Abstract: The invention relates to a novel GAFA domain-containing polypeptide, to the GAFA domain of a human phosphodiesterase 11 (PDE11) and to the adenylate cyclase catalytic domain. The use of said polypeptide in a method for identifying PDE-11 modulators is also disclosed.

Abstract: The invention relates to a novel polypeptide containing the GAFA-domain and GAFB-domain of a human phosphodiesterase 5 (PDE5) and the catalytic domain of an adenylate cyclase, and to the use of this polypeptide in a method for identifying PDE5-modulators.

Abstract: The invention relates to a protein, which comprises an adenylate cyclase domain in addition to an ion channel domain. The ion channel domain is preferably a potassium ion channel domain, which is sensitive to voltage. In addition, the protein has a C-terminal protein-protein interaction domain. The invention also relates to nucleotide sequences, which code for proteins of this type.

Abstract: The invention relates to a headbox for a paper machine, comprising: a plurality of distributor-dampening devices; each distributor-dampening device comprising an upright vessel, said vessel having at its bottom a central inlet for feeding of a pulp suspension, a plurality of sectional flow pipes, each being located at the same height and arranged unitormly around the circumference of the said vessel, further comprising dilution water lines for metering of dilution water into each sectional flow pipe; a forming unit having a slit shaped outlet channel extending at least approximately over the width of the paper machine for dispensing of a flat stream of pulp suspension; the sectional flow pipes of each of the distributors being connected to the outlet channel, each of the said sectional flow pipes at least of approximately have the same length.

Abstract: A method for expression of membrane proteins is provided, wherein at least a portion of a nucleotide sequence coding to the membrane protein is fused to at least a portion of a nucleotide sequence coding for an adenylyl cyclase of Mycobacterium tuberculosis or a sequence at least about 70% identical to said sequence of Mycobacterium tuberculosis. In a second step the fused nucleotide sequence is introduced into an organism and/or a living cell. Another aspect of the invention is a method for searching active agents, which interact directly with adenylyl cyclases.

Abstract: The invention relates to the isolation of the prepro form of cathepsin L, of its leader sequence, of cathepsin L and of the affiliated propeptide from ciliates, in particular Paramecium, to the use of these peptides and to a process for preparing cathepsin L from ciliates.

Abstract: The invention relates to the isolation of the prepro form of cathepsin L, of its leader sequence, of cathepsin L and of the affiliated propeptide from ciliates, in particular Paramecium, to the use of these peptides and to a process for preparing cathepsin L from ciliates.

Abstract: The invention relates to the isolation of the prepro form of cathepsin L, of its leader sequence, of cathepsin L and of the affiliated propeptide from ciliates, in particular Paramecium, to the use of these peptides and to a process for preparing cathepsin L from ciliates.

Abstract: A controlled deflection roll possesses a roll shell which is radially movable in at least one plane in relation to a roll support. Position feelers or sensors are arranged at the ends of the roll shell. These position feelers control regulators operatively associated with pressure or support elements located between the roll support and the roll shell, as a function of deviations from a predetermined reference or set position, in a manner such that the roll shell is maintained in the reference or set position. It is possible to influence the pressure or support elements by the position feelers either equally or unequally, and specifically, with decreasing intensity in the presence of increasing distance from the related position feeler.

Abstract: A method of, and apparatus for, measuring the throughflow quantity of a liquid substance per unit of time in a papermaking machine, wherein the measurement is undertaken on the basis of the pressure drop at a throttling element, there being used as the throttling element a perforated plate having a multiplicity of parallel channels through which the substance flows.

Abstract: The damping device has a transition section of increasing cross-sectional area with a perforated plate extending across the downstream end. The perforated plate has ducts which increase in cross-sectional area in a step-wise manner. The transition section may have a parabolic profile, a conical profile, an arcuate profile or may be formed of a sequence of conical parts.

Abstract: The head box is provided with a distributor having a plurality of pulp distributing ducts which have terminal sections converging towards the throat of the box. The distributing ducts also have step-like widenings upstream of the terminal sections to create a strong turbulence in the pulp flow to maintain the solids content of the pulp in suspension. The terminal sections terminate short of the throat so as to reduce any risk of cross-flow and thus improve the flow of the pulp.

Abstract: The distribution pipe is of narrowing circular cross-section with an elongated aperture. The pulp guide is mounted via a tongue and groove connection on the pipe to both sides of the aperture in order to hold the pipe together against the peripherally operative tangential force of the pipe. The plates which form the throat can be replaced from time-to-time to change the size of the throat.

Abstract: The auxiliary roll of the separating system is located downstream of the main roll and is spaced from the main roll at a distance less than 0.25 times the diameter of the auxiliary roll and greater than the combined thickness of the two wires and paper web therebetween, e.g. a distance of 10 millimeters. A separating wall is located between the main roll and main wire on the upstream side to block the entry of air between the main wire and main roll. The spacing of the two rolls ensures a positive separation of the paper web on the main wire.