Patents by Inventor Joachim Rehse

Joachim Rehse has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROCESS FOR PREPARING METHYL CARBAMATE AND ITS PURIFICATION FOR USE AS PHARMACEUTICALLY ACTIVE COMPOUND
    Publication number: 20110130411
    Abstract: The present invention relates to processes for preparing methyl {4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}carbamate, i.e. the compound of the formula (I) and to a process for purifying the crude product of the formula (I) for use as pharmaceutically active compound, where, for purification, methyl {4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}carbamate sulphinyldimethane (1:2) of the formula (II) is isolated as intermediate or is generated as intermediate in this purification process, if appropriate present in a mixture.
    Type: Application
    Filed: November 29, 2010
    Publication date: June 2, 2011
    Applicant: BAYER SCHERING PHARMA AKTIENGESELLSCHAFT
    Inventors: Franz-Josef MAIS, Joachim REHSE, Winfried JOENTGEN, Konrad SIEGEL
  • PROCESS FOR PREPARING METHYL METHYLCARBAMATE AND ITS PURIFICATION FOR USE AS PHARMACEUTICALLY ACTIVE COMPOUND
    Publication number: 20110130410
    Abstract: The present invention relates to a process for preparing methyl {4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}methylcarbamate of the formula (I) and to a process for purifying the crude product of the compound of the formula (I) for use as pharmaceutically active compound, where, for purification, methyl {4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}methylcarbamate sulphinyldimethane (1:1), i.e. a compound of the formula (II), is isolated as intermediate or is generated as intermediate in this purification process, if appropriate present in a mixture.
    Type: Application
    Filed: November 29, 2010
    Publication date: June 2, 2011
    Applicant: BAYER SCHERING PHARMA AKTIENGESELLSCHAFT
    Inventors: Franz-Josef MAIS, Joachim REHSE, Winfried JOENTGEN, Konrad SIEGEL
  • Preparation process
    Patent number: 7351823
    Abstract: The present invention relates to a process for preparing 5-chloro-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1,3-oxazolidin-5-yl}methyl)-2-thiophenecarboxamide starting from 2-[(2S)-2-oxiranylmethyl]-1H-isoindole-1,3(2H)-dione, 4-(4-aminophenyl)-3-morpholinone and 5-chlorothiophene-2-carbonyl chloride.
    Type: Grant
    Filed: January 10, 2005
    Date of Patent: April 1, 2008
    Assignee: Bayer HealthCare AG
    Inventors: Mathias Berwe, Christian Thomas, Joachim Rehse, Dirk Grotjohann
  • Preparation process
    Publication number: 20050182055
    Abstract: The present invention relates to a process for preparing 5-chloro-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1,3-oxazolidin-5-yl}methyl)-2-thiophenecarboxamide starting from 2-[(2S)-2-oxiranylmethyl]-1H-isoindole-1,3(2H)-dione, 4-(4-aminophenyl)-3-morpholinone and 5-chlorothiophene-2-carbonyl chloride.
    Type: Application
    Filed: January 10, 2005
    Publication date: August 18, 2005
    Applicant: Bayer HealthCare AG
    Inventors: Mathias Berwe, Christian Thomas, Joachim Rehse, Dirk Grotjohann
  • Process for the preparation of specific aromatic aldehydes
    Publication number: 20030232989
    Abstract: A new process for the preparation of specific aromatic aldehydes by ozonolysis of aromatic alkenes is provided. This new process can be advantageously integrated into a synthesis of specific chiral diols using aromatic aldehydes of this type.
    Type: Application
    Filed: April 14, 2003
    Publication date: December 18, 2003
    Inventors: Stefan Antons, Joachim Rehse, Herbert Diehl, Christian Laue
  • Process for preparing sodium 3R,5S-(+)-erythro-(E)-7- 4-(4-fluorophenyl)-2,6-diisopropyl-5-methoxymet hyl-pyrid-3-yl!-3,5-dihydroxy-hept-6-enoate
    Patent number: 5502199
    Abstract: Enantiomerically pure sodium 3R,5S-(+)-erythro-(E)-7- 4-(4-fluorophenyl)-2,6-diisopropyl-5-methoxy-meth yl-pyrid-3-yl!-3,5-dihydroxy-hept-6-enoate is prepared by initially cyclizing a corresponding racemic ester to give the racemic lactones and then separating the latter by chromatography on a chiral stationary phase. Cleavage of the enantiomerically pure lactones with the aid of a base yields the enantiomerically pure end products.
    Type: Grant
    Filed: March 17, 1994
    Date of Patent: March 26, 1996
    Assignee: Bayer Aktiengesellschaft
    Inventors: Rolf Angerbauer, Rolf Grosser, Werner Hinsken, Joachim Rehse