Abstract: A computer implemented method, apparatus, and computer program product for analyzing neurological images. A set of brain scans for a patient is compared to a set of baseline control scans to automatically identify regions of interest in the set of patient scans. A region of interest is an area in a scan that shows an indication of a potential abnormality. A set of electronic medical literature sources is searched for medical literature relevant to the regions of interest in the set of patient scans. The relevant medical literature is correlated to the medical literature describing the regions of interest in the set of patient scans to the regions of interest in the set of patient scans. A result is generated. The result comprises the regions of interest and a set of links to the correlated portions of the relevant medical literature are outputted.

Abstract: A computer implemented method, apparatus, and computer program product of determining mechanisms of action for therapies. A first set of brain scans for each subject in a plurality of subjects generated at a first time period and a second set of brain scans for each subject generated at a second time period are received. Each subject is diagnosed with a given condition and received a given therapy. A set of changes in the set of brain scans is identified for the each subject based on a comparison of a first set of regions of interest in the first set of scans for each subject with a second set of regions of interest in the second set of scans for each subject. A set of typical changes attributable to the given therapy is identified. A mechanism of action for the given therapy is generated based on the set of typical changes.

Abstract: A computer implemented method, apparatus, and computer program product for modifying neuropsychiatric treatment plans based on efficacy of treatment. A current treatment plan comprising a first set of therapies to treat a set of neuropsychiatric conditions and portions of the medical literature associated with the set of neuropsychiatric conditions is retrieved. A set of brain scans of the patient is analyzed to determine a set of changes over time associated with the set of neuropsychiatric conditions. The portions of the medical literature and the set of changes are analyzed to determine a patient rate of response to the treatment plan. If the patient rate of response falls below a threshold expected rate, a set of alternative treatments for the patient is identified. A modified treatment plan is generated using the set of alternative treatments.

Abstract: A computer implemented method, apparatus, and computer program product for generating neuropsychiatric diagnoses. Quantitative information describing diagnostic characteristics associated with a patient is generated based on an analysis of a set of patient scans. The quantitative information comprises a set of indictors associated with regions of interest in the set of scans for the patient. The set of indicators of potential neuropsychiatric conditions is compared with a set of diagnostic signatures. A diagnostic signature comprises a set of indicators of a known neuropsychiatric condition. Matching signatures are identified. A matching signature is a diagnostic signature that corresponds to at least one indicator in the set of indicators to form a set of signatures. A diagnosis associated with each signature in the set of signatures is identified to form a set of potential diagnoses. The set of potential diagnoses is presented with links to relevant portion of the medical literature.

Abstract: A computer implemented method, apparatus, and computer program product for analyzing neurological images. A set of brain scans for a patient is compared to a set of baseline control scans to automatically identify regions of interest in the set of patient scans. A region of interest is an area in a scan that shows an indication of a potential abnormality. A set of electronic medical literature sources is searched for medical literature relevant to the regions of interest in the set of patient scans. The relevant medical literature is correlated to the medical literature describing the regions of interest in the set of patient scans to the regions of interest in the set of patient scans. A result is generated. The result comprises the regions of interest and a set of links to the correlated portions of the relevant medical literature are outputted.

Abstract: A computer implemented method, apparatus, and computer program product for analyzing neurological images. A set of brain scans for a patient is compared to a set of baseline control scans to automatically identify regions of interest in the set of patient scans. A region of interest is an area in a scan that shows an indication of a potential abnormality. A set of electronic medical literature sources is searched for medical literature relevant to the regions of interest in the set of patient scans. The relevant medical literature is correlated to the medical literature describing the regions of interest in the set of patient scans to the regions of interest in the set of patient scans. A result is generated. The result comprises the regions of interest and a set of links to the correlated portions of the relevant medical literature are outputted.

Abstract: A computer implemented method, apparatus, and computer program product for determining the efficacy of neuropsychiatric therapy is provided. A neuroimage mapping manager automatically compares a first set of regions of interest in a first set of scans taken at a first time to a second set of regions of interest in a second set of scans generated at a second time and identifies a set of changes in the regions of interest occurring over time. The neuroimage mapping manager searches a set of electronic medical literature sources for medical literature relevant to the set of changes in the regions of interest and identifies portions of the relevant medical literature associated with the set of changes in the regions of interest. The neuroimage mapping manager generates results comprising the set of changes in the regions of interest and a set of links to the portions of the relevant medical literature.

Abstract: A computer implemented method for generating optimized pharmaceutical treatment plans for an individual. A set of known treatments to be used by the target individual over a future period of time is generated. An actual use of the treatments in the set of known treatments by the target individual during the future period of time is substantially certain. A set of probable treatments of the target individual is received. The actual use of the treatments in the set of probable treatments by the target individual during the future period of time is uncertain. An optimized pharmaceutical treatment plan for the target individual is generated. The optimized pharmaceutical treatment plan comprises medications and durable medical goods that are likely to be used by the target individual over the future period of time optimized over a set of dimensions associated with the set of known treatments and the set of probable treatments.

Abstract: A computer implemented method, apparatus, and computer program product for developing neuropsychiatric treatment plans. A treatment plan generator receives a set of diagnoses for a patient. The treatment plan generator automatically analyzes medical information in a set of electronic medical literature sources for potential therapies associated with treatment of each identified condition in the set of diagnoses. The treatment plan generator identifies the potential therapies associated with the treatment of each diagnosed condition. The treatment plan generator selects a set of recommended therapies from the potential therapies based on portions of the medical literature describing each therapy in the potential therapies and a medical history for the patient. The treatment plan generator generates a treatment plan. The treatment plan comprises the set of recommended therapies to treat each diagnosed condition in the set of diagnoses.

Abstract: A computer implemented method, apparatus, and computer program product for generating neuropsychiatric diagnoses. Quantitative information describing diagnostic characteristics associated with a patient is generated based on an analysis of a set of patient scans. The quantitative information comprises a set of indictors associated with regions of interest in the set of scans for the patient. The set of indicators of potential neuropsychiatric conditions is compared with a set of diagnostic signatures. A diagnostic signature comprises a set of indicators of a known neuropsychiatric condition. Matching signatures are identified. A matching signature is a diagnostic signature that corresponds to at least one indicator in the set of indicators to form a set of signatures. A diagnosis associated with each signature in the set of signatures is identified to form a set of potential diagnoses. The set of potential diagnoses is presented with links to relevant portion of the medical literature.

Abstract: A computer implemented method, apparatus, and computer program product for developing neuropsychiatric treatment plans. A treatment plan generator receives a set of diagnoses for a patient. The treatment plan generator automatically analyzes medical information in a set of electronic medical literature sources for potential therapies associated with treatment of each identified condition in the set of diagnoses. The treatment plan generator identifies the potential therapies associated with the treatment of each diagnosed condition. The treatment plan generator selects a set of recommended therapies from the potential therapies based on portions of the medical literature describing each therapy in the potential therapies and a medical history for the patient. The treatment plan generator generates a treatment plan. The treatment plan comprises the set of recommended therapies to treat each diagnosed condition in the set of diagnoses.

Abstract: A computer implemented method, apparatus, and computer program product of determining mechanisms of action for therapies. A first set of brain scans for each subject in a plurality of subjects generated at a first time period and a second set of brain scans for each subject generated at a second time period are received. Each subject is diagnosed with a given condition and received a given therapy. A set of changes in the set of brain scans is identified for the each subject based on a comparison of a first set of regions of interest in the first set of scans for each subject with a second set of regions of interest in the second set of scans for each subject. A set of typical changes attributable to the given therapy is identified. A mechanism of action for the given therapy is generated based on the set of typical changes.

Abstract: A computer implemented method, apparatus, and computer program product for modifying neuropsychiatric treatment plans based on efficacy of treatment. A current treatment plan comprising a first set of therapies to treat a set of neuropsychiatric conditions and portions of the medical literature associated with the set of neuropsychiatric conditions is retrieved. A set of brain scans of the patient is analyzed to determine a set of changes over time associated with the set of neuropsychiatric conditions. The portions of the medical literature and the set of changes are analyzed to determine a patient rate of response to the treatment plan. If the patient rate of response falls below a threshold expected rate, a set of alternative treatments for the patient is identified. A modified treatment plan is generated using the set of alternative treatments.

Abstract: A computer implemented method, apparatus, and computer program product for analyzing neurological images. A set of brain scans for a patient is compared to a set of baseline control scans to automatically identify regions of interest in the set of patient scans. A region of interest is an area in a scan that shows an indication of a potential abnormality. A set of electronic medical literature sources is searched for medical literature relevant to the regions of interest in the set of patient scans. The relevant medical literature is correlated to the medical literature describing the regions of interest in the set of patient scans to the regions of interest in the set of patient scans. A result is generated. The result comprises the regions of interest and a set of links to the correlated portions of the relevant medical literature are outputted.

Abstract: A computer implemented method, apparatus, and computer program product for determining the efficacy of neuropsychiatric therapy is provided. A neuroimage mapping manager automatically compares a first set of regions of interest in a first set of scans taken at a first time to a second set of regions of interest in a second set of scans generated at a second time and identifies a set of changes in the regions of interest occurring over time. The neuroimage mapping manager searches a set of electronic medical literature sources for medical literature relevant to the set of changes in the regions of interest and identifies portions of the relevant medical literature associated with the set of changes in the regions of interest. The neuroimage mapping manager generates results comprising the set of changes in the regions of interest and a set of links to the portions of the relevant medical literature.

Abstract: A computer implemented method for generating optimized pharmaceutical treatment plans for an individual. A set of known treatments to be used by the target individual over a future period of time is generated. An actual use of the treatments in the set of known treatments by the target individual during the future period of time is substantially certain. A set of probable treatments of the target individual is received. The actual use of the treatments in the set of probable treatments by the target individual during the future period of time is uncertain. An optimized pharmaceutical treatment plan for the target individual is generated. The optimized pharmaceutical treatment plan comprises medications and durable medical goods that are likely to be used by the target individual over the future period of time optimized over a set of dimensions associated with the set of known treatments and the set of probable treatments.

Abstract: The invention provides MurD polypeptides and DNA (RNA) encoding MurD polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing MurD polypeptides to screen for antibacterial compounds.

Abstract: The invention provides ftsZ polypeptides and polynucleotides encoding ftsZ polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ftsZ polypeptides to screen for antibacterial compounds.

Abstract: The invention provides ftsZ polypeptides and polynucleotides encoding ftsZ polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ftsZ polypeptides to screen for antibacterial compounds.

Abstract: The invention provides mraY polypeptides and polynucleotides encoding mraY polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing mraY polypeptides to screen for antibacterial compounds.