Patents by Inventor Joann Hux

Joann Hux has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR SEQUENTIAL STACKING OF NUCLEIC ACID SEQUENCES INTO A GENOMIC LOCUS
    Publication number: 20230172985
    Abstract: The present invention encompasses compositions and methods for the sequential stacking of donor nucleic acids into a single genomic locus within a cell to allow for the introduction of relatively long nucleic sequences. This allows for insertion into the genome of a donor nucleic acid sequence that exceeds the packaging capacity of a single adeno-associated viral vector.
    Type: Application
    Filed: September 16, 2022
    Publication date: June 8, 2023
    Applicant: PRECISION BIOSCIENCES, INC.
    Inventors: JOANN HUX, JAMES JEFFERSON SMITH
  • COMPOSITIONS AND METHODS FOR SEQUENTIAL STACKING OF NUCLEIC ACID SEQUENCES INTO A GENOMIC LOCUS
    Publication number: 20220273715
    Abstract: The present invention encompasses compositions and methods for the sequential stacking of donor nucleic acids into a single genomic locus within a cell to allow for the introduction of relatively long nucleic sequences. This allows for insertion into the genome of a donor nucleic acid sequence that exceeds the packaging capacity of a single adeno-associated viral vector.
    Type: Application
    Filed: July 24, 2020
    Publication date: September 1, 2022
    Applicant: Precision BioSciences, Inc.
    Inventors: Joann Hux, James Jefferson Smith
  • NUCLEIC ACID MOLECULES ENCODING AN ENGINEERED ANTIGEN RECEPTOR AND AN INHIBITORY NUCLEIC ACID MOLECULE AND METHODS OF USE THEREOF
    Publication number: 20220228115
    Abstract: The present disclosure provides nucleic acid molecules encoding an engineered antigen receptor, such as a chimeric antigen receptor or exogenous T cell receptor, and an inhibitory nucleic acid molecule, such as an RNA interference molecule. The present disclosure further relates to nucleic acids, DNA constructs, vectors, pharmaceutical compositions, genetically-modified cells, and methods of treatment that utilize the nucleic acid molecules of the invention.
    Type: Application
    Filed: April 4, 2022
    Publication date: July 21, 2022
    Applicant: Precision Biosciences, Inc.
    Inventors: Joann Hux, Aaron Martin, Derek Jantz, Clayton Beard
  • NUCLEIC ACID MOLECULES ENCODING AN ENGINEERED ANTIGEN RECEPTOR AND AN INHIBITORY NUCLEIC ACID MOLECULE AND METHODS OF USE THEREOF
    Publication number: 20200339952
    Abstract: The present disclosure provides nucleic acid molecules encoding an engineered antigen receptor, such as a chimeric antigen receptor or exogenous T cell receptor, and an inhibitory nucleic acid molecule, such as an RNA interference molecule. The present disclosure further relates to nucleic acids, DNA constructs, vectors, pharmaceutical compositions, genetically-modified cells, and methods of treatment that utilize the nucleic acid molecules of the invention.
    Type: Application
    Filed: July 13, 2020
    Publication date: October 29, 2020
    Applicant: Precision Biosciences, Inc.
    Inventors: Joann Hux, Aaron Martin, Derek Jantz, Clayton Beard
  • Nucleic acid molecules encoding an engineered antigen receptor and an inhibitory nucleic acid molecule and methods of use thereof
    Patent number: 10745665
    Abstract: The present disclosure provides nucleic acid molecules encoding an engineered antigen receptor, such as a chimeric antigen receptor or exogenous T cell receptor, and an inhibitory nucleic acid molecule, such as an RNA interference molecule. The present disclosure further relates to nucleic acids, DNA constructs, vectors, pharmaceutical compositions, genetically-modified cells, and methods of treatment that utilize the nucleic acid molecules of the invention.
    Type: Grant
    Filed: November 8, 2019
    Date of Patent: August 18, 2020
    Assignee: Precision BioSciences, Inc.
    Inventors: Joann Hux, Aaron Martin, Derek Jantz, Clayton Beard
  • NUCLEIC ACID MOLECULES ENCODING AN ENGINEERED ANTIGEN RECEPTOR AND AN INHIBITORY NUCLEIC ACID MOLECULE AND METHODS OF USE THEREOF
    Publication number: 20200063102
    Abstract: The present disclosure provides nucleic acid molecules encoding an engineered antigen receptor, such as a chimeric antigen receptor or exogenous T cell receptor, and an inhibitory nucleic acid molecule, such as an RNA interference molecule. The present disclosure further relates to nucleic acids, DNA constructs, vectors, pharmaceutical compositions, genetically-modified cells, and methods of treatment that utilize the nucleic acid molecules of the invention.
    Type: Application
    Filed: November 8, 2019
    Publication date: February 27, 2020
    Applicant: Precision Biosciences, Inc.
    Inventors: Joann Hux, Aaron Martin, Derek Jantz, Clayton Beard