Patents by Inventor Joan Haab
Joan Haab has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9938571Abstract: Manufacturing methods and compositions are described for production of self-contained microfluidic cartridge devices with on-board reagents for molecular biological testing. Sensitive reagents are stored in dry form without lyophilization or freezing, and reconstituted at the point of use with either a biological sample or a sample eluate at the point of use. Manufacturing methods include sheet and roll fabrication processes where the reagents are printed in place and sealed within individual microfluidic cartridges before gel vitrification.Type: GrantFiled: November 26, 2014Date of Patent: April 10, 2018Assignee: Micronics, Inc.Inventors: C. Frederick Battrell, Denise Maxine Hoekstra, Joan Haab, John R. Williford, Sabrina N. Gunderson, Elizabeth R. Leber, Isaac Sprague
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Publication number: 20150152481Abstract: Manufacturing methods and compositions are described for production of self-contained microfluidic cartridge devices with on-board reagents for molecular biological testing. Sensitive reagents are stored in dry form without lyophilization or freezing, and reconstituted at the point of use with either a biological sample or a sample eluate at the point of use. Manufacturing methods include sheet and roll fabrication processes where the reagents are printed in place and sealed within individual microfluidic cartridges before gel vitrification.Type: ApplicationFiled: November 26, 2014Publication date: June 4, 2015Inventors: C. Frederick Battrell, Denise Maxine Hoekstra, Joan Haab, John R. Williford, Sabrina N. Gates, Elizabeth R. Leber, Isaac Sprague
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Patent number: 8921085Abstract: Manufacturing methods and compositions are described for production of self-contained microfluidic cartridge devices with on-board reagents for molecular biological testing. Sensitive reagents are stored in dry form without lyophilization or freezing, and reconstituted at the point of use with either a biological sample or a sample eluate at the point of use. Manufacturing methods include sheet and roll fabrication processes where the reagents are printed in place and sealed within individual microfluidic cartridges before gel vitrification.Type: GrantFiled: December 12, 2011Date of Patent: December 30, 2014Assignee: Micronics, Inc.Inventors: C. Frederick Battrell, Denise Maxine Hoekstra, Joan Haab, John R. Williford, Sabrina N. Gates, Elizabeth R. Leber, Isaac Sprague
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Patent number: 8835146Abstract: Formulations for dry storage of PCR reagents are described. These formulations find use in manufacture of self-contained microfluidic card devices for PCR clinical testing in which the reagents are reconstituted at the point of testing. In these cards, TAQ polymerase is stored “on-board” in vitrified dry form without lyophilization or freezing, and is reconstituted by either the sample or a sample eluate during the assay.Type: GrantFiled: December 12, 2011Date of Patent: September 16, 2014Assignee: Micronics, Inc.Inventors: C. Frederick Battrell, Denise Maxine Hoekstra, Joan Haab, John R. Williford
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Patent number: 8747779Abstract: A microfluidic cartridge including on-board dry reagents and microfluidic circuitry for determining a clinical analyte or analytes from a few microliters of liquid sample; with docking interface for use in a host workstation, the workstation including a pneumatic fluid controller and spectrophotometer for monitoring analytical reactions in the cartridge.Type: GrantFiled: October 13, 2011Date of Patent: June 10, 2014Assignee: Micronics, Inc.Inventors: Isaac Sprague, John E. Emswiler, C. Frederick Battrell, Joan Haab, Sean M. Pennell, Justin L. Kay, Zane B. Miller, Troy D. Daiber
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Publication number: 20120271127Abstract: Biohazard specimen collection containers are provided with an external disposable skin, that is stripped away and discarded after the biohazardous specimen is collected, thus reducing or eliminating objectionable or dangerous residues on the outside surfaces of the container. Further, we teach that the sample collection container with external disposable skin may also serve as an integrated microfluidic biosample processing and analytical device, thereby providing a single entry, disposable assay unit, kit and system for “world-to-result” clinical diagnostic testing. These integrated assay devices are provided with synergic, multiple safe-handling features for protecting healthcare workers who handle them. The modified collection containers and analytical devices find application, for example, in PCR detection of infectious organisms or pathogenic markers collected on a swab.Type: ApplicationFiled: June 7, 2012Publication date: October 25, 2012Applicant: Micronics, Inc.Inventors: C. Frederick Battrell, Jason Capodanno, John Clemmens, Joan Haab, John Gerdes
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Patent number: 8216832Abstract: Biohazard specimen collection containers are provided with an external disposable skin, that is stripped away and discarded after the biohazardous specimen is collected, thus reducing or eliminating objectionable or dangerous residues on the outside surfaces of the container. Further, we teach that the sample collection container with external disposable skin may also serve as an integrated microfluidic biosample processing and analytical device, thereby providing a single entry, disposable assay unit, kit and system for “world-to-result” clinical diagnostic testing. These integrated assay devices are provided with synergic, multiple safe-handling features for protecting healthcare workers who handle them. The modified collection containers and analytical devices find application, for example, in PCR detection of infectious organisms or pathogenic markers collected on a swab.Type: GrantFiled: January 28, 2010Date of Patent: July 10, 2012Assignee: Micronics, Inc.Inventors: C. Frederick Battrell, Jason Capodanno, John Clemmens, Joan Haab, John Gerdes
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Publication number: 20120156112Abstract: A microfluidic cartridge including on-board dry reagents and microfluidic circuitry for determining a clinical analyte or analytes from a few microliters of liquid sample; with docking interface for use in a host workstation, the workstation including a pneumatic fluid controller and spectrophotometer for monitoring analytical reactions in the cartridge.Type: ApplicationFiled: October 13, 2011Publication date: June 21, 2012Applicant: Micronics, Inc.Inventors: Isaac Sprague, John E. Emswiler, C. Frederick Battrell, Joan Haab, Sean M. Pennell, Justin L. Kay, Zane B. Miller, Troy D. Daiber
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Publication number: 20120156750Abstract: Manufacturing methods and compositions are described for production of self-contained microfluidic cartridge devices with on-board reagents for molecular biological testing. Sensitive reagents are stored in dry form without lyophilization or freezing, and reconstituted at the point of use with either a biological sample or a sample eluate at the point of use. Manufacturing methods include sheet and roll fabrication processes where the reagents are printed in place and sealed within individual microfluidic cartridges before gel vitrification.Type: ApplicationFiled: December 12, 2011Publication date: June 21, 2012Applicant: Micronics, Inc.Inventors: C. Frederick Battrell, Denise Maxine Hoekstra, Joan Haab, John R. Williford, Sabrina N. Gates, Elizabeth R. Leber, Isaac Sprague
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Publication number: 20120142070Abstract: Formulations for dry storage of PCR reagents are described. These formulations find use in manufacture of self-contained microfluidic card devices for PCR clinical testing in which the reagents are reconstituted at the point of testing. In these cards, TAQ polymerase is stored “on-board” in vitrified dry form without lyophilization or freezing, and is reconstituted by either the sample or a sample eluate during the assay.Type: ApplicationFiled: December 12, 2011Publication date: June 7, 2012Applicant: Micronics, Inc.Inventors: C. Frederick Battrell, Denise Maxine Hoekstra, Joan Haab, John R. Williford
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Publication number: 20100274155Abstract: Biohazard specimen collection containers are provided with an external disposable skin, that is stripped away and discarded after the biohazardous specimen is collected, thus reducing or eliminating objectionable or dangerous residues on the outside surfaces of the container. Further, we teach that the sample collection container with external disposable skin may also serve as an integrated microfluidic biosample processing and analytical device, thereby providing a single entry, disposable assay unit, kit and system for “world-to-result” clinical diagnostic testing. These integrated assay devices are provided with synergic, multiple safe-handling features for protecting healthcare workers who handle them. The modified collection containers and analytical devices find application, for example, in PCR detection of infectious organisms or pathogenic markers collected on a swab.Type: ApplicationFiled: January 28, 2010Publication date: October 28, 2010Applicant: Micronics, Inc.Inventors: C. Frederick Battrell, Jason Capodanno, John Clemmens, Joan Haab, John Gerdes
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Publication number: 20090325276Abstract: Combinations of microfluidic diagnostic testing modules for simultaneous evaluations of serological and molecular biological targets are provided, and include panel testing for both antibodies (or antigens) and nucleic acid targets in one single-use device. These improvements are directed to evaluating the overall progress and activity of a pathogenic process in real time, at the point of care, not merely the presence or absence of a particular diagnostic marker, which can often be incomplete or misleading.Type: ApplicationFiled: March 25, 2009Publication date: December 31, 2009Applicant: Micronics, Inc.Inventors: C. Frederick Battrell, John Gerdes, Wayne L. Breidford, Jason Capodanno, Stephen Mordue, John Clemmens, Denise Maxine Hoekstra, Christy A. Lancaster, John R. Williford, Patrick Maloney, Joan Haab