Abstract: Simultaneous inhibition of the aryl hydrocarbon receptor (AhR) and SRC abolishing androgen receptor (AR) signaling in prostate cancer cells is disclosed herein as an effective treatment for prostate cancer. Provided herein is a therapeutic composition that comprises an aryl hydrocarbon receptor (AhR) antagonist and an SRC inhibitor. In one embodiment, the therapeutic composition further comprises a pharmaceutical excipient. In one embodiment, the AhR antagonist is CH223191 and the SRC inhibitor is PP2 and the therapeutic composition further comprises a pharmaceutical excipient. Methods of using the therapeutic composition to treat prostate cancer or to inhibit prostate cancer cells are also disclosed.

Abstract: Simultaneous inhibition of the aryl hydrocarbon receptor (AhR) and SRC abolishing androgen receptor (AR) signaling in prostate cancer cells is disclosed herein as an effective treatment for prostate cancer. Provided herein is a therapeutic composition that comprises an aryl hydrocarbon receptor (AhR) antagonist and an SRC inhibitor. In one embodiment, the therapeutic composition further comprises a pharmaceutical excipient. In one embodiment, the AhR antagonist is CH223191 and the SRC inhibitor is PP2 and the therapeutic composition further comprises a pharmaceutical excipient. Methods of using the therapeutic composition to treat prostate cancer or to inhibit prostate cancer cells are also disclosed.

Abstract: Simultaneous inhibition of the aryl hydrocarbon receptor (AhR) and SRC abolishing androgen receptor (AR) signaling in prostate cancer cells is disclosed herein as an effective treatment for prostate cancer. Provided herein is a therapeutic composition that comprises an aryl hydrocarbon receptor (AhR) antagonist and an SRC inhibitor. In one embodiment, the therapeutic composition further comprises a pharmaceutical excipient. In one embodiment, the AhR antagonist is CH223191 and the SRC inhibitor is PP2 and the therapeutic composition further comprises a pharmaceutical excipient. Methods of using the therapeutic composition to treat prostate cancer or to inhibit prostate cancer cells are also disclosed.

Abstract: A method of evaluating and measuring the smell of urine is disclosed. The method includes collecting urine samples from at least two donors and pooling the samples together into a combined sample. At least about 99% of the microbes are then removed from the combined sample to obtain a microbe-free sample. The microbe-free sample is then inoculated with at least two known microbes. The method also includes introducing the inoculated sample into a material or product and allowing the microbes to grow and emit malodors. The material or product is then evaluated for malodors that smell like urine to establish an odor intensity level. The method further includes recording the odor intensity level and scoring the odor intensity level.

Abstract: The present inventions relate to novel skin protectant creams and the use of such creams to cleanse, treat, and protect skin. The skin protectant creams can be topically applied to protect skin from irritants, to block the action of irritants such as enzymes, and to treat skin that has been subject to irritants. The creams can be applied manually or incorporated into disposable applicators, such as wipers or swabs. The skin protectant creams of the present invention are particularly useful in the prevention of severe skin breakdown which can lead to partial thickness skin wounds.

Abstract: The present invention relates to disposable absorbent articles comprising skin health and odor control additives for the treatment and prevention of skin irritation. The skin health treatment additive comprises an oil soluble wax that forms a tight lattice to protect the skin, and vitamins, lipids and triglycerides to protect and replenish the skin. Such disposable absorbent articles of the present invention are especially advantageous for the treatment and skin breakdown leading to partial full thickness wounds or pressure ulcers.

Abstract: The present invention relates to disposable absorbent wound dressings comprising skin health treatment additives for the treatment and prevention of Stage I-IV partial and full thickness pressure wounds. The disposable dressings conform to the anatomical shape of the body of a human and are capable of absorbing large quantities of wound drainage or exudates. Such disposable dressings are low-adherent and facilitate painless removal without disturbing a healing tissue bed. Such disposable wound dressings of the present invention are especially advantageous for the treatment of Stage I-IV pressure ulcers located in the sacral/coccyx area of the spine.

Abstract: A paper product that is applied with a lotion composition is provided. In one embodiment of the present invention, the lotion composition includes water in an amount up to about 90% by weight of the lotion, an emollient component in an amount up to about 20% by weight of the lotion, a fatty alcohol component in an amount up to about 50% by weight of the lotion, an emulsifier component in an amount up to about 40% by weight of the lotion, and a skin conditioning component in an amount up to about 60% by weight of the lotion. Typically, the add-on level of the lotion composition is between about 1% to about 15% by weight of the paper product. As a result, the paper product can be used to dry the hands of a user, while also imparting certain benefits to the skin as well.

Abstract: The present inventions relate to novel skin protectant creams and the use of such creams to cleanse, treat, and protect skin. The skin protectant creams can be topically applied to protect skin from irritants, to block the action of irritants such as enzymes, and to treat skin that has been subject to irritants. The creams can be applied manually or incorporated into disposable applicators, such as wipers or swabs. The skin protectant creams of the present invention are particularly useful in the prevention of severe skin breakdown which can lead to partial thickness skin wounds.

Abstract: The present invention relates to disposable absorbent wound dressings comprising skin health treatment additives for the treatment and prevention of Stage I-IV partial and full thickness pressure wounds. The disposable dressings conform to the anatomical shape of the body of a human and are capable of absorbing large quantities of wound drainage or exudates. Such disposable dressings are low-adherent and facilitate painless removal without disturbing a healing tissue bed. Such disposable wound dressings of the present invention are especially advantageous for the treatment of Stage I-IV pressure ulcers located in the sacral/coccyx area of the spine.

Abstract: The present invention relates to disposable absorbent articles comprising skin health and odor control additives for the treatment and prevention of skin irritation. The skin health treatment additive comprises an oil soluble wax that forms a tight lattice to protect the skin, and vitamins, lipids and triglycerides to protect and replenish the skin. Such disposable absorbent articles of the present invention are especially advantageous for the treatment of skin breakdown leading to partial full thickness wounds or pressure ulcers.