Patents by Inventor Joana M. MURAD

Joana M. MURAD has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CHIMERIC ANTIGEN RECEPTORS TARGETING TIM-1
    Publication number: 20230355673
    Abstract: The invention provides chimeric antigen receptors (CARs) that specifically bind to the T-cell immunoglobulin and mucin domain 1 (TIM-1) protein. The invention further relates to modified immune cells, e.g., T or NK cells, comprising such CARs, CAR-encoding nucleic acids, CAR-encoding vectors, and methods of making such compositions. The invention further relates to methods for therapeutic use of these CARs and modified immune cells for the treatment of a condition, disorder, or disease associated with cells expressing TIM-1 (e.g., cancer).
    Type: Application
    Filed: December 12, 2022
    Publication date: November 9, 2023
    Inventors: Terrance A. STADHEIM, Joana M. MURAD, Jake REDER, Henry C. MARSH, Li-Zhen HE, Tibor KELER
  • Chimeric antigen receptors targeting TIM-1
    Patent number: 11541076
    Abstract: The invention provides chimeric antigen receptors (CARs) that specifically bind to the T-cell immunoglobulin and mucin domain 1 (TIM-1) protein. The invention further relates to modified immune cells, e.g., T or NK cells, comprising such CARs, CAR-encoding nucleic acids, CAR-encoding vectors, and methods of making such compositions. The invention further relates to methods for therapeutic use of these CARs and modified immune cells for the treatment of a condition, disorder, or disease associated with cells expressing TIM-1 (e.g., cancer).
    Type: Grant
    Filed: January 12, 2018
    Date of Patent: January 3, 2023
    Assignees: CELDARA MEDICAL, LLC, CELLDEX THERAPEUTICS, INC.
    Inventors: Terrance A. Stadheim, Joana M. Murad, Jake Reder, Henry C. Marsh, Jr., Li-Zhen He, Tibor Keler
  • CHIMERIC ANTIGEN RECEPTORS TARGETING TIM-1
    Publication number: 20190336534
    Abstract: The invention provides chimeric antigen receptors (CARs) that specifically bind to the T-cell immunoglobulin and mucin domain 1 (TIM-1) protein. The invention further relates to modified immune cells, e.g., T or NK cells, comprising such CARs, CAR-encoding nucleic acids, CAR-encoding vectors, and methods of making such compositions. The invention further relates to methods for therapeutic use of these CARs and modified immune cells for the treatment of a condition, disorder, or disease associated with cells expressing TIM-1 (e.g., cancer).
    Type: Application
    Filed: January 12, 2018
    Publication date: November 7, 2019
    Inventors: Terrance A. STADHEIM, Joana M. MURAD, Jake REDER, Henry C. MARSH, JR., Li-Zhen HE, Tibor KELER