Abstract: The present invention provides method for predicting risk of cervical shortening, methods for predicting risk of preterm labour (PTL), and methods for characterising a pregnant subject having a history of previous PTL, mid-trimester loss or cervical cone biopsy as being in need of surveillance and/or intervention to prevent preterm labour, comprising determining the expression level of one or more of the miRNA molecules identified in Table 1 or Table 2 extracted from a biological sample obtained from said subject and comparing to a control value. Biochips and kits for use in carrying out the methods of the invention are also provided.

Abstract: The present invention provides method for predicting risk of cervical shortening, methods for predicting risk of preterm labour (PTL), and methods for characterising a pregnant subject having a history of previous PTL, mid-trimester loss or cervical cone biopsy as being in need of surveillance and/or intervention to prevent preterm labour, comprising determining the expression level of one or more of the miRNA molecules identified in Table 1 or Table 2 extracted from a biological sample obtained from said subject and comparing to a control value. Biochips and kits for use in carrying out the methods of the invention are also provided.

Abstract: The present invention provides method for predicting risk of cervical shortening, methods for predicting risk of preterm labour (PTL), and methods for characterising a pregnant subject having a history of previous PTL, mid-trimester loss or cervical cone biopsy as being in need of surveillance and/or intervention to prevent preterm labour, comprising determining the expression level of one or more of the miRNA molecules identified in Table 1 or Table 2 extracted from a biological sample obtained from said subject and comparing to a control value. Biochips and kits for use in carrying out the methods of the invention are also provided.

Abstract: The present invention provides method for predicting risk of cervical shortening, methods for predicting risk of preterm labour (PTL), and methods for characterising a pregnant subject having a history of previous PTL, mid-trimester loss or cervical cone biopsy as being in need of surveillance and/or intervention to prevent preterm labour, comprising determining the expression level of one or more of the miRNA molecules identified in Table 1 or Table 2 extracted from a biological sample obtained from said subject and comparing to a control value. Biochips and kits for use in carrying out the methods of the invention are also provided.

Abstract: Embodiments of the invention provide a method for manipulating the position and appearance of shadows cast by light striking objects within a three dimensional model. Typically, the location and appearance of shadows are determined using the position of a distant light source. A user selects a point from within a shadow bounded region to drag from an initial position to a destination position. Once a point is selected, the position of the light source may be adjusted about a pivot point. The adjusted position of the light source is determined based on the position of the destination position and the position of the pivot point within the 3D model.

Abstract: Embodiments of the invention provide a method for manipulating the position and appearance of shadows cast by light striking objects within a three dimensional model. Typically, the location and appearance of shadows are determined using the position of a distant light source. A user selects a point from within a shadow bounded region to drag from an initial position to a destination position. Once a point is selected, the position of the light source may be adjusted about a pivot point. The adjusted position of the light source is determined based on the position of the destination position and the position of the pivot point within the 3D model.