Abstract: This invention provides for a method of synergistically reducing viral load in a patient infected with a virus. The method comprises the oral co-administering an amount of thiophosphonoformic acid and an amount of a nucleoside or nucleotide reverse transcriptase inhibitor in a synergistic combination.

Abstract: The present invention provides compositions and methods for inhibiting the replication of influenza virus by administering thiophosphonoformic acid alone or in combination with a neuraminidase inhibitor, for example, oseltamivir.

Abstract: The present invention provides novel uses and compositions for 5,10-methylene tetrahydrofolate (“5,10-CH2-THFA”) in the treatment of cancer. The present invention is based on the surprising result that 5,10-CH2-THFA, while increasing the efficacy of 5-fluoruracil (5-FU) in reducing the rate of tumor growth and increasing survivorship, also reduces the toxicity to the patient of 5-FU. The present invention provides methods and compositions for treating cancer patients that include 5-FU, 5,10-CH2-THFA, and one or more additional anticancer drugs. Such methods and compositions can provide increased efficacy and reduced toxicity when compared with current treatment modalities.

Abstract: As an effective therapy for proliferative skin and eye diseases such as psoriasis and proliferative diabetic retinopathy, this invention provides ribozymes and ribozyme delivery systems which cleave RNA encoding cytokines involved in inflammation, matrix metalloproteinases, a cyclin, a cell-cycle dependent kinase, a growth factor, or a reductase.

Abstract: The present invention provides an apparatus for the purification of Adeno-associated virus (AAV) and methods of use including an anion exchange filter unit and a cation exchange capture unit. At one end, the cation exchange capture unit reversibly engages the anion exchange filter unit and when engaged is in fluid communication. The cation exchange capture unit may, at the opposing end, reversibly engage a syringe or apparatus able to provide negative pressure to draw a fluid containing AAV through the anion exchange filter unit then cation exchange capture unit where the AAV is captured. The anion exchange filter unit is disengaged and the purified AAV is eluted from the cation exchange capture unit.

Abstract: The present invention provides genes, nucleic acid sequences, proteins and amino acid sequences that are, involved in the inhibition of apoptosis induction in cells. The invention also provides the RNA correlates of these genes and nucleic acid sequences. Further provided are isolated nucleic acid molecules that interact with the genes, nucleic acid sequences and RNA correlates disclosed herein, such that their inhibitory effect on apoptosis induction is lessened and, therefore, apoptosis induction is facilitated.

Abstract: The subject matter of the present invention relates to aminoalkylcarbamates of forskolin and the methods of using these compounds. Specifically, the aminoalkylcarbamates may be utilized in the synthesis of forskolin derivatives. The final derivatives may, in turn, be used in the development of in vivo and in vitro assays designed to study different proteins.