Patents by Inventor Joanna Bakala
Joanna Bakala has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20210188911Abstract: The object of the present invention relates to a novel family of peptide conjugates of formula (I): A-X1—X2-Pro-Ala-X—B ??(I) wherein: A represents a hydrogen atom, a C6 to C20 acyl group or a cholesterol residue; X1 represents a covalent bond, an alanine or a proline; X2 represents an arginine, a lysine, or an alanine; X represents a lysine, an alanine, or a phenylalanine; and B represents a hydroxyl or an amine; or one of its preferentially pharmaceutically, dermatologically or cosmetically acceptable salts, as well as their synthesis processes and their uses for reducing hair loss and stimulating hair growth.Type: ApplicationFiled: January 27, 2021Publication date: June 24, 2021Applicants: Institut Europeen de Biologie Cellulaire, Centre de Recherches Biologiques et d'Experimentations Cutanees, Centre National de la Recherche Scienfitique (CNRS)Inventors: Michel Hocquaux, Stéphanie Almeida Épouse Scalvino, Elian Lati, Joanna Bakala
-
Patent number: 10947273Abstract: The object of the present invention relates to a novel family of peptide conjugates of formula (I): A-X1-X2-Pro-Ala-X—B??(I) wherein: A represents a hydrogen atom, a C6 to C20 acyl group or a cholesterol residue; X1 represents a covalent bond, an alanine or a proline; X2 represents an arginine, a lysine, or an alanine; X represents a lysine, an alanine, or a phenylalanine; and B represents a hydroxyl or an amine; or one of its preferentially pharmaceutically, dermatologically or cosmetically acceptable salts, as well as their synthesis processes and their uses for reducing hair loss and stimulating hair growth.Type: GrantFiled: October 10, 2016Date of Patent: March 16, 2021Assignees: Institut European de Biologic Cellulaire, Centre de Recherches Biologiques et d'Experimentations Cutanees, Centre National de la Recherche Scientifique (CNRS)Inventors: Michel Hocquaux, Stéphanie Almeida Épouse Scalvino, Elian Lati, Joanna Bakala
-
Patent number: 10653694Abstract: The invention relates to compounds which are inhibitors of the polymerization of tubulin, to the methods for the production thereof, and to the uses of same.Type: GrantFiled: April 9, 2015Date of Patent: May 19, 2020Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE PARIS-SUDInventors: Mouad Alami, Jean-Daniel Brion, Samir Messaoudi, Olivier Provot, Mohamed-Ali Soussi, Jerome Bignon, Joelle Dubois, Joanna Bakala-Wdzieczak
-
Patent number: 10233151Abstract: The present invention relates to a 3-aryl-4 catechol-pyrrole-n-propanol compound and the derivatives thereof having General Formula (I), wherein:—R1 is an aryl group, particularly a phenyl, optionally substituted by one or more (C1-C2)alkyl groups, one or more halogens, one or more —OH, —CN or CF3 groups, or a combination of same, and—R2 is a (C1-C6)alkyl group, a hydroxy(C1-C6)alkyl group, a (C1-C4)alcoxy(C1-C6)alkyl group, or a pharmaceutically acceptable hydrate or solvate of same. The invention also relates to the methods for preparing said compound and derivatives, to the pharmaceutical compositions containing same, and to the use of same as a drug or in the form of a prodrug converted via dimerization, particularly via oxidative coupling in the presence of a superoxide anion, in the treatment of cancer and diseases related to excessive angiogenesis.Type: GrantFiled: June 17, 2015Date of Patent: March 19, 2019Assignee: Centre National de la Recherche Scientifique (CNRS)Inventors: Pascal Collin, Bernard Delpech, Joanna Bakala, Bogdan Iorga, Yves-Michel Frapart-Jannuad, Fabienne Peyrot, Franck Pelissier, Maria Conception Achab
-
Publication number: 20180291061Abstract: The object of the present invention relates to a novel family of peptide conjugates of formula (I): A-X1-X2-Pro-Ala-X-B??(I) wherein: A represents a hydrogen atom, a C6 to C20 acyl group or a cholesterol residue; X1 represents a covalent bond, an alanine or a proline; X2 represents an arginine, a lysine, or an alanine; X represents a lysine, an alanine, or a phenylalanine; and B represents a hydroxyl or an amine; or one of its preferentially pharmaceutically, dermatologically or cosmetically acceptable salts, as well as their synthesis processes and their uses for reducing hair loss and stimulating hair growth.Type: ApplicationFiled: October 10, 2016Publication date: October 11, 2018Applicants: Institut Europeen de Biologie Cellulaire, Centre de Recherches Biologiques et d'Experimentations Cutanees, Centre National de la Recherche Scienfitique (CNRS)Inventors: Michel Hocquaux, Stéphanie Almeida Épouse Scalvino, Elian Lati, Joanna Bakala
-
Publication number: 20170121283Abstract: The present invention relates to a 3-aryl-4 catechol-pyrrole-n-propanol compound and the derivatives thereof having General Formula (I), wherein:—R1 is an aryl group, particularly a phenyl, optionally substituted by one or more (C1-C2)alkyl groups one or more halogens, one or more —OH, —CN or CF3 groups, or a combination of same, and—R2 is a (C1-C2)alkyl group, a hydroxy(C1-C8)alkyl group, a (C1-C4)alocoxy(C1-C8)alkyl group, or a pharmaceutically acceptable hydrate or solvate of same. The invention also relates to the methods for preparing said compound and derivatives, to the pharmaceutical compositions containing same, and to the use of same as a drug or in the form of a prodrug converted via dimerization, particularly via oxidative coupling in the presence of a superoxide anion, in the treatment of cancer and diseases related to excessive angiogenesis.Type: ApplicationFiled: June 17, 2015Publication date: May 4, 2017Applicant: Centre National de la Recherche Scientifique (CNRS)Inventors: Pascal Collin, Bernard Delpech, Joanna Bakala, Bogdan Iorga, Yves-Michel Frapart-Jannuad, Fabienne Peyrot, Franck Pelissier, Maria Conception Achab
-
Publication number: 20170035761Abstract: The invention relates to compounds which are inhibitors of the polymerization of tubulin, to the methods for the production thereof, and to the uses of same.Type: ApplicationFiled: April 9, 2015Publication date: February 9, 2017Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE PARIS-SUDInventors: Mouad ALAMI, Jean-Daniel BRION, Samir MESSAOUDI, Olivier PROVOT, Mohamed-Ali SOUSSI, Jerome BIGNON, Joelle DUBOIS, Joanna BAKALA-WDZIECZAK
-
Patent number: 9546159Abstract: The present invention relates to a compound of formula (I) in which: -m is an integer from 0 to 3, preferably from 0 to 2; n is an integer from 0 to 3, preferably from 0 to 2; m+n?1; EAG is an electro-attractive group chosen independently from among a halogen atom, an NO2, CF3, CCI3, CN, CO2H, (C?O)NR2, CH?NR, (C?S)OR, (C?O)SR, CS2R, SO2R, SO2NR2, SO3R, P(O)(OR)2, P(O)(R)2, B(OR)2 group where R is a (C1-C6) alkyl radical, a phenyl group or a hydrogen atom; A is a saturated or unsaturated, linear or branched hydrocarbon chain including 1 to 10 atoms of carbon; and R1 and R2 each represent independently from one another a hydrogen atom, a CO-(Ci-C6)-alkyl, (C1-C6) alkyl, phenyl or phenyl-(C1-C6)-alkyl group, in which R1 and R2 form, together with the nitrogen atom they carry, a 5- to 15-member heterocycle, optionally substituted by a (C1-C6) alkyl group; including its stereoisomers and the mixtures thereof, or a pharmaceutically acceptable salt of same.Type: GrantFiled: October 14, 2013Date of Patent: January 17, 2017Assignee: Centre National de la Recherche Scientifique (CNRS)Inventors: Pascal Collin, Maxim Egorov, Bernard Delpech, Joanna Bakala, Maria Achab, Jérome Bignon, Odile Thoison, Michel Benechie
-
Patent number: 9512176Abstract: The invention relates to a compound having general formula I, wherein: X represents CH2, C?O, C?S or CHOH, R1 represents an amino acid optionally substituted by one or more halogen atoms, or by one or more CF3 groups and n=0.1 or 2, or R1 represents a peptide containing two amino acids, each amino acid being optionally substituted by one or more halogen atoms, or by one or more CF3 groups and n=0 or 1, or XR1 represent PO3H or SO3H and n=0.1 or 2; R2 represents H, XR1, an alkyl group at C1-C6, an aralkyl group at C1-C6 or an aryl group, whereby the alkyl, aralkyl and aryl groups can be substituted by an amine NH2, a carboxylic group COOH, one or more halogen atoms.Type: GrantFiled: April 2, 2012Date of Patent: December 6, 2016Assignee: Centre National de la Recherche ScientifiqueInventors: Pierre Potier, Guy Jean Marie Potier, Marie-Claude Denise Michele Zelveyan, Catherine Marie Germaine Magnan, Odette Drion, Nobumichi Andre Sasaki, Maria Concepcion Achab Garcia Alvarez, Qian Wang-Zhu, Lioudmila Ermolenko, Joanna Bakala, Gisele Franck, Naima Bakrim Nhiri
-
Publication number: 20150344460Abstract: The present invention relates to a compound of formula (I) in which: —m is an integer from 0 to 3, preferably from 0 to 2; n is an integer from 0 to 3, preferably from 0 to 2; m+n?1; EAG is an electro-attractive group chosen independently from among a halogen atom, an NO2, CF3, CCI3, CN, CO2H, (C?O)NR2, CH?NR, (C?S)OR, (C?O)SR, CS2R, SO2R, SO2NR2, SO3R, P(O)(OR)2, P(O)(R)2, B(OR)2 group where R is a (C1-C6) alkyl radical, a phenyl group or a hydrogen atom; A is a saturated or unsaturated, linear or branched hydrocarbon chain including 1 to 10 atoms of carbon; and R1 and R2 each represent independently from one another a hydrogen atom, a CO-(Ci-C6)-alkyl, (C1-C6) alkyl, phenyl or phenyl-(C1-C6)-alkyl group, in which R1 and R2 form, together with the nitrogen atom they carry, a 5- to 15-member heterocycle, optionally substituted by a (C1-C6) alkyl group; including its stereoisomers and the mixtures thereof, or a pharmaceutically acceptable salt of same.Type: ApplicationFiled: October 14, 2013Publication date: December 3, 2015Inventors: Pascal Collin, Maxim Egorov, Bernard Delpech, Joanna Bakala, Maria Achab, Jérome Bignon, Odile Thoison, Michel Benechie
-
Patent number: 8697652Abstract: This invention relates to the cosmetic use of at least one compound of formula (I) wherein A1 is the radical corresponding to D- or L-Ser A2 is the radical corresponding to D- or L-Asp or Glu, A3 is the radical corresponding to D- or L-Lys, Arg or Orn, A4 is the radical corresponding to D- or L-pro, R1, R2 and R3 are as defined in the claims as anti-aging and restructuring agents.Type: GrantFiled: June 22, 2005Date of Patent: April 15, 2014Assignee: Centre National de la Recherche Scientifique (CNRS)Inventors: Joanna Bakala, Jean-Yves Lallemand, Jian-Miao Liu, Jérôme Bignon
-
Publication number: 20120252866Abstract: The invention relates to a compound having general formula I, wherein: X represents CH2, C?O, C?S or CHOH, R1 represents an amino acid optionally substituted by one or more halogen atoms, or by one or more CF3 groups and n=0.1 or 2, or R1 represents a peptide containing two amino acids, each amino acid being optionally substituted by one or more halogen atoms, or by one or more CF3 groups and n=0 or 1, or XR1 represent PO3H or SO3H and n=0.1 or 2; R2 represents H, XR1, an alkyl group at C1-C6, an aralkyl group at C1-C6 or an aryl group, whereby the alkyl, aralkyl and aryl groups can be substituted by an amine NH2, a carboxylic group COOH, one or more halogen atoms.Type: ApplicationFiled: April 2, 2012Publication date: October 4, 2012Applicants: Centre National De La Recherche Scientifique (CNRS), PHARMAMENSInventors: Pierre Potier, Guy Jean Marie Potier, Marie Claude Denise Michele Zelveyan, Catherine Marie Germaine Magnan, Odette Drion, Nobumichi André Sasaki, Maria Concepcion Achab Garcia Alvarez, Qian Wang-Zhu, Lioudmila Ermolenko, Joanna Bakala, Gisèle Franck, Naïma Bakrim Nhiri
-
Patent number: 8273768Abstract: The invention relates to a compound of the formula (I) in which: R1, R2 and R3 are independently a methoxy group optionally substituted by one or more fluorine atoms; R4 is a hydrogen atom; R5 and R6 are identical and each represent a hydrogen or fluorine atom; A is a cycle selected from the group including aryl and heteroaryl groups, wherein said groups can be substituted.Type: GrantFiled: April 4, 2008Date of Patent: September 25, 2012Assignee: Centre National de la Recherche Scientifique (CNRS)Inventors: Mouâd Alami, Jean-Daniel Brion, Olivier Provot, Jean-François Peyrat, Samir Messaoudi, Abdallah Hamze, Anne Giraud, Jérôme Bignon, Joanna Bakala, Jian-Miao Liu
-
Publication number: 20110160228Abstract: The present invention relates to compounds of formula (I) below in which: —R1 and R3 represent, independently of one another, a methoxy group optionally substituted by one or more fluorine atoms, —R2 and R4 represent, independently of one another, a hydrogen atom or a methoxy group optionally substituted by one or more fluorine atoms, —A represents a ring chosen from the group comprising aryl and heteroaryl groups, said ring possibly being substituted by or fused to a heterocycle, —X represents a nitrogen atom or a CH group, and —Z1 represents a hydrogen atom or a halogen atom, preferably fluorine, and —Z2 represents a hydrogen atom, a halogen atom, preferably fluorine, a C1 to C4 alkyl group, an aryl group or a —CN, —SO2NR12R13, —SO2R9, —COOR15 or —COR15 group, and also to the pharmaceutically acceptable salts thereof, the isomers thereof and the prodrugs thereof.Type: ApplicationFiled: June 4, 2009Publication date: June 30, 2011Inventors: Mouâd Alami, Samir Messaoudi, Abdallah Hamze, Olivier Provot, Jean-Daniel Brion, Jian-Miao Liu, Jérôme Bignon, Joanna Bakala
-
Publication number: 20100129471Abstract: The invention relates to a compound of the formula (I) in which: R1, R2 and R3 are independently a methoxy group optionally substituted by one or more fluorine atoms; R4 is a hydrogen atom; R5 and R6 are identical and each represent a hydrogen or fluorine atom; A is a cycle selected from the group including aryl and heteroaryl groups, wherein said groups can be substituted.Type: ApplicationFiled: April 4, 2008Publication date: May 27, 2010Inventors: Mouâd Alami, Jean-Daniel Brion, Olivier Provot, Jean-François Peyrat, Samir Messaoudi, Abdallah Hamze, Anne Giraud, Jérôme Bignon, Joanna Bakala, Jian-Miao Liu
-
Patent number: 7405309Abstract: The invention relates to pyranone derivatives of general formula (I), wherein X is chlorine, bromine or iodine and R1 and R2 is independently a hydrogen atom, an alkyl, cycloalkyl or alkylene, linear or branched group containing 1-20 carbon atoms, optionally substituted by a hydroxyl, amino, ether or halogen group, or R1 and R2 form together a cycle of 5, 6, 7 or 8 members which is optionally substituted by a hydroxyl, amino, ether or halogen group including isomers, enantiomers, diastereoisomers and the mixtures thereof. A method for preparing the inventive derivatives and the therapeutic use thereof, in particular for treating cancer, are also disclosed.Type: GrantFiled: January 14, 2005Date of Patent: July 29, 2008Assignee: Centre National de la Recherche Scientifique (CNRS)Inventors: Joanna Bakala, Denyse Herlem, Emile Benechie, Jérôme Bignon, Françoise Khuong-Huu, Guy Jean Marie Potier, legal representative, Marie-Claude Denise Michèle Zelveyan, legal representative, Catherine Marie Germaine Magnan, legal representative, Odette Drion, legal representative, Pierre Potier
-
Publication number: 20070259819Abstract: This invention relates to the cosmetic use of at least one compound of formula (I) wherein A1 is the radical corresponding to D- or L-Ser A2 is the radical corresponding to D- or L-Asp or Glu, A3 is the radical corresponding to D- or L-Lys, Arg or Orn, A4 is the radical corresponding to D- or L-pro, R1, R2 and R3 are as defined in the claims as anti-aging and restructuring agents.Type: ApplicationFiled: June 22, 2005Publication date: November 8, 2007Inventors: Joanna Bakala, Jean-Yves Lallemand, Jian-Miao Liu, Jerome Bignon
-
Publication number: 20070167515Abstract: The invention relates to pyranone derivatives of general formula (I), wherein X is chlorine, bromine or iodine and R1 and R2 is independently a hydrogen atom, an alkyl, cycloalkyl or alkylene, linear or branched group containing 1-20 carbon atoms, optionally substituted by a hydroxyl, amino, ether or halogen group, or R1 and R2 form together a cycle of 5, 6, 7 or 8 members which is optionally substituted by a hydroxyl, amino, ether or halogen group including isomers, enantiomers, diastereoisomers and the mixtures thereof. A method for preparing the inventive derivatives and the therapeutic use thereof, in particular for treating cancer, are also disclosed.Type: ApplicationFiled: January 14, 2005Publication date: July 19, 2007Inventors: Joanna Bakala, Denyse Herlem, Emile Benechie, Jerome Bignon, Francoise Khuong-Huu, Pierre Potier
-
Patent number: 7235532Abstract: The present invention relates to the use of a compound of formula I: in which, A1 is the radical corresponding to D- or L-Ser, A2 is the radical corresponding to D- or L-Asp or Glu, A3 is the radical corresponding to D- or L-Lys, Arg or Gm, A4 is the radical corresponding to D- or L-Pro, R1 and R2 are chosen, independently, from H, C1–C12-alkyl which may or may not be substituted, C7–C20-arylalkyl which may or may not be substituted, R4CO or R4COO, R4 being C1–C12-alkyl which may or may not be substituted, or C7–C20-arylalkyl which may or may not be substituted; among the substitutions, mention should be made of OH, NH2 or COOH, X1 and X2 are peptide or pseudopeptide bonds, X3 is CO or CH2 and R3 is OH, NH2, C1–C1-alkoxy or NH-X4-CH2-Z, X4 is a normal or branched C1–C12 hydrocarbon, and Z is H, OH, CO2H or CONH2, or the corresponding tripeptides comprising the radicals A1, A2, A3, and also the pharmacautically acceptable salts, for the preparation of a medicament for treating pathologies which may benefType: GrantFiled: September 20, 2001Date of Patent: June 26, 2007Assignee: Centre National de la Recherche ScientfiqueInventors: Joanna Bakala, Jean-Paul Pierre Potier, Françoise Lawrence, Nathalie Cheviron, Jérôme Bignon, Yves Fromes
-
Patent number: 7199159Abstract: The present invention relates to the use of biguanide derivatives of general formula I below: in which: the groups R1 and R2 represent, independently of each other, a hydrogen atom, a C1–C7, alkyl group, a cycloalkyl group, a heterocycle, a C2–C7 alkenyl group, an aryl group, an aralkyl group, an aryloxyalkyl group or a heteroaryl group, or R1 and R2, taken together, represent a C2–C7 alkylene which may contain one or more hetero atoms, and the group R3 represents a primary, secondary or tertiary amine, or pharmaceutically acceptable salts thereof, to manufacture a medicinal product with cicatrizing action, the said medicinal product being in a pharmaceutical form for topical use.Type: GrantFiled: May 23, 2001Date of Patent: April 3, 2007Assignee: Centre National de la Recherche Scientifique (C.N.R.S.)Inventors: Pierre Jean-Paul Potier, Nobumichi-André Sasaki, Maria Conception Achab, Gisèle Franck, Claude Thal, Joanna Bakala