Abstract: The present invention relates to a composition comprising a binder comprising one or more siloxane polymers, silicone resins, silicone based elastomers, and mixtures thereof, wherein said binder optionally comprises one or more cross-linker components comprising a silane and/or a siloxane containing silicon-bonded hydrolysable groups; and a hydrophilic powder and/or gel selected from one or more amorphous, porous hydrophilic silica (s) having a thermal conductivity at 20° C. and atmospheric pressure of 0.001 to 0.15 W/m·K and a surface area (SBET) of between 200 and 1500 m2/g, one or more hydrophilic aerogel (s) and mixtures thereof, wherein the binder is a solution, an emulsion, or a dispersion in water. The invention also relates to the use of the composition as or in thermally or acoustically insulating materials and to coated substrates, products and articles made by using the composition.

Abstract: An installation assembly for a loudspeaker, in particular in a vehicle door, contains a support element having a receiving opening for the loudspeaker, a loudspeaker basket having a flange, and a sealing element in the region of a mechanical abutment interface between the loudspeaker basket and the support element. During installation, the loudspeaker extends through the receiving opening on the support side, and the flange on the basket side abuts the support element with the interposition of the sealing element. The loudspeaker basket has a number of joining elements which correspond to joining contours of the support element to produce a bayonet coupling or a push-and-turn connection.

Abstract: The present invention relates to a composition comprising a binder comprising one or more siloxane polymers, silicone resins, silicone based elastomers, and mixtures thereof, wherein said binder optionally comprises one or more cross-linker components comprising a silane and/or a siloxane containing silicon-bonded hydrolysable groups; and a hydrophilic powder and/or gel selected from one or more amorphous, porous hydrophilic silica(s),one or more hydrophilic silica aerogel (s) and mixtures thereof, said amorphous, porous hydrophilic silica and/or said hydrophilic silica aerogel having a BET surface area from 100 m2/g to 1500 m2/g or greater and a thermal conductivity from 0.004 to 0.05 W/m·K at 20° C. and atmospheric pressure. The invention also relates to the use of said composition as or in thermally or acoustically insulating materials and to coatings, products and articles made therefrom.

Abstract: The present invention relates to a composition comprising a binder comprising one or more siloxane polymers, silicone resins, silicone based elastomers, and mixtures thereof, wherein said binder optionally comprises one or more cross-linker components comprising a silane and/or a siloxane containing silicon-bonded hydrolysable groups; and a hydrophilic powder and/or gel selected from one or more amorphous, porous hydrophilic silica(s), one or more hydrophilic silica aerogel(s) and mixtures thereof, said amorphous, porous hydrophilic silica and/or said hydrophilic silica aerogel having a BET surface area from 100 m2/g to 1500 m2/g or greater and a thermal conductivity from 0.004 to 0.05 W/m·K at 20° C. and atmospheric pressure. The invention also relates to the use of said composition as or in thermally or acoustically insulating materials and to coatings, products and articles made therefrom.

Abstract: A vehicle door includes a wet space provided within the vehicle door, which is separated from a dry space on the vehicle door, wherein the vehicle door includes at least a door skin that borders the wet space and dry space, a speaker, and a resonance body component configured to form a resonance space for the speaker, wherein the resonance body component defines a closed volume for the resonance space in the wet space of the vehicle door.

Abstract: The present invention relates to the use of human anti-inflammatory peptides in the inhalatory treatment of inflammatory pulmonary diseases. The invention in particular relates to the use of vasoactive intestinal peptide, C-type natriuretic peptide, B-type natriuretic peptide, pituitary adenylate cyclase-activating peptide, adrenomedullin, alpha-melanocyte stimulating hormone, relaxin and Interferon gamma for said purposes. Advantageous features of an aerosol containing such a human anti-inflammatory peptide and a method for producing said aerosol are disclosed. The present invention further relates to a kit for inhalatory treatment of inflammatory pulmonary diseases. One aspect relates to treatment of CoViD-19 related ARDS.

Abstract: A mixer assembly unit, especially for an exhaust system of an internal combustion engine of a vehicle, includes a mixer body (48) with an incoming flow side (58) and with an outgoing flow side (60); and a carrier element (24) with a carrier element body (44) enclosing the mixer body (48) radially on an outside in relation to a mixer longitudinal axis. The mixer body (48) includes a plurality of flow deflection elements (62) and at least one holding area (70). The carrier element (24) includes a counter holding area (46) in association with a holding area (70). The counter holding area (46) is connected in substance to the holding area (70). The counter holding area (46) overlaps the holding area (70) at least partly radially on a side oriented in a direction of the outgoing flow side (60) of the mixer body (48).

Abstract: Checkpoint inhibitor-induced pneumonitis (CIP) is characterized clinically by dyspnea, cough and tachypnea. Hypoxia results from a lymphocyte-dominated alveolitis leading to ground glass opacities and consolidations observed by CT scan. Histological findings include lymphocytic infiltrates, granuloma formation and eosinophilic accumulation. In the management of CIP, systemic administration of steroids such as methylprednisolone is the standard therapy. Moreover, CIP in most cases leads to discontinuation of checkpoint inhibitory therapy and steroids limit the therapeutic effect of checkpoint inhibitors resulting in progression of the underlying malignant disease. Therefore, there is a need of other therapeutic options in CIP that ideally could abrogate the alveolar inflammation induced by checkpoint inhibitors without affecting the systemic effect on the immune system.

Abstract: A pipe, especially an internal combustion engine, exhaust system, exhaust gas-guiding pipe, includes a connection area (26). The connection area (26) is at an axial pipe end (12) for connecting the pipe (14) extending in a pipe longitudinal axis (A) to another pipe (16) to be pushed into the connection area (26). The connection area (26) includes two slots (18a, 18b). The slots (18a, 18b) include a first slot area (20a, 20b), located closer to the pipe end (12), and a second slot area (22a, 22b), located axially farther away from the pipe end (12) and offset in a circumferential direction in relation to the first slot area (20a, 20b). The second slot areas (22a, 22b) of the two slots (18a, 18b) are offset toward one another or away from one another in the circumferential direction in relation to the first slot areas (20a, 20b).

Abstract: The present invention relates to an isolated soluble CCR6 receptor polypeptide capable of binding to CCL18 and/or CCL20 and to a method for quantifying the concentration of a soluble CCR6 receptor polypeptide in a liquid sample from a subject. The present invention also relates to a method for detecting and/or prognosticating an interstitial lung disease or a cancer in a subject by determining the level of a soluble CCR6 receptor polypeptide in a sample from said subject and further provides a pharmaceutical composition comprising a compound capable of inhibiting the activity and/or the expression of CCL18 or CCL20 for the treatment of said diseases. The present invention further relates to an isolated polypeptide capable of binding to and inhibiting the activity of the chemokine receptor CCR6 and to a method for identifying further inhibitors of CCR6 receptor activity.

Abstract: The present invention relates to a composition comprising a binder comprising one or more siloxane polymers, silicone resins, silicone based elastomers, and mixtures thereof, wherein said binder optionally comprises one or more cross-linker components comprising a silane and/or a siloxane containing silicon-bonded hydrolysable groups; and a hydrophilic powder and/or gel selected from one or more amorphous, porous hydrophilic silica(s), one or more hydrophilic silica aerogel(s) and mixtures thereof, said amorphous, porous hydrophilic silica and/or said hydrophilic silica aerogel having a BET surface area from 100 m2/g to 1500 m2/g or greater and a thermal conductivity from 0.004 to 0.05 W/mK at 20° C. and atmospheric pressure. The invention also relates to the use of said composition as or in thermally or acoustically insulating materials and to coatings, products and articles made therefrom.

Abstract: The present invention relates to a composition comprising a binder comprising one or more siloxane polymers, silicone resins, silicone based elastomers, and mixtures thereof, wherein said binder optionally comprises one or more cross-linker components comprising a silane and/or a siloxane containing silicon-bonded hydrolysable groups; and a hydrophilic powder and/or gel selected from one or more amorphous, porous hydrophilic silica (s) having a thermal conductivity at 20° C. and atmospheric pressure of 0.001 to 0.15 W/m·K and a surface area (SBET) of between 200 and 1500 m2/g, one or more hydrophilic aerogel (s) and mixtures thereof, wherein the binder is a solution, an emulsion, or a dispersion in water. The invention also relates to the use of the composition as or in thermally or acoustically insulating materials and to coated substrates, products and articles made by using the composition.

Abstract: The present invention relates to an isolated soluble CCR6 receptor polypeptide capable of binding to CCL18 and/or CCL20 and to a method for quantifying the concentration of a soluble CCR6 receptor polypeptide in a liquid sample from a subject. The present invention also relates to a method for detecting and/or prognosticating an interstitial lung disease or a cancer in a subject by determining the level of a soluble CCR6 receptor polypeptide in a sample from said subject and further provides a pharmaceutical composition comprising a compound capable of inhibiting the activity and/or the expression of CCL18 or CCL20 for the treatment of said diseases. The present invention further relates to an isolated polypeptide capable of binding to and inhibiting the activity of the chemokine receptor CCR6 and to a method for identifying further inhibitors of CCR6 receptor activity.

Abstract: A method and device for operating an x-ray device including an x-ray emitter and an x-ray detector are provided. An alternating magnetic field is produced and emitted at the x-ray emitter. At least two sensors are included for capturing at least one physical variable correlating with the alternating magnetic field. An alignment of the x-ray detector relative to the x-ray emitter is determined based on the measurement.

Abstract: The invention relates to a sensor (300) for determining a dielectric property of a medium (205). The sensor (300) has a substrate (301, 302), which has at least one via (203, 204), and a waveguide (12), which is arranged so as to be planar in relation to an upper surface of the substrate (301). The waveguide (12) can be connected to an analysis device (20) by means of the at least one via (203, 204). Furthermore, the waveguide (12) is designed to receive an input signal from the analysis device (20) and to output an output signal to the analysis device (20). When of the waveguide (12) is in contact with a medium (205), properties of the input signal and of the output signal are indicative of the dielectric property of the medium (205). The arrangement of the waveguide (12) so as to be planar in relation to the substrate (301) enables larger measurement ranges and improved measurement accuracies. Furthermore, a compact construction is achieved by the planar structure.

Abstract: A pipe, especially an internal combustion engine, exhaust system, exhaust gas-guiding pipe, includes a connection area (26). The connection area (26) is at an axial pipe end (12) for connecting the pipe (14) extending in a pipe longitudinal axis (A) to another pipe (16) to be pushed into the connection area (26). The connection area (26) includes two slots (18a, 18b). The slots (18a, 18b) include a first slot area (20a, 20b), located closer to the pipe end (12), and a second slot area (22a, 22b), located axially farther away from the pipe end (12) and offset in a circumferential direction in relation to the first slot area (20a, 20b). The second slot areas (22a, 22b) of the two slots (18a, 18b) are offset toward one another or away from one another in the circumferential direction in relation to the first slot areas (20a, 20b).

Abstract: The invention relates to an inductive charging device having at least one inductive charging coil wound about a coil axis, and an electric or dielectric antenna, which is arranged at a location that is shifted parallel to the coil axis in relation to a location of a region of the charging coil, a location within the at least one charging coil, or a location between the charging coils. The electric vehicle and the charging station each have such an inductive charging device. With the method, one or two such inductive charging devices are used, wherein by means of the inductive charging coils, energy is transmitted, and by means of the antennas, communications data are transmitted.

Abstract: A communication device is provided for identifying and/or locating an RFID transponder. The communication device includes a first RFID reader and at least one second RFID reader. The first and/or the at least one second RFID reader is configured to send out a query signal to the RFID transponder and to receive a response signal from the RFID transponder. The communication device also includes a trigger device configured to send a trigger signal to the first and/or the at least one second RFID reader, and as a result of which, the first and/or the at least one second RFID reader is configured to send out the query signal.

Abstract: The present embodiments relate to a device and a method for determining at least one concentration of coal particles in a gas flow flowing through a channel, wherein at least part of the gas flow having coal particles contained therein is measured by at least one microwave sensor and at least one measurement signal characterizing the concentration of the coal particles is provided, wherein an autocorrelation function of the measurement signal is determined and at least one distance value characterizing a distance of a point of the gas flow belonging to the concentration from the microwave sensor is determined in dependence on the autocorrelation function.

Abstract: A mixer assembly unit, especially for an exhaust system of an internal combustion engine of a vehicle, includes a mixer body (48) with an incoming flow side (58) and with an outgoing flow side (60); and a carrier element (24) with a carrier element body (44) enclosing the mixer body (48) radially on an outside in relation to a mixer longitudinal axis. The mixer body (48) includes a plurality of flow deflection elements (62) and at least one holding area (70). The carrier element (24) includes a counter holding area (46) in association with a holding area (70). The counter holding area (46) is connected in substance to the holding area (70). The counter holding area (46) overlaps the holding area (70) at least partly radially on a side oriented in a direction of the outgoing flow side (60) of the mixer body (48).