Patents by Inventor Joachim Kopka
Joachim Kopka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8420406Abstract: Described is a method for analyzing the metabolites of a biological sample which comprises quantitatively determining one or more metabolites in said sample in a way that said quantitative determination resolves isotopic mass differences within one metabolite, said method being characterized in that the sample comprises or is derived from a cell which has been maintained under conditions allowing the uptake of an isotopically labeled metabolizable compound so that the metabolites in said cell are saturated with the isotope with which said metabolizable compound is labeled. This method may further comprise, prior to quantitative determining the metabolites, combining the biological sample (i.e. the first biological sample) with a second biological sample in which the metabolites are not isotopically labeled or are isotopically labeled differently from the first biological sample; and determining in said biological samples the relative quantity of metabolites which differ by their isotopical label.Type: GrantFiled: December 17, 2004Date of Patent: April 16, 2013Assignee: Max-Planck-Gessellschaft zur Forderung der Wissenschaften E.V.Inventors: Alexander Lüdemann, Alexander Erban, Cornelia Wagner, Joachim Kopka
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Patent number: 8349186Abstract: The present invention relates to a process for extracting constituents from organic material, comprising the step of extracting with a monophasic mixture of 50% by volume to 90% by volume of methanol and 50 to 10% by volume of water and optionally 0% by volume to 40% by volume of a further solvent or solvent mixture.Type: GrantFiled: July 18, 2011Date of Patent: January 8, 2013Assignee: Metanomics GmbHInventors: Michael Manfred Herold, Martin Dostler, Ralf Looser, Tilmann B. Walk, Achim Fegert, Martin Kluttig, Britta Lehmann, Silke Heidemann, Annette Hennig, Joachim Kopka
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Publication number: 20110272353Abstract: The present invention relates to a process for extracting constituents from organic material, comprising the step of extracting with a monophasic mixture of 50% by volume to 90% by volume of methanol and 50 to 10% by volume of water and optionally 0% by volume to 40% by volume of a further solvent or solvent mixture.Type: ApplicationFiled: July 18, 2011Publication date: November 10, 2011Applicant: Metanomics GmbH and Co. KGaAInventors: Michael Manfred Herold, Martin Dostler, Ralf Looser, Tilmann B. Walk, Achim Fegert, Martin Kluttig, Britta Lehmann, Silke Heidemann, Annette Hennig, Joachim Kopka
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Patent number: 7981294Abstract: The present invention relates to a process for extracting constituents from organic material, comprising the step of extracting with a monophasic mixture of 50% by volume to 90% by volume of methanol and 50 to 10% by volume of water and optionally 0% by volume to 40% by volume of a further solvent or solvent mixture.Type: GrantFiled: October 1, 2008Date of Patent: July 19, 2011Assignee: Metanomics GmbH and Co. KGaAInventors: Michael Manfred Herold, Martin Dostler, Ralf Looser, Tilmann B. Walk, Achim Fegert, Martin Kluttig, Britta Lehmann, Silke Heidemann, Annette Hennig, Joachim Kopka
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Patent number: 7606667Abstract: The invention relates to a method and device for analyzing a sample containing a number of substances. The method comprises the following steps: recording one or more mass spectra (mass spectra data D) of the sample (P); deconvoluting the mass spectra in a first evaluating device (A), which assigns the chromatographic peaks (a) and their associated deconvoluted mass spectra of one substance at a time based on the correspondence with a reference spectrum of the substance, and/or determining the intensity of the obtained peaks of the ions of the mass spectra in an evaluating device (B), which assigns the chromatographic peaks (b) of the ions and their associated mass spectra based on the correspondence of selective ions and their retention time ranges of the peaks (b) with the reference values of the substance predetermined for a substance, and verifying the assignments in a validating device (V).Type: GrantFiled: February 1, 2006Date of Patent: October 20, 2009Assignee: Metanomics GmbHInventors: Michael Manfred Herold, Martin Kluttig, Nicole Christiansen, Joachim Kopka, Jörn Quedenau
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Publication number: 20090032462Abstract: The present invention relates to a process for extracting constituents from organic material, comprising the step of extracting with a monophasic mixture of 50% by volume to 90% by volume of methanol and 50 to 10% by volume of water and optionally 0% by volume to 40% by volume of a further solvent or solvent mixture.Type: ApplicationFiled: October 1, 2008Publication date: February 5, 2009Applicant: Metanomics GmbH and Co. KGaAInventors: Michael Manfred Herold, Martin Dostler, Ralf Looser, Tilmann B. Walk, Achim Fegert, Martin Kluttig, Britta Lehmann, Silke Heidemann, Annette Hennig, Joachim Kopka
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Publication number: 20080288174Abstract: Described is a method for determining the function of a gene. This method involves determining the amount of transcript for each of a set of candidate genes in samples taken from different phenotypic and/or genotypic states of an organism and determining the amount of each of a plurality of metabolites in different samples taken from the same states as those mentioned above. Subsequently, the data obtained is analyzed by suitable mathematical methods in order to identify a transcript and metabolites which correlate in the different states, thereby identifying a transcript corresponding to a gene which influences the amount of metabolites in the organism. Furthermore described is a method for identifying a gene which is capable of modifying the amount of a metabolite in an organism and to a method for identifying a metabolite which is capable of modifying the amount of a transcript in an organism. Likewise, uses of the genes and metabolites identified in the aforementioned methods are described.Type: ApplicationFiled: March 4, 2004Publication date: November 20, 2008Inventors: Lothar Willmitzer, Alisdair Fernie, Joachim Selbig, Ewa Urbanczyk-Wochniak, Joachim Kopka, Alexander Ludemann, Ute Roessner-Tunali
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Patent number: 7431841Abstract: The invention relates to a method for the extraction of components made from organic material, comprising the step of extraction with a single-phase mixture of 50 to 90 vol. % methanol and 50 to 10 vol. % water and optionally 0 to 40 vol. % of a further solvent or solvent mixture.Type: GrantFiled: November 11, 2002Date of Patent: October 7, 2008Assignee: Metanomics GmbH & Co. KGaAInventors: Michael Manfred Herold, Martin Dostler, Ralf Looser, Tilmann B. Walk, Achim Fegert, Martin Kluttig, Britta Lehmann, Silke Heidemann, Annette Hennig, Joachim Kopka
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Publication number: 20080128607Abstract: The invention relates to a method and device for analyzing a sample containing a number of substances. The method comprises the following steps: recording one or more mass spectra (mass spectra data D) of the sample (P); deconvoluting the mass spectra in a first evaluating device (A), which assigns the chromatographic peaks (a) and their associated deconvoluted mass spectra of one substance at a time based on the correspondence with a reference spectrum of the substance, and/or determining the intensity of the obtained peaks of the ions of the mass spectra in an evaluating device (B), which assigns the chromatographic peaks (b) of the ions and their associated mass spectra based on the correspondence of selective ions and their retention time ranges of the peaks (b) with the reference values of the substance predetermined for a substance, and verifying the assignments in a validating device (V).Type: ApplicationFiled: February 1, 2006Publication date: June 5, 2008Applicant: Metanomics GmbHInventors: Michael Manfred Herold, Martin Kluttig, Nicole Christiansen, Joachim Kopka, Jorn Quedenau
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Patent number: 7311838Abstract: The present invention relates to a process for isolating constituents from organic material, comprising the following process steps: a) freeze-drying of the organic material; b) extracting the constituents with a polar solvent or solvent mixture (A) and an organic solvent or solvent mixture (B), it being possible for the extracts of the extraction with (A) and (B) to form one phase; c) combining the extracts (A) and (B) to give one phase; and d) carrying out an esterification/transesterification in the unpolar phase with an alcohol, the esterification/transesterification being carried out in the presence of a volatile acid; the process being a high-throughput process.Type: GrantFiled: November 11, 2002Date of Patent: December 25, 2007Assignee: Metanomics GmbH & Co. KGaAInventors: Michael Manfred Herold, Martin Dostler, Ralf Looser, Tilmann B. Walk, Achim Fegert, Martin Kluttig, Britta Lehmann, Silke Heidemann, Annette Hennig, Joachim Kopka
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Publication number: 20070141712Abstract: Described is a method for analysing the metabolites of a biological sample which comprises quantitatively determining one or more metabolites in said sample in a way that said quantitative determination resolves isotopic mass differences within one metabolite, said method being characterized in that the sample comprises or is derived from a cell which has been maintained under conditions allowing the uptake of an isotopically labeled metabolizable compound so that the metabolites in said cell are saturated with the isotope with which said metabolizable compound is labeled. This method may further comprise, prior to quantitative determining the metabolites, combining the biological sample (i.e. the first biological sample) with a second biological sample in which the metabolites are not isotopically labeled or are isotopically labeled differently from the first biological sample; and determining in said biological samples the relative quantity of metabolites which differ by their isotopical label.Type: ApplicationFiled: December 17, 2004Publication date: June 21, 2007Applicant: Max-Planck-Gessellschaft Zur Forderung Der Wissenschaften E.V.Inventors: Alexander Ludemann, Alexander Erban, Cornelia Wagner, Joachim Kopka
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Publication number: 20040262221Abstract: The present invention relates to a process for isolating constituents from organic material, comprising the following process steps:Type: ApplicationFiled: May 5, 2004Publication date: December 30, 2004Inventors: Michael Manfred Herold, Martin Dostler, Ralf Looser, Tilmann B. Walk, Achim Fegert, Martin Kluttig, Britta Lehmann, Silke Heidemann, Annette Hennig, Joachim Kopka
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Publication number: 20040260105Abstract: The invention relates to a method for the extraction of components made from organic material, comprising the step of extraction with a single-phase mixture of 50 to 90 vol. % methanol and 50 to 10 vol. % water and optionally 0 to 40 vol. % of a further solvent or solvent mixture.Type: ApplicationFiled: May 5, 2004Publication date: December 23, 2004Inventors: Michael Manfred Herold, Martin Dostler, Ralf Looser, Tilmann B. Walk, Achim Fegert, Martin Kluttig, Britta Lehmann, Silke Heidemann, Annette Hennig, Joachim Kopka
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Patent number: RE43838Abstract: The present invention relates to a process for isolating constituents from organic material, comprising the following process steps: a) freeze-drying of the organic material; b) extracting the constituents with a polar solvent or solvent mixture (A) and an organic solvent or solvent mixture (B), it being possible for the extracts of the extraction with (A) and (B) to form one phase; c) combining the extracts (A) and (B) to give one phase; and d) carrying out an esterification/transesterification in the unpolar phase with an alcohol, the esterification/transesterification being carried out in the presence of a volatile acid; the process being a high-throughput process.Type: GrantFiled: January 10, 2011Date of Patent: December 4, 2012Assignee: Metanomics GmbHInventors: Michael M. Herold, Martin Dostler, Ralf Looser, Tilmann B. Walk, Achim Fegert, Martin Kluttig, Britta Lehmann, Silke Klein, Annette Hennig, Joachim Kopka