Patents by Inventor JoAnn Suzich
JoAnn Suzich has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9499590Abstract: The present invention relates to novel respiratory syncytial virus (RSV) F peptides and compositions comprising them. The present invention also relates to methods of evaluating anti-RSV antibody binding to F peptides. The present invention also relates to antibodies that immunospecifically bind to an F peptide of the present invention. The invention further provides methods and protocols for the administration of F peptides and/or antibodies that immunospecifically bind to F peptides for the prevention, neutralization, treatment of RSV infection. Additionally, the methods of the invention may be useful for the treatment, prevention and the amelioration of symptoms associated with RSV infection.Type: GrantFiled: September 8, 2014Date of Patent: November 22, 2016Assignee: MedImmune, LLCInventors: Josephine McAuliffe, Frances Palmer-Hill, Qing Zhu, JoAnn Suzich
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Publication number: 20150125479Abstract: The present invention relates to novel respiratory syncytial virus (RSV) F peptides and compositions comprising them. The present invention also relates to methods of evaluating anti-RSV antibody binding to F peptides. The present invention also relates to antibodies that immunospecifically bind to an F peptide of the present invention. The invention further provides methods and protocols for the administration of F peptides and/or antibodies that immunospecifically bind to F peptides for the prevention, neutralization, treatment of RSV infection. Additionally, the methods of the invention may be useful for the treatment, prevention and the amelioration of symptoms associated with RSV infection.Type: ApplicationFiled: September 8, 2014Publication date: May 7, 2015Applicant: MEDIMMUNE, LLCInventors: Josephine McAuliffe, Frances Palmer-Hill, Qing Zhu, JoAnn Suzich
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Patent number: 8852608Abstract: The present invention relates to novel respiratory syncytial virus (RSV) F peptides and compositions comprising them. The present invention also relates to methods of evaluating anti-RSV antibody binding to F peptides. The present invention also relates to antibodies that immunospecifically bind to an F peptide of the present invention. The invention further provides methods and protocols for the administration of F peptides and/or antibodies that immunospecifically bind to F peptides for the prevention, neutralization, treatment of RSV infection. Additionally, the methods of the invention may be useful for the treatment, prevention and the amelioration of symptoms associated with RSV infection.Type: GrantFiled: December 23, 2009Date of Patent: October 7, 2014Assignee: MedImmune, LLCInventors: Josephine McAuliffe, Frances Palmer-Hill, Qing Zhu, Joann Suzich
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Publication number: 20120263715Abstract: The present invention provides methods for preventing, managing, treating and/or ameliorating a respiratory syncytial virus (RSV) infection (e.g., acute RSV disease, or a RSV upper respiratory tract infection (URI) and/or lower respiratory tract infection (LRI)), and/or a symptom or a long-term respiratory condition relating thereto (e.g., asthma, wheezing, reactive airway disease (RAD), or chronic obstructive pulmonary disease (COPD)) in a human subject, comprising topically administering to said human an effective amount of one or more antibodies that immunospecifically bind to one or more RSV antigens with a high affinity and/or high avidity and further comprise a modified IgG constant domain, or FcRn-binding fragment thereof, to not only decrease RSV infection, but also decrease the pro-inflammatory epithelial cell immune responses in order to mitigate the later development of asthma and/or wheezing and/or COPD in said patient.Type: ApplicationFiled: October 28, 2010Publication date: October 18, 2012Applicant: MEDIMMUNE, LLCInventors: Bettina Richter, JoAnn Suzich
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Publication number: 20120156235Abstract: The present invention relates to novel respiratory syncytial virus (RSV) F peptides and compositions comprising them. The present invention also relates to methods of evaluating anti-RSV antibody binding to F peptides. The present invention also relates to antibodies that immunospecifically bind to an F peptide of the present invention. The invention further provides methods and protocols for the administration of F peptides and/or antibodies that immunospecifically bind to F peptides for the prevention, neutralization, treatment of RSV infection. Additionally, the methods of the invention may be useful for the treatment, prevention and the amelioration of symptoms associated with RSV infection.Type: ApplicationFiled: December 23, 2009Publication date: June 21, 2012Applicant: MEDIMMUNE, LLC.Inventors: Josephine McAuliffe, Frances Palmer-Hill, Qing Zhu, Joann Suzich
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Publication number: 20110008329Abstract: The present invention provides methods for managing, treating and/or ameliorating a respiratory syncytial virus (RSV) infection (e.g., acute RSV disease, or a RSV upper respiratory tract infection (URI) and/or lower respiratory tract infection (LRI)), and/or a symptom or a long-term respiratory condition relating thereto (e.g., asthma, wheezing, reactive airway disease (RAD), or chronic obstructive pulmonary disease (COPD)) in a subject, comprising administering to said human an effective amount of one or more antibodies that immunospecifically bind to one or more RSV antigens with a high affinity and/or high avidity and further comprise a modified IgG constant domain, or FcRn-binding fragment thereof, to not only decrease RSV infection, but also decrease the pro-inflammatory epithelial cell immune responses in order to mitigate the later development of asthma and/or wheezing and/or COPD in said patient.Type: ApplicationFiled: June 25, 2008Publication date: January 13, 2011Applicant: Medlmmune, LLCInventors: Subramaniam Krishnan, JoAnn Suzich, Peter Kiener, Genevieve Losonsky, Herren Wu, William Dall'Acqua, Bettina Richter
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Publication number: 20100239585Abstract: The present invention provides antibodies that immunospecifically bind to a polypeptide of a mammalian metapneumovirus, compositions comprising said antibodies, and methods for producing such antibodies. In particular, the invention provides monoclonal antibodies that immunospecifically bind to the F protein of human metapneumovirus and that neutralize human metapneumovirus. The invention also provides antibodies that cross-react with both the F protein of a mammalian metapneumovirus and the F protein of a mammalian respiratory syncytial virus and that neutralize both viruses. Further, the invention provides recombinant antibodies, such as humanized antibodies, against mammalian metapneumovirus, and methods for producing such recombinant antibodies. The invention further provides methods for treating, managing, ameliorating symptoms of and/or preventing infections with mammalian metapneumovirus, such as human metapneumovirus.Type: ApplicationFiled: September 14, 2009Publication date: September 23, 2010Applicant: Medimmune, LLCInventors: Nancy Ulbrandt, JoAnn Suzich, Kathleen L. Coelingh
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Patent number: 7390487Abstract: Disclosed are chimeric HPV L1 proteins and virus like particles comprising the same which are capable of generating high titer neutralizing antibody responses against at least two HPV types. The disclosed chimeric HPV L1 proteins and VLPs are useful as therapeutic and prophylactic reagents, as well as reagents for diagnosing papillomavirus infection.Type: GrantFiled: June 16, 2005Date of Patent: June 24, 2008Assignee: Med Immune, Inc.Inventors: Susan D. Wilson, Wendy White, JoAnn Suzich, Brian Mullikin
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Publication number: 20060228367Abstract: The present invention provides antibodies that immunospecifically bind to a polypeptide of a mammalian metapneumovirus, compositions comprising said antibodies, and methods for producing such antibodies. In particular, the invention provides monoclonal antibodies that immunospecifically bind to the F protein of human metapneumovirus and that neutralize human metapneumovirus. The invention also provides antibodies that cross-react with both the F protein of a mammalian metapneumovirus and the F protein of a mammalian respiratory syncytial virus and that neutralize both viruses. Further, the invention provides recombinant antibodies, such as humanized antibodies, against mammalian metapneumovirus, and methods for producing such recombinant antibodies. The invention further provides methods for treating, managing, ameliorating symptoms of and/or preventing infections with mammalian metapneumovirus, such as human metapneumovirus.Type: ApplicationFiled: February 15, 2006Publication date: October 12, 2006Inventors: Nancy Ulbrandt, JoAnn Suzich, Kathleen Coelingh
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Publication number: 20060127979Abstract: Disclosed are chimeric HPV L1 proteins and virus like particles comprising the same which are capable of generating high titer neutralizing antibody responses against at least two HPV types. The disclosed chimeric HPV L1 proteins and VLPs are useful as therapeutic and prophylactic reagents, as well as reagents for diagnosing papillomavirus infection.Type: ApplicationFiled: June 16, 2005Publication date: June 15, 2006Inventors: Susan Wilson, Wendy White, JoAnn Suzich, Brian Mullikin
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Patent number: 6908613Abstract: Disclosed are chimeric HPV L1 proteins and virus like particles comprising the same which are capable of generating high titer neutralizing antibody responses against at least two HPV types. The disclosed chimeric HPV L1 proteins and VLPs are useful as therapeutic and prophylactic reagents, as well as reagents for diagnosing papillomavirus infection.Type: GrantFiled: June 8, 2001Date of Patent: June 21, 2005Assignee: MedImmune, Inc.Inventors: Susan D. Wilson, Wendy White, JoAnn Suzich, Brian Mullikin
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Publication number: 20040224305Abstract: Disclosed are chimeric HPV L1 proteins and virus like particles comprising the same which are capable of generating high titer neutralizing antibody responses against at least two HPV types. The disclosed chimeric HPV L1 proteins and VLPs are useful as therapeutic and prophylactic reagents, as well as reagents for diagnosing papillomavirus infection.Type: ApplicationFiled: June 8, 2001Publication date: November 11, 2004Inventors: Susan D. Wilson, Wendy White, JoAnn Suzich, Brian Mullikin
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Publication number: 20030096259Abstract: A method of disassembly/reassembly of papillomavirus VLPs is provided. The resultant VLPs have enhanced homogeneity, present conformational, neutralizing PV epitopes, and therefore are useful prophylactic and diagnostic agents. Further, these VLPs can be used to encapsulate desired moieties, e.g., therapeutic or diagnostic agents, or “marker” DNAs, and the resultant VLPs used as in vivo delivery vehicles or as pseudovirions for evaluating vaccine efficacy.Type: ApplicationFiled: May 6, 2002Publication date: May 22, 2003Applicant: Medlmmune, Inc.Inventors: Michael P. McCarthy, JoAnn A. Suzich
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Publication number: 20020160358Abstract: The present invention provides an assay for measuring the immunogenicity of a vaccine, wherein the vaccine contains an epitope having a conformation associated with an immunogenically active form of the vaccine and a fragment having a conformation associated with an immunogenically inactive form of the vaccine, wherein the method includes exposing a sample of the vaccine to a first ligand capable of binding to the epitope in the conformation associated with the immunogenically active form of the vaccine and a second ligand capable of binding to the fragment in the conformation associated with the immunogenically inactive form of the vaccine and measuring the amount of first ligand bound to the vaccine sample and the amount of the second ligand bound to the vaccine sample.Type: ApplicationFiled: September 18, 2001Publication date: October 31, 2002Applicant: MedImmune, Inc.Inventors: Mark Allen Schenerman, Sheau-Chiann Wang, Robert Joseph Strouse, JoAnn Suzich, Wendy I. White
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Patent number: 6416945Abstract: A method of disassembly/reassembly of papillomavirus VLPs is provided. The resultant VLPs have enhanced homogeneity, present conformational, neutralizing PV epitopes, and therefore are useful prophylactic and diagnostic agents. Further, these VLPs can be used to encapsulate desired moieties, e.g., therapeutic or diagnostic agents, or “marker” DNAs, and the resultant VLPs used as in vivo delivery vehicles or as pseudovirions for evaluating vaccine efficacy.Type: GrantFiled: August 24, 1999Date of Patent: July 9, 2002Assignee: Medimmune, Inc.Inventors: Michael P. McCarthy, JoAnn Suzich
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Publication number: 20020018780Abstract: The present invention relates to a vaccine that comprises selected epitopes within the F protein structure that have been proven to specifically interact with known potent neutralizing antibodies while simultaneously being presented as part of a synthetic structure that offers these epitopes apart from the other non-neutralizing antigenic determinants of the virus but held in a native conformational form and thereby capable of eliciting neutralizing antibodies.Type: ApplicationFiled: May 25, 2001Publication date: February 14, 2002Inventors: Scott Koenig, Mark S. Hanson, JoAnn Suzich, Nancy Ulbrandt
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Patent number: 6261765Abstract: A method of disassembly/reassembly of papillomavirus VLPs is provided. The resultant VLPs have enhanced homogeneity, present conformational, neutralizing PV epitopes, and therefore are useful prophylactic and diagnostic agents. Further, these VLPs can be used to encapsulate desired moieties, e.g., therapeutic or diagnostic agents, or “marker” DNAs, and the resultant VLPs used as in vivo delivery vehicles or as pseudovirions for evaluating vaccine efficacy.Type: GrantFiled: August 24, 1999Date of Patent: July 17, 2001Assignee: MedImmune, Inc.Inventors: Michael P. McCarthy, JoAnn Suzich
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Patent number: 6165471Abstract: The present invention relates to stable HPV capsomeres which express at least one virus-neutralizing conformational epitope of a native HPV L1 protein which are substantially incapable of assembly into virus-like particles. These capsomeres, because of their smaller size, and immunogenic properties are well suited for use in HPV vaccines and as diagnostic agents. Moreover, because of their smaller size (relative to VLPs), these stable capsomeres may be easily purified and should result in HPV vaccines of enhanced homogeneity.Type: GrantFiled: July 2, 1998Date of Patent: December 26, 2000Assignees: University of Colorado, University Technology Corporation, MedImmune, Inc., University of Rochester, Office of Research and Project Administration and Institute of Higher EducationInventors: Robert L. Garcea, JoAnn A. Suzich, Michael P. McCarthy, Robert C. Rose