Patents by Inventor Joan D. Combie

Joan D. Combie has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Detection of morphine and its analogues using enzymatic hydrolysis
    Patent number: 4473640
    Abstract: The invention relates to a method for hydrolyzing drug-glucuronic acid conjugates present in mammalian body fluids, the conjugates being derived from a narcotic analgesic, antagonist, or agonist-antagonist whose metabolism includes conjugation with glucuronic acid. The method comprises incubating the body fluid sample at from about 60.degree. to about 70.degree. C., for at least about 1 hour, with .beta.-glucuronidase derived from Patella vulgata, and substantially increases the sensitivity of chromatographic techniques for the detection of morphine and its analogues.
    Type: Grant
    Filed: June 3, 1982
    Date of Patent: September 25, 1984
    Inventors: Joan D. Combie, Jerry W. Blake, Thomas E. Nugent, Thomas Tobin