Abstract: The invention concerns a novel pharmaceutical preparation and methods of treatment associated therewith. More particularly, the invention is concerned with pharmaceutical preparations adapted to form or release resorbable bicarbonate ions only in the intestine of the subject. The oral dosage forms of the invention may comprise further active agents, and trace elements.The dosage forms are for example useful in treating patients suffering from abnormal distribution or retention of body fluids or retention products, i.e. products which should be or which should desirably be cleared by kidney function.

Abstract: The invention concerns a method of treating a subject suffering from abnormal distribution and retention of body fluids such as may be the result of altered renal function, which comprises the step of administering to a subject in need of such treatment, a therapeutically effective amount of a pharmaceutically acceptable alkaline acting substance capable of increasing patient plasma bicarbonate level to a value in excess of that prior to treatment.Oral preparations, in particular an alkaline substance capable of releasing bicarbonate ions, for therapy of a large variety of ailments and diseases, are disclosed.