Abstract: The present disclosure generally relates to a molecular construct for multiphoton fluorescence microscopy imaging. The molecular construct has a first, non-fluorescent configuration (2PAP-C) and a second, fluorescent configuration (2PAP-CL), and comprises a two-photon absorbing probe (2PAP) linked to a photochromic molecule that can be reversibly changed from a first colored isomeric form (C) to a second colorless isomeric form (CL). The first colored form (C) can be isomerized to the second colorless isomeric form (CL) upon absorption of two photons by the two-photon absorbing probe (2PAP). The present disclosure also relates to a method for analyzing a target structure in a multiphoton microscope utilizing the molecular construct. Furthermore, the present disclosure relates to an antibody tagged with the molecular construct, and to the use of the molecular construct for imaging a target structure.

Abstract: The present disclosure generally relates to a molecular construct for multiphoton fluorescence microscopy imaging. The molecular construct has a first, non-fluorescent configuration (2PAP-C) and a second, fluorescent configuration (2PAP-CL), and comprises a two-photon absorbing probe (2PAP) linked to a photochromic molecule that can be reversibly changed from a first colored isomeric form (C) to a second colorless isomeric form (CL). The first colored form (C) can be isomerized to the second colorless isomeric form (CL) upon absorption of two photons by the two-photon absorbing probe (2PAP). The present disclosure also relates to a method for analyzing a target structure in a multiphoton microscope utilizing the molecular construct. Furthermore, the present disclosure relates to an antibody tagged with the molecular construct, and to the use of the molecular construct for imaging a target structure.

Abstract: A modular bag system has components for constructing a carrying bag of a variable, customized shape. The bag includes a main body and side gusset panels. The main body has edges provided with zippers. Two lateral edges are approximated to form a tube; at least part of the outer edge of each side gusset panel has a zipper for joining to the ends of the tube. The bag may also include a handle piece provided with a zipper for joining to the main body. The side gusset panels each have a round shape, a substantially square shape, an oblong shape, or a trapezoidal shape, for forming a duffel/gym bag, an overnight/weekender bag, a briefcase/portfolio, or a tote bag, respectively.

Abstract: A modular bag system has components for constructing a carrying bag of a variable, customized shape. The bag includes a main body and side gusset panels. The main body has edges provided with zippers. Two lateral edges are approximated to form a tube; at least part of the outer edge of each side gusset panel has a zipper for joining to the ends of the tube. The bag may also include a handle piece provided with a zipper for joining to the main body. The side gusset panels each have a round shape, a substantially square shape, an oblong shape, or a trapezoidal shape, for forming a duffel/gym bag, an overnight/weekender bag, a briefcase/portfolio, or a tote bag, respectively.

Abstract: A system and method for producing custom-designed objects. Design information is input to the system by a designer; an inquiry is input by a customer. Product information is presented to the customer relating to the inquiry; the product represents an embodiment of the design. The design may be iteratively modified in accordance with additional information input by the designer and/or product preferences input by the customer. After the customer places a product order, the product is delivered to the customer; the product may include components assemblable by the customer so that the customer obtains a customized product.