Abstract: The invention relates to a method for producing magnetic nanoparticles which are made of metal oxide-polymer composites and are provided with an increased magnetic mobility, among other things, due the high metal oxide content and the morphological structure thereof. High-pressure homogenization has proven to be a reliable technique for producing the inventive magnetic nanoparticles. According to said technique, the components metal oxide and polymer are processed in a carrier medium. Water is used in most cases at pressures ranging from 500 bar to 1200 bar while using great shearing forces. High pressure homogenization creates a colloidally stable magnetic particle population having a diameter ranging below 200 nm while also resulting in the produced magnetic nanoparticles being provided with greater magnetic moments than the metal oxide used as an initial material at low magnetic field strengths.

Abstract: Magnetic nanoparticles exhibiting enhanced heating ability in thermotherapeutic applications are described, as are several strategies to conjugate such nanoparticles. Methods for using conjugated nanoparticles are also provided.

Abstract: The invention relates to a method for producing magnetic nanoparticles which are made of metal oxide-polymer composites and are provided with an increased magnetic mobility, among other things, due the high metal oxide content and the morphological structure thereof. High-pressure homogenization has proven to be a reliable technique for producing the inventive magnetic nanoparticles. According to said technique, the components metal oxide and polymer are processed in a carrier medium. Water is used in most cases at pressures ranging from 500 bar to 1200 bar while using great shearing forces. High pressure homogenization creates a colloidally stable magnetic particle population having a diameter ranging below 200 nm while also resulting in the produced magnetic nanoparticles being provided with greater magnetic moments than the metal oxide used as an initial material at low magnetic field strengths.

Abstract: Disclosed are biocompatible magnetic nanoparticle compositions for various therapeutic or biological applications, and methods related thereto. Specifically, the present invention pertains to magnetic nanoparticle compositions prepared via high-pressure homogenization processes that include a turbulent flow zone. The methods of production may involve a two-step or a one-step process. The disclosed magnetic nanoparticle compositions may be useful in the treatment of the body, body part, tissue, cell, or body fluid of a subject for a variety of indications. The disclosed magnetic nanoparticle compositions may also be useful in the fixation, separation, transportation, marking or coding of targets, or energy transformation processes.

Abstract: A process for preparing a patient-specific immunoadsorber, which comprises (i) extracting a body fluid from a patient having an immunopathological condition, the fluid containing immune complexes that are relevant to that immunopathological condition, (ii) contacting the extracted fluid with an adsorbent for the immune complexes to form adsorbed immune complexes, (iii) eluting the adsorbed complexes to form an eluate, (iv) fractionating the eluate into a plurality of immune complex component fractions, and (v) immobilizing the immune complex components on one or more biologically compatible carriers activated to bond to its surface one or more desired immune complex components.

Abstract: This invention relates to biocompatible and biodegradable polymers which are able to bind diagnostic and therapeutic radioisotopes, and the therapeutic use of the same as well as the synthesis of such polymers. It further relates to the preparation of functional implants from these materials, including nanospheres, microspheres, liposomes, micelles, coatings, films, fibers, and foils.

Abstract: The invention relates to biodegradable polymeric composite material for the production of micro-capsules containing any kind of substances, e.g. foodstuffs, medicine and immunogens or technical materials such as oils, colorants, enzymes or similar.

Abstract: The invention concerns a method for the electrochemical deposition of hydroxyapatite layers onto metal and ceramic surfaces, the actual electrochemical coating being combined with a pre-coating of the substrates by sol-gel processes, using a calcium and (hydrogen) phosphate-containing electrolyte by means of pulsed direct current. Materials coated in this way are used in the form of biocompatible implants in human and veterinary medicine and are distinguished by particularly high grow-in rates. In contrast to conventional methods of generating hydroxyapatite layers (conventional or microwave sintering of hydroxyapatite produced by the wet-chemical method, deposition by other electrochemical, plasma or laser-aided methods or by sol-gel techniques), this method is distinguished by the application of uniform hydroxyapatite coatings which adhere well and have a small amorphous portion and an optimum layer thickness (5-25 .mu.