Patents by Inventor Joachim Zettler

Joachim Zettler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Sustained release composition of prostacyclin
    Patent number: 9872864
    Abstract: The present invention relates to sustained release compositions of prostacyclin, as well as uses thereof, in particular for the prevention and/or treatment of pulmonary arterial hypertension.
    Type: Grant
    Filed: August 10, 2012
    Date of Patent: January 23, 2018
    Assignee: Ascendis Pharma A/S
    Inventors: Kennett Sprogøe, Harald Rau, Ulrich Hersel, Thomas Wegge, Oliver Keil, Joachim Zettler
  • Novel Polymeric hGH Prodrugs
    Publication number: 20170354716
    Abstract: The present invention relates to a polymeric human growth hormone prodrug and dry, liquid and reconstituted pharmaceutical formulations comprising said prodrug. It furthermore relates to their use as medicaments for the treatment of diseases which can be treated with growth hormone and to methods of treatment. It also relates to methods of application of such polymeric human growth hormone prodrug or pharmaceutical formulation.
    Type: Application
    Filed: November 17, 2015
    Publication date: December 14, 2017
    Applicant: Ascendis Pharma Endocrinology Division A/S
    Inventors: Thomas Kurpiers, Harald Rau, Evelyn Exner, Steen Jensen, Grethe Nørskov Rasmussen, Torben Lessmann, Thomas Wegge, Alina Hermann, Nina Schubert, Anna Splanemann, Joachim Zettler
  • Carrier-linked treprostinil prodrugs
    Patent number: 9561287
    Abstract: The present invention relates to prodrugs or a pharmaceutically acceptable salt thereof comprising a covalent treprostinil carrier conjugate as well as pharmaceutical composition comprising said compounds. The compounds may be used as medicaments, especially for diseases or disorders which can be treated by treprostinil, such as pulmonary arterial hypertension (PAH).
    Type: Grant
    Filed: August 10, 2012
    Date of Patent: February 7, 2017
    Assignee: Ascendis Pharma A/S
    Inventors: Ulrich Hersel, Harald Rau, Torben Lessmann, Nicola Bisek, Guillaume Maitro, Kennett Sprogøe, Thomas Wegge, Oliver Keil, Joachim Zettler
  • Relaxin Prodrugs
    Publication number: 20160296600
    Abstract: The present invention relates to a carrier-linked relaxin prodrug, pharmaceutical compositions comprising said prodrug, their use as medicaments for the treatment of diseases which can be treated with relaxin, methods of application of such carrier-linked relaxin prodrug or pharmaceutical compositions, methods of treatment, and containers comprising such prodrug or compositions.
    Type: Application
    Filed: November 10, 2014
    Publication date: October 13, 2016
    Applicant: Ascendis Pharma Relaxin Division A/S
    Inventors: Kennett Sprogøe, Felix Cleemann, Harald Rau, Nicole Hassepass, Thomas Wegge, Joachim Zettler, Ana Bernhard
  • Modified Hydrogels
    Publication number: 20160089446
    Abstract: The present invention relates to a process for the preparation of a hydrogel suitable as carrier in a hydrogel-linked prodrug, to hydrogels obtainable from said process, the use of such hydrogel as a carrier in a hydrogel-linked prodrug and to hydrogel-linked prodrugs comprising a covalently conjugated hydrogel of the present invention. The hydrogel prodrug carrier has a reduced drug loading on the outside of the hydrogel carrier. This is achieved by reducing the number of functional groups of the hydrogel, in particular those at its surface.
    Type: Application
    Filed: April 16, 2014
    Publication date: March 31, 2016
    Applicant: Ascendis Pharma A/S
    Inventors: Ulrich HERSEL, Harald RAU, Burkhardt LAUFER, Joachim ZETTLER, Romy REIMANN
  • Sustained Release Composition of Prostacyclin
    Publication number: 20140303245
    Abstract: The present invention relates to sustained release compositions of prostacyclin, as well as uses thereof, in particular for the prevention and/or treatment of pulmonary arterial hypertension.
    Type: Application
    Filed: August 10, 2012
    Publication date: October 9, 2014
    Applicant: Ascendis Pharma A/S
    Inventors: Kennett Sprogøe, Harald Rau, Ulrich Hersel, Thomas Wegge, Oliver Keil, Joachim Zettler
  • Carrier-Linked Treprostinil Prodrugs
    Publication number: 20140296150
    Abstract: The present invention relates to prodrugs or a pharmaceutically acceptable salt thereof comprising a covalent treprostinil carrier conjugate as well as pharmaceutical composition comprising said compounds. The compounds may be used as medicaments, especially for diseases or disorders which can be treated by treprostinil, such as pulmonary arterial hypertension (PAH).
    Type: Application
    Filed: August 10, 2012
    Publication date: October 2, 2014
    Applicant: Ascendis Pharma A/S
    Inventors: Ulrich Hersel, Harald Rau, Torben Lessmann, Nicola Bisek, Guillaume Maitro, Kennett Sprogøe, Thomas Wegge, Oliver Keil, Joachim Zettler