Patents by Inventor Joan Elizabeth Smallshaw

Joan Elizabeth Smallshaw has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods for modifying toxic effects of proteinaceous compounds
    Patent number: 7829668
    Abstract: The present invention provides methods to produce immunotoxins (ITs) and cytokines with a reduced ability to promote vascular leak syndrome (VLS). The invention also provides ITs and cytokines which have been mutated to lack amino acid sequences which induce VLS. Also disclosed are methods for producing peptides that inhibit the induction of VLS by ITs and cytokines. Also disclosed are peptides comprising the (x)D(y) sequence to promote the extravasation of other molecules. Toxins mutated in the (x)D(y) motif or active site residues are disclosed for used in vaccines.
    Type: Grant
    Filed: May 19, 2003
    Date of Patent: November 9, 2010
    Assignee: Board of Regents, The University of Texas System
    Inventors: Ellen S. Vitetta, Victor F. Ghetie, Joan Elizabeth Smallshaw, Roxana G. Baluna
  • Compositions and methods for modifying toxic effects of proteinaceous compounds
    Publication number: 20040009148
    Abstract: The present invention provides methods to produce immunotoxins (ITs) and cytokines with a reduced ability to promote vascular leak syndrome (VLS). The invention also provides ITs and cytokines which have been mutated to lack amino acid sequences which induce VLS. Also disclosed are methods for producing peptides that inhibit the induction of VLS by ITs and cytokines. Also disclosed are peptides comprising the (x)D(y) sequence to promote the extravasation of other molecules. Toxins mutated in the (x)D(y) motif or active site residues are disclosed for used in vaccines.
    Type: Application
    Filed: May 19, 2003
    Publication date: January 15, 2004
    Inventors: Ellen S. Vitetta, Victor F. Ghetie, Joan Elizabeth Smallshaw, Roxana G. Baluna