Publication number: 20090062380
Abstract: The invention relates to the medical use of natural isoflavones and their semisynthetic derivatives or the pharmaceutically acceptable salts thereof for the therapeutic and/or prophylactic treatment of diseases, at the base of which lies an excessive production or storage of glycosaminoglycans, especially for treatment of mucopolysaccharidoses. The isoflavones and their semisynthetic derivatives are represented by formula (I), in which R1 and R2 are the same or different and are independently H or alkyl, alkenyl, aryl alkylaryl, alkylcarbonyl, arylcarbonyl or mono-, di- or oligosaccharide group, each of then optionally substituted by at least one acyl, alkyl, cycloalkyl, alkoxyalkyl, aryl, alkylaryl, carboxyl or cyano; and R3 is H, acyl or alkyl.
Type:
Application
Filed:
September 21, 2006
Publication date:
March 5, 2009
Applicant:
INSTYTUT FARMACEUTYCZNY
Inventors:
Grzegorz Grynkiewicz, Grzegorz Wegrzyn, Barbara Szechner, Wieslaw Szeja, Anna Tylki-Szymanska, Alicja Wegrzyn, Joanna Jakobkiewicz-Banecka, Sylwia Baranska, Barbara Czartoryska, Ewa Piotrowska