Patent number: 6387921
Abstract: Substituted 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocines of general formula 1:
wherein:
R1 and R2, which are identical or different, are each hydrogen, C1-C6-alkyl, C1--C6-alkyloxy, OH, F, Cl, or Br;
R3 is hydrogen, F, Cl, Br, methyl, ethyl, OH, or methoxy;
R4 and R5, which are identical or different, are each hydrogen, methyl, or ethyl;
R6 is hydrogen;
X is NH2, NH—(C1-C6-alkyl), N(C1-C6-alkyl)2, the two C1-C6-alkyl groups of which are identical or different, NH—COH, NH—CO(C1-C6-alkyl), or F;
A is —(CH2)3—, —CH2—CH2—O—, —CH2—O—CH2—, —(CH2)4—, —CH(C1-C6-alkyl)-O—CH2—, —(CH2)2—O—CH2—, —(CH2)3—O—, —(CH2)5—, —CH2—O—(CH2)3—, —(CH2)2—O—(CH2)2—, —(CH2)3—O—CH2—, —(CH2)4—O—, —CH2—O—CH2—CH2—O—,
Type:
Grant
Filed:
November 27, 2001
Date of Patent:
May 14, 2002
Assignee:
Boehringer Ingelheim Pharma KG
Inventors:
Matthias Grauert, Adrian Carter, Thomas Weiser, Helmut Ensinger, Wolfram Gaida, Joachim Mierau
Patent number: 6355652
Abstract: Substituted 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocines of general formula 1:
wherein:
R1 and R2, which may be identical or different, are each hydrogen, C1-C6-alkyl, C1-C6-alkyloxy, OH, F, Cl, or Br;
R3 is hydrogen, F, Cl, Br, methyl, ethyl, OH, or methoxy;
R4, R5, and R6, which may be identical or different, are each hydrogen, methyl, or ethyl;
X is NH2, NH-(C1-C6-alkyl), N(C1-C6-alkyl)2, the two C1-C6-alkyl groups of which may be identical or different, NH—COH, NH—CO(C1-C6-alkyl), or F;
A is —(CH2)3—, —CH2—CH2—O—, —CH2—O—CH2—, —(CH2)4—, —CH(C1-C6-alkyl)-O—CH2—, —(CH2)2—O—CH213 , —(CH2)3—O—, —(CH2)5—, —CH2—O—(CH2)3—, —(CH2)2—O—(CH2)2—, —(CH2)3—O—CH2—, —(CH2)4—O—, —CH2—O—CH2—CH2—O—,
the
Type:
Grant
Filed:
October 30, 2000
Date of Patent:
March 12, 2002
Assignee:
Boehringer Ingelheim Pharma KG
Inventors:
Matthias Grauert, Adrian Carter, Thomas Weiser, Helmut Ensinger, Wolfram Gaida, Joachim Mierau