Patents by Inventor Joachim Kuhnke

Joachim Kuhnke has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 18-Methyl-19-norandrost-4-ene 17, 17-spiro ether (18-methyl-19-nor-20-spirox-4-en-3-one), and pharmaceutical products comprising the same
    Patent number: 7846917
    Abstract: The present invention describes the novel 18-methyl-19-norandrost-4-ene 17,17-spiro ethers of the general formula I in which Z is an oxygen atom, two hydrogen atoms, a group ?NOR or ?NNHSO2R, where R is a hydrogen atom or a straight- or branched-chain alkyl group having 1 to 4 or 3 to 4 carbon atoms, R4 is a hydrogen atom, a halogen atom or a trifluoromethyl group, and R6 and/or R7 may have ? or ? configuration, and R6 and R7 are independently of one another a hydrogen atom or a straight- or branched-chain alkyl group having 1 to 4 or 3 to 4 carbon atoms or a straight- or branched-chain alkenyl group having 2 to 4 or 3 to 4 carbon atoms or a saturated cycloalkyl group having 3 to 5 carbon atoms or together are a methylene group or a double bond. The novel compounds have progestational and antimineralocorticoid activity.
    Type: Grant
    Filed: June 28, 2007
    Date of Patent: December 7, 2010
    Assignee: Bayer Schering Pharma AG
    Inventors: Rolf Bohlmann, Joachim Kuhnke, Jan Huebner, Norbert Gallus, Frederik Menges, Steffen Borden, Hans-Peter Muhn, Katja Prelle
  • 17BETA-CYANO-19-ANDROST-4-ENE DERIVATIVE, ITS USE AND MEDICAMENTS COMPRISING THE DERIVATIVE
    Publication number: 20100292184
    Abstract: The 17?-cyano-19-androst-4-ene derivatives of the present invention possess gestagenic activity.
    Type: Application
    Filed: June 12, 2008
    Publication date: November 18, 2010
    Applicant: BAYER SCHERING PHARMA AG
    Inventors: Joachim Kuhnke, Jan Huebner, Rolf Bohlmann, Thomas Frenzel, Ulrich Klar, Frederik Menges, Sven Ring, Steffen Borden, Hans Peter Muhn, Katja Prelle
  • 1-phenyl-2-heteroaryl-substituted benzimidazole derivatives, their use for the production of pharmaceutical agents as well as pharmaceutical preparations that contain these derivatives
    Patent number: 7683081
    Abstract: New benzimidazole derivatives are described, their production and their use for the production of pharmaceutical agents for treatment and prevention of diseases that are associated with a microglia activation and T-cell-mediated immunological diseases, as well as pharmaceutical preparations that contain the new benzimidazole derivatives.
    Type: Grant
    Filed: August 4, 2005
    Date of Patent: March 23, 2010
    Assignee: Bayer Schering Pharma Aktiengesellschaft
    Inventors: Thorsten Blume, Bernd Elger, Wolfgang Halfbrodt, Joachim Kuhnke, Ursula Moenning, Herbert Schneider
  • Chk-, Pdk- and Akt-inhibitory pyrimidines, their production and use as pharmaceutical agents
    Patent number: 7504410
    Abstract: This invention relates to pyrimidine derivatives of general formula (I) as inhibitors of kinases, their production as well as their use as medications for treating various diseases.
    Type: Grant
    Filed: November 28, 2003
    Date of Patent: March 17, 2009
    Assignee: Schering Aktiengesellschaft
    Inventors: Judi Bryant, Monica J. Kochanny, Shendong Yuan, Seock-Kyu Khim, Brad O. Buckman, Damian O. Arnaiz, Ulf Bomer, Hans Briem, Peter Esperling, Christoph Huwe, Joachim Kuhnke, Martina Schafer, Lars Wortmann, Dirk Kosemund, Emil Eckle, Richard I. Feldman, Gary B. Phillips
  • 17Beta-CYANO-19-NOR-ANDROST-4-ENE DERIVATIVE, ITS USE AND MEDICAMENTS COMPRISING THE DERIVATIVE
    Publication number: 20090048217
    Abstract: The 17?-cyano-19-nor-androst-4-ene derivatives of the present invention possess gestagenic activity.
    Type: Application
    Filed: June 11, 2008
    Publication date: February 19, 2009
    Inventors: Joachim KUHNKE, Jan Huebner, Rolf Bohlmann, Thomas Frenzel, Ulrich Klar, Frederik Menges, Sven Ring, Steffen Borden, Hans-Peter Muhn, Xatja Prelle
  • 17Beta-CYANO-18A-HOMO-19-NOR-ANDROST-4-ENE DERIVATIVE, ITS USE AND MEDICAMENTS COMPRISING THE DERIVATIVE
    Publication number: 20090048218
    Abstract: The 17?-cyano-18a-homo-19-nor-androst-4-ene derivatives of the present invention possess gestagenic activity.
    Type: Application
    Filed: June 11, 2008
    Publication date: February 19, 2009
    Inventors: JOACHIM KUHNKE, JAN HUEBNER, ROLF BOHLMANN, THOMAS FRENZEL, ULRICH KLAR, FREDERIK MENGES, SVEN RING, STEFFEN BORDEN, HANS-PETER MUHN, KATJA PRELLE
  • 18-Methyl-19-norandrost-4-ene 17, 17-spiro ether (18-methyl-19-nor-20-spirox-4-en-3-one), and pharmaceutical products comprising the same
    Publication number: 20080153787
    Abstract: The present invention describes the novel 18-methyl-19-norandrost-4-ene 17,17-spiro ethers of the general formula I in which Z is an oxygen atom, two hydrogen atoms, a group ?NOR or ?NNHSO2R, where R is a hydrogen atom or a straight- or branched-chain alkyl group having 1 to 4 or 3 to 4 carbon atoms, R4 is a hydrogen atom, a halogen atom or a trifluoromethyl group, and R6 and/or R7 may have a or a configuration, and R6 and R7 are independently of one another a hydrogen atom or a straight- or branched-chain alkyl group having 1 to 4 or 3 to 4 carbon atoms or a straight- or branched-chain alkenyl group having 2 to 4 or 3 to 4 carbon atoms or a saturated cycloalkyl group having 3 to 5 carbon atoms or together are a methylene group or a double bond. The novel compounds have progestational and antimineralocorticoid activity.
    Type: Application
    Filed: June 28, 2007
    Publication date: June 26, 2008
    Inventors: Rolf BOHLMANN, Joachim Kuhnke, Jan Huebner, Norbert Gallus, Frederik Menges, Steffen Borden, Hans-Peter Muhn, Katja Prelle
  • 1,2 diarylbenzimidazoles and their pharmaceutical use
    Patent number: 7345075
    Abstract: Benzimidazoles of general formula I and the use of benzimidazole derivatives for the production of pharmaceutical agents for treatment and prophylaxis of diseases that are associated with a microglia activation are described.
    Type: Grant
    Filed: December 16, 2005
    Date of Patent: March 18, 2008
    Assignee: Schering Aktiengesellschaft
    Inventors: Wolfgang Halfbrodt, Joachim Kuhnke, Ursula Moenning
  • 1,2 Diarylbenzimidazoles and their pharmaceutical use
    Patent number: 7329679
    Abstract: Benzimidazoles of general formula I and the use of benzimidazole derivatives for the production of pharmaceutical agents for treatment and prophylaxis of diseases that are associated with a microglia activation are described.
    Type: Grant
    Filed: December 8, 2005
    Date of Patent: February 12, 2008
    Assignee: Schering Aktiengesellschaft
    Inventors: Wolfgang Halfbrodt, Joachim Kuhnke, Ursula Moenning
  • 1-aryl-2-N-, S- or O-substituted benzimidazole derivatives, their use for the production of pharmaceutical agents as well as pharmaceutical preparations that contain these derivatives
    Patent number: 7196202
    Abstract: The invention relates to novel benzimidazole derivatives with general formula I, whereby radicals R1, R2, R3, A, B, Y and Z have the meanings that are indicated in the description and the claims, the use of these compounds for the production of a pharmaceutical agent for treatment and prevention of diseases associated with microglia activation as well as pharmaceutical preparations that contain these compounds
    Type: Grant
    Filed: February 24, 2005
    Date of Patent: March 27, 2007
    Assignee: Schering AG
    Inventors: Thorsten Blume, Wolfgang Halfbrodt, Joachim Kuhnke, Ursula Monning, Herbert Schneider
  • 1,2 diarylbenzimidazoles and their pharmaceutical use
    Patent number: 7115645
    Abstract: Benzimidazoles of general formula I and the use of benzimidazole derivatives for the production of pharmaceutical agents for treatment and prophylaxis of diseases that are associated with a microglia activation are described.
    Type: Grant
    Filed: January 16, 2001
    Date of Patent: October 3, 2006
    Assignee: Schering Aktiengesellschaft
    Inventors: Wolfgang Halfbrodt, Joachim Kuhnke, Ursula Moenning
  • Microglia inhibitors for interrupting interleukin 12 and IFNgamma-mediated immune reactions
    Publication number: 20060211690
    Abstract: The invention describes the use of microglia inhibitors for the production of pharmaceutical agents that inhibit immune reactions that are mediated by monocytes, macrophages and T cells, and their use for treating T-cell-mediated immunological diseases and non-T-cell-mediated inflammation reactions.
    Type: Application
    Filed: February 9, 2006
    Publication date: September 21, 2006
    Applicant: Schering Aktiengesellschaft
    Inventors: Thorsten Blume, Wolf-Dietrich Doecke, Wolfgang Halfbrodt, Joachim Kuhnke, Ursula Moenning, Bernd Elger, Herbert Schneider
  • 1,2 Diarylbenzimidazoles and their pharmaceutical use
    Publication number: 20060205803
    Abstract: Benzimidazoles of general formula I and the use of benzimidazole derivatives for the production of pharmaceutical agents for treatment and prophylaxis of diseases that are associated with a microglia activation are described.
    Type: Application
    Filed: December 16, 2005
    Publication date: September 14, 2006
    Applicant: Schering Aktiengesellschaft
    Inventors: Wolfgang Halfbrodt, Joachim Kuhnke, Ursula Moenning
  • 1,2 Diarylbenzimidazoles and their pharmaceutical use
    Publication number: 20060094770
    Abstract: Benzimidazoles of general formula I and the use of benzimidazole derivatives for the production of pharmaceutical agents for treatment and prophylaxis of diseases that are associated with a microglia activation are described.
    Type: Application
    Filed: December 8, 2005
    Publication date: May 4, 2006
    Applicant: Schering Aktiengesellschaft
    Inventors: Wolfgang Halfbrodt, Joachim Kuhnke, Ursula Moenning
  • 1-Phenyl-2-heteroaryl-substituted benzimidazole derivatives, their use for the production of pharmaceutical agents as well as pharmaceutical preparations that contain these derivatives
    Publication number: 20050267160
    Abstract: New benzimidazole derivatives are described, their production and their use for the production of pharmaceutical agents for treatment and prevention of diseases that are associated with a microglia activation and T-cell-mediated immunological diseases, as well as pharmaceutical preparations that contain the new benzimidazole derivatives.
    Type: Application
    Filed: August 4, 2005
    Publication date: December 1, 2005
    Applicant: Schering Aktiengesellschaft
    Inventors: Thorsten Blume, Wolfgang Halfbrodt, Joachim Kuhnke, Ursula Moenning, Bernd Elger, Herbert Schneider
  • 1-phenyl-2-heteroaryl-substituted benzimdazole derivatives, their use for the production of pharmaceutical agents as well as pharmaceutical preparations that contain these derivatives
    Patent number: 6962932
    Abstract: New benzimidazole derivatives are described, their production and their use for the production of pharmaceutical agents for treatment and prevention of diseases that are associated with a microglia activation and T-cell-mediated immunological diseases, as well as pharmaceutical preparations that contain the new benzimidazole derivatives.
    Type: Grant
    Filed: February 14, 2003
    Date of Patent: November 8, 2005
    Assignee: Schering Aktiengesellschaft
    Inventors: Thorsten Blume, Wolfgang Halfbrodt, Joachim Kuhnke, Ursula Moenning, Bernd Elger, Herbert Schneider
  • 1-Aryl-2-N-, S- or O-substituted benzimidazole derivatives, their use for the production of pharmaceutical agents as well as pharmaceutical preparations that contain these derivatives
    Publication number: 20050143439
    Abstract: The invention relates to novel benzimidazole derivatives with general formula I, whereby radicals R1, R2, R3, A, B, Y and Z have the meanings that are indicated in the description and the claims, the use of these compounds for the production of a pharmaceutical agent for treatment and prevention of diseases associated with microglia activation as well as pharmaceutical preparations that contain these compounds.
    Type: Application
    Filed: February 24, 2005
    Publication date: June 30, 2005
    Applicant: Schering Aktiengesellschaft
    Inventors: Thorsten Blume, Wolfgang Halfbrodt, Joachim Kuhnke, Ursula Monning, Herbert Schneider
  • 1-Aryl-2-N-, S- or O-substituted benzimidazole derivatives, their use for the production of pharmaceutical agents as well as pharmaceutical preparations that contain these derivatives
    Patent number: 6903126
    Abstract: The invention relates to novel benzimidazole derivatives with general formula I, whereby radicals R1, R2, R3, A, B, Y and Z have the meanings that are indicated in the description and the claims, the use of these compounds for the production of a pharmaceutical agent for treatment and prevention of diseases associated with microglia activation as well as pharmaceutical preparations that contain these compounds
    Type: Grant
    Filed: July 9, 2002
    Date of Patent: June 7, 2005
    Assignee: Schering AG
    Inventors: Thorsten Blume, Wolfgang Halfbrodt, Joachim Kuhnke, Ursula Monning, Herbert Schneider
  • 1-alkyl-2-aryl-benzimidazole derivatives, their use for the production of pharmaceutical agents as well as pharmaceutical preparations that contain these derivatives
    Patent number: 6855714
    Abstract: The invention relates to novel benzimidazole derivatives with general formula I, whereby radicals R1, R2, R3, A, B and Y have the meanings that are indicated in the description and the claims, the use of these compounds for the production of a pharmaceutical agent for treating and for preventing diseases that are associated with microglia activation, as well as pharmaceutical preparations that contain these compounds.
    Type: Grant
    Filed: July 5, 2002
    Date of Patent: February 15, 2005
    Assignee: Schering Aktiengesellschaft
    Inventors: Thorsten Blume, Wolfgang Halfbrodt, Joachim Kuhnke, Ursula Moenning, Herbert Schneider, Bernd Elger
  • Chk-, Pdk- and Akt-inhibitory pyrimidines, their production and use as pharmaceutical agents
    Publication number: 20040186118
    Abstract: This invention relates to pyrimidine derivatives of general formula (I) as inhibitors of kinases, their production as well as their use as medications for treating various diseases
    Type: Application
    Filed: November 28, 2003
    Publication date: September 23, 2004
    Inventors: Judi Bryant, Monica J. Kochanny, Shendong Yuan, Seock-Kyu Khim, Brad O. Buckman, Damian O. Arnaiz, Ulf Bomer, Hans Briem, Peter Esperling, Christoph Huwe, Joachim Kuhnke, Martina Schafer, Lars Wortmann, Dirk Kosemund, Emil Eckle, Richard J. Feldman, Gary B. Phillips