Abstract: A resilient squeeze bottle dispensing package including an internal flexible bag which is suitable for dispensing viscous product such as toothpaste, but which includes an air valve which will automatically permit pressure equilibration in the chamber formed between the flexible bag and the interior of the bottle in response to a decrease in the atmospheric pressure surrounding the package. Employing a valve which permits such automatic pressure equilibration avoids unwanted oozing of viscous product from the discharge orifice of the package when the atmospheric pressure surrounding the package decreases, e.g., as by airplane travel or by travelling from a first elevation to a second substantially higher elevation.

Abstract: Compositions for the transdermal delivery of buprenorphine comprising a safe and effective amount of buprenorphine in a carrier comprising:(a) a polar solvent material selected from the group consisting of C.sub.3 -C.sub.4 diols, C.sub.3 -C.sub.6 triols, and mixtures thereof; and(b) a polar lipid material selected from the group consisting of fatty alcohol esters, fatty acid esters, and mixtures thereof;wherein said polar solvent material and said polar lipid material are present in a weight ratio of solvent material:lipid material of from about 60:40 to about 99:1. Preferably, the polar solvent material is propylene glycol, and the polar lipid material is an ester of a C.sub.8 -C.sub.12 fatty alcohol or fatty acid. Particularly preferred polar lipid materials include methyl laurate and methyl caprylate. The ratio of polar solvent material to polar lipid material is preferably from about 90:10 to about 98:2.

Abstract: A pouched through the washer and dryer laundry additive product having at least one of its walls constructed of finely apertured polymeric film. In a particularly preferred embodiment, both pouch walls are constructed of finely apertured polymeric film to permit substantially full dissolution and discharge of the washer additive contained in the pouch during the washing cycle, yet retain substantially all of the dryer additive until the product is transferred into an automatic clothes dryer along with the laundered textiles. Pouched through the washer and dryer laundry additive products of the present invention deliver a significantly greater quantity of dryer additive material onto the textiles being tumble dried when contrasted with comparably constructed pouches comprised entirely of nonwoven and/or paper material.