Abstract: The present invention encompasses compounds of formula (I) wherein R1a, R1b, R2a, R2b, Z, R3 to R5, ring A, ring B, p, q, V and W have the meanings given in the claims and specification, their use as inhibitors of KRAS, pharmaceutical compositions and preparations containing such compounds and their use as medicaments/medical uses, especially as agents for treatment and/or prevention of oncological diseases.

Abstract: A resource control system for networked devices in which the subscribers of the networked devices do not trust one another is provided. Also provided is a distributed data bank system, which, for example, is implemented by a blockchain.

Abstract: A resource control system for networked devices in which the subscribers of the networked devices do not trust one another is provided. Also provided is a distributed data bank system, which, for example, is implemented by a blockchain.

Abstract: Various embodiments include an asset tracking system for tracking an asset in an asset-based industrial process involving the asset passing between a plurality of realms comprising: a distributed database system configured to host a consensus-based ledger of transactional records; a plurality of asset tracking devices each configured to acquire one or more asset attribute values of the asset, wherein each of the realms includes at least one of the plurality of asset tracking devices; and an asset lifetime handler device configured to maintain, in the ledger of the distributed database system, based on the asset attribute values respectively acquired over time by a respective one of the plurality of asset tracking devices, an asset lifetime passport (ALP) comprising a digital representation of a history of the acquired asset attribute values of the asset.

Abstract: A method operates a network management system comprising nodes which are used as manager and/or agent nodes. At least one node communicates with at least one other node using a peer-to-peer protocol. A network management system and a node in a management network system are used to carry out said method.

Abstract: Data are transmitted in a data network modelled by layers that include a transport layer, a plurality of upper layers above the transport layer and a plurality of lower layers below the transport layer, where the transport layer contains data from the upper layers.

Abstract: The method makes it possible to image a quality of service feature (distinguishing between high-priority and low-priority data streams) that is available in a connection-oriented communication network into a connectionless communication network. The application is the connection of an ATM network to a local area network (LAN), whereby the LAN has the aforementioned quality of service feature available to it and a distinction between high-priority data streams and low-priority data streams is possible with an imaging rule beyond the boundary ATM-LAN.