Patents by Inventor Joan Smallshaw

Joan Smallshaw has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods for modifying toxic effects of proteinaceous compounds
    Publication number: 20060100135
    Abstract: The present invention provides methods to produce immunotoxins (ITs) and cytokines with a reduced ability to promote vascular leak syndrome (VLS). The invention also provides ITs and cytokines which have been mutated to lack amino acid sequences which induce VLS.
    Type: Application
    Filed: October 31, 2005
    Publication date: May 11, 2006
    Inventors: Ellen Vitetta, Victor Ghetie, Joan Smallshaw, Roxana Baluna
  • Compositions and methods for modifying toxic effects of proteinaceous compounds
    Patent number: 6566500
    Abstract: The present invention provides methods to produce immunotoxins (ITs) and cytokines with a reduced ability to promote vascular leak syndrome (VLS). The invention also provides ITs and cytokines which have been mutated to lack amino acid sequences which induce VLS. Also disclosed are methods for producing peptides that inhibit the induction of VLS by ITs and cytokines. Also disclosed are peptides comprising the (x)D(y) sequence to promote the extravasation of other molecules. Toxins mutated in the (x)D(y) motif or active site residues are disclosed for used in vaccines.
    Type: Grant
    Filed: March 30, 2000
    Date of Patent: May 20, 2003
    Assignee: Board of Regents, The University of Texas System
    Inventors: Ellen S. Vitetta, Victor F. Ghetie, Joan Smallshaw, Roxana G. Baluna