004Date of Patent: April 10, 2007Assignee: Continental Teves AG & Co., OHGInventors: Andreas Köbe, Holger Behrends, Lennert Gootjes, Joachim Kohn, Ines Runge, Stefan Kluge, Alfred Duchow
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Publication number: 20060276984Abstract: Disclosed are different processes for the determination of the internal pressure, particularly of the minimum pressure of the tire of a motor vehicle during driving operation, through an analysis of the characteristic vibration behavior of the wheel, whereby the standardized amplitude is determined from the vibration spectrum determined and the resonance frequency is observed.Type: ApplicationFiled: July 8, 2004Publication date: December 7, 2006Inventors: Andreas Kobe, Holger Behrends, Lennert Gootjes, Joachim Kohn, Ines Runge, Stefan Kluge, Alfred Duchow
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Publication number: 20060204440Abstract: Iodinated and/or brominated derivatives of aromatic dihydroxy monomers are prepared and polymerized to form radio-opaque polymers. The monomers may also be copolymerized with other dihydroxy monomers. The iodinated and brominated aromatic dihydroxy monomers can be employed as radio-opacifying, biocompatible non-toxic additives for other polymeric biomaterials. Radio-opaque medical implants and drug delivery devices for implantation prepared from the polymers of the present invention are also disclosed.Type: ApplicationFiled: May 5, 2006Publication date: September 14, 2006Applicant: Rutgers, The State UniversityInventors: Joachim Kohn, Durgadas Bolikal, Sanyog Pendharkar
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Publication number: 20060182752Abstract: Biocompatible non-toxic polyarylate triblock copolymers having an A-B-A structure wherein each A is a water-soluble, hydrophilic polymer end block and the B middle block is an polyarylate oligomer. The polymers spontaneously self-assemble to form low CAC nanospheres having utility as transfection agents for gene delivery.Type: ApplicationFiled: May 15, 2003Publication date: August 17, 2006Applicant: Rutgers, The State UniversityInventors: Joachim Kohn, Corinne Vebert-Nardin, Durgadas Bolikal, Agnieszka Seyda
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Publication number: 20060034769Abstract: Preferred embodiments of the present invention relate to polymeric medical devices, such as stents. More particularly, the polymeric compositions disclosed herein comprise halogen-containing, tyrosine-derived diphenols, optionally in conjunction with other groups, such as dicarboxylic acids and/or poly(alkylene oxide), such that the medical devices made from these polymeric compositions are bioresorbable and inherently radiopaque, and exhibit physicomechanical properties consistent with the intended uses of such devices.Type: ApplicationFiled: September 27, 2004Publication date: February 16, 2006Applicant: Rutgers, The State UniversityInventors: Joachim Kohn, Durgadas Bolikal, Aaron Pesnell, Joan Zeltinger, Donald Brandom, Eric Schmid
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Publication number: 20060013882Abstract: Biocompatible non-toxic triblock copolymers having an A-B-A structure wherein each A is a hydrophilic, biocompatible end block and the B middle block is a hydrophobic desaminotyrosyl tyrosine polycarbonate or polyarylate. The copolymers spontaneously self-assemble to form low critical aggregation concentration nanospheres having utility as delivery vehicles for hydrophobic biologically or pharmaceutically active compounds.Type: ApplicationFiled: July 27, 2005Publication date: January 19, 2006Applicant: Rutgers, The State UniversityInventors: Joachim Kohn, David Devore, Larisa Sheihet, Robert Dubin