Abstract: The present invention provides multitargeting bispecific antigen-binding molecules characterized by comprising a first and a second bispecific entity each comprising a domain binding to target, a second domain binding to an extracellular epitope of the human and the Macaca CD3? chain, wherein both bispecific entities are linked to each other by a spacer which spaces apart the first and the second bispecific entity. Moreover, the invention provides a polynucleotide, encoding the multitargeting bispecific antigen-binding molecule, a vector comprising this polynucleotide, host cells, expressing the construct and a pharmaceutical composition comprising the same.

Abstract: The present invention provides bispecific antibody constructs characterized by comprising a first domain binding to MUC17, a second domain binding to an extracellular epitope of the human and the Macaca CD3E chain and optionally a third domain, which is a specific Fc modality. Moreover, the invention provides a polynucleotide, encoding the antibody construct, a vector comprising this polynucleotide, host cells, expressing the construct and a pharmaceutical composition comprising the same.

Abstract: An exchangeable sweeping brush device for a carrier vehicle is provided. The device has at least one sweeping brush which is rotationally drivable about an almost vertically oriented axis of rotation of the brush and is held on a supporting frame, the supporting frame being detachably connectable to a supporting fork of the carrier vehicle, which is pivotable about a first horizontal pivot axis oriented transversely to the longitudinal axis of the vehicle. The supporting frame comprises a first supporting assembly on which the at least one sweeping brush is rotatably mounted, and a second supporting assembly which is detachably connectable to the supporting fork, the first supporting assembly being connected to the second supporting assembly for pivotal movement about a second horizontal pivot axis and being detachably connectable to the carrier vehicle by at least one tension member. A sweeper having such a sweeping brush device is also proposed.

Abstract: The invention relates to an automotive sweeper with wheels for traveling along a ground surface and with at least one sweeping brush rotatingly drivable for sweeping the ground surface and with a dirt container adapted to be acted upon with a vacuum by a suction unit via a suction conduit and connected to a suction port via an intake line for the purpose of receiving sweepings. In order to develop the sweeper further in such a manner that it achieves an improved cleaning result with as little use of energy as possible it is suggested in accordance with the invention that the suction conduit be integrated into the dirt container at least in sections, wherein the outlet of the intake line opening into the dirt container is arranged next to at least one inlet area of the suction conduit.

Abstract: An exchangeable sweeping brush device for a carrier vehicle is provided. The device has at least one sweeping brush which is rotationally drivable about an almost vertically oriented axis of rotation of the brush and is held on a supporting frame, the supporting frame being detachably connectable to a supporting fork of the carrier vehicle, which is pivotable about a first horizontal pivot axis oriented transversely to the longitudinal axis of the vehicle. The supporting frame comprises a first supporting assembly on which the at least one sweeping brush is rotatably mounted, and a second supporting assembly which is detachably connectable to the supporting fork, the first supporting assembly being connected to the second supporting assembly for pivotal movement about a second horizontal pivot axis and being detachably connectable to the carrier vehicle by at least one tension member. A sweeper having such a sweeping brush device is also proposed.

Abstract: The invention relates to an automotive sweeper with wheels for traveling along a ground surface and with at least one sweeping brush rotatingly drivable for sweeping the ground surface and with a dirt container adapted to be acted upon with a vacuum by a suction unit via a suction conduit and connected to a suction port via an intake line for the purpose of receiving sweepings. In order to develop the sweeper further in such a manner that it achieves an improved cleaning result with as little use of energy as possible it is suggested in accordance with the invention that the suction conduit be integrated into the dirt container at least in sections, wherein the outlet of the intake line opening into the dirt container is arranged next to at least one inlet area of the suction conduit.

Abstract: A method and a device for automatic detection of an equipment status of optional power consuming components, such as an air conditioning compressor, for an automobile are described. A signal formed in the automotive controller is monitored as a function of an engine load to determine whether the signal undergoes a certain change, for example, reaches a predetermined range, when an optional power consuming component is turned on, or power is demanded through corresponding switch operation, indicating the presence of the optional power consuming component, with the goal of achieving a permanent change in control data as a function of the automotive equipment present.

Abstract: A universal-joint tool head, having a tool platform which can move in three axes, at least three connecting rods which are articulatedly mounted on the tool platform and can be displaced independently of one another, at least three linear-movement drives, which are arranged around and at a distance from the tool platform and are parallel to one another, for the connecting rods articulatedly mounted thereon, the connecting rods being articulatedly mounted on the tool platform in such a manner that they can move on all sides and on the linear-movement drives in such a manner that they can pivot about pins running perpendicular to the direction of movement of the linear-movement drives.