Patents by Inventor Joan E. DURBIN

Joan E. DURBIN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Recombinant Newcastle disease viruses and uses thereof for the prevention of RSV disease or human metapneumovirus disease
    Patent number: 12391957
    Abstract: Described herein are recombinant Newcastle disease viruses (“NDVs”) comprising a packaged genome, wherein the packaged genome comprises a transgene encoding a respiratory syncytial virus (“RSV”) F protein or human metapneumovirus (“hMPV”) F protein. Also described herein are recombinant NDVs comprising a packaged genome, wherein the packaged genome comprises a transgene encoding a chimeric F protein, wherein the chimeric F protein comprises (i) an RSV F protein ectodomain and NDV F protein transmembrane and cytoplasmic domains; or (ii) an hMPV F protein ectodomain and NDV F protein transmembrane and cytoplasmic domains. The recombinant NDVs and compositions thereof are useful for the immunizing against RSV or hMPV as well as the prevention of RSV disease or hMPV disease.
    Type: Grant
    Filed: August 16, 2019
    Date of Patent: August 19, 2025
    Assignees: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Joan E. Durbin, Russell K. Durbin, Adolfo Garcia-Sastre, Ignacio Mena, Peter Palese
  • RECOMBINANT NEWCASTLE DISEASE VIRUSES AND USES THEREOF FOR THE PREVENTION OF RSV DISEASE OR HUMAN METAPNEUMOVIRUS DISEASE
    Publication number: 20210198323
    Abstract: Described herein are recombinant Newcastle disease viruses (“NDVs”) comprising a packaged genome, wherein the packaged genome comprises a transgene encoding a respiratory syncytial virus (“RSV”) F protein or human metapneumovirus (“hMPV”) F protein. Also described herein are recombinant NDVs comprising a packaged genome, wherein the packaged genome comprises a transgene encoding a chimeric F protein, wherein the chimeric F protein comprises (i) an RSV F protein ectodomain and NDV F protein transmembrane and cytoplasmic domains; or (ii) an hMPV F protein ectodomain and NDV F protein transmembrane and cytoplasmic domains. The recombinant NDVs and compositions thereof are useful for the immunizing against RSV or hMPV as well as the prevention of RSV disease or hMPV disease.
    Type: Application
    Filed: August 16, 2019
    Publication date: July 1, 2021
    Applicants: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Joan E. DURBIN, Russell K. DURBIN, Adolfo GARCIA-SASTRE, Ignacio MENA, Peter PALESE