Patents by Inventor Joanna Wietrzyk

Joanna Wietrzyk has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • AROMATIC SULPHONAMIDES DERIVATIVES THAT INHIBITS PDI A3, THEIR SYNTHESIS AND USE
    Publication number: 20230069886
    Abstract: The invention relates to a new group of aromatic sulphonamides derivatives of formula (I) and their synthesis and use for modulation of the activity of protein disulfide isomerase (PDI). More particularly, the invention provides small molecule inhibitors of PDI A3 that display antiplatelet, antithrombotic and anticancer activities.
    Type: Application
    Filed: January 10, 2020
    Publication date: March 9, 2023
    Inventors: Stefan CHLOPICKI, Ivars KALVINS, Kamil PRZYBOROWSKI, Marta STOJAK, Victor ANDRIANOV, Ilona DOMRACEVA, Iveta KANEPE-LAPSA, Diana ZELENCOVA, Joanna WIETRZYK, Eliza TURLEJ, Martyna STACHOWICZ, Joanna JAROSZ, Magdalena MILCZAREK, Karol KRAMKOWSKI
  • AROMATIC SULPHONAMIDES DERIVATIVES THAT INHIBITS PDI A3, THEIR SYNTHESIS AND USE
    Publication number: 20230039836
    Abstract: The invention relates to a new group of aromatic sulphonamides derivatives of formula (I) and their synthesis and use for modulation of the activity of protein disulfide isomerase (PDI). More particularly, the invention provides small molecule inhibitors of PDI A1 that display antiplatelet, antithrombotic and anticancer activities.
    Type: Application
    Filed: January 10, 2020
    Publication date: February 9, 2023
    Inventors: Ivars KALVINS, Stefan CHLOPICKI, Marta STOJAK, Victor ANDRIANOV, Ilona DOMRACEVA, Iveta KANEPE-LAPSA, Diana ZELENCOVA, Joanna WIETRZYK, Eliza TURLEJ, Martyna STACHOWICZ, Joanna JAROSZ, Magdalena MILCZAREK, Karol KRAMKOWSKI
  • Asymmetrically substituted anthrapyridazone derivatives as cytostatics
    Patent number: 9096536
    Abstract: The invention relates to the new, asymmetrically substituted derivatives of 2,7-dihydro-3H-dibenzo[de,h]cinnoline-3,7-dione and their use as cytostatics exhibiting activity against tumor cells, especially against cells with multidrug resistance (MDR). In particular, the invention concerns derivatives of 2,7-dihydro-3H-dibenzo[de,h]cinnoline-3,7-dione represented by the general formula (I).
    Type: Grant
    Filed: April 13, 2012
    Date of Patent: August 4, 2015
    Assignee: BS-154 S.P. ZO.O.
    Inventors: Edward Borowski, Barbara Stefanska, Maria Dzieduszycka, Marcin Cybulski, Wieslaw Szelejewski, Janusz Obukowicz, Maria Bontemps-Gracz, Malgorzata Wysocka, Jan Mazerski, Pawel Punda, Joanna Wietrzyk
  • ASYMMETRICALLY SUBSTITUTED ANTHRAPYRIDAZONE DERIVATIVES AS CYTOSTATICS
    Publication number: 20140031357
    Abstract: The invention relates to the new, asymmetrically substituted derivatives of 2,7-dihydro-3H-dibenzo[de,h]cinnoline-3,7-dione and their use as cytostatics exhibiting activity against tumor cells, especially against cells with multidrug resistance (MDR). In particular, the invention concerns derivatives of 2,7-dihydro-3H-dibenzo[de,h]cinnoline-3,7-dione represented by the general formula (I).
    Type: Application
    Filed: April 13, 2012
    Publication date: January 30, 2014
    Applicant: BS-154 SP. Z O.O.
    Inventors: Edward Borowski, Barbara Stefanska, Maria Dzieduszycka, Marcin Cybulski, Wieslaw Szelejewski, Janusz Obukowicz, Maria Bontemps-Gracz, Malgorzata Wysocka, Jan Mazerski, Pawel Punda, Joanna Wietrzyk
  • Method of production of polyanionic drug-carrier conjugates
    Patent number: 8623998
    Abstract: The invention concerns the method of production of a polyanionic macromolecule which is a protein built, among others, from polar amino acids such as lysine, arginine, aspartic acid, glutamic acid), characteristic in that, as a result of the reaction between amine groups and the cyclic anhydride of dicarboxylic acid, the charge changes towards more negatively charged carrier. This reaction gives rise to better therapeutic properties of macromolecules modified in this way.
    Type: Grant
    Filed: October 23, 2009
    Date of Patent: January 7, 2014
    Assignee: Instytut Immunologii I Terapii Doswiadczalnej Pan
    Inventors: Janusz Boratyński, Mohamed Salah Omar Megahed, Urszula Kańska, Dmitry Nevozhay, Joanna Wietrzyk
  • COMBINED THERAPY OF COLORECTAL CARCINOMA
    Publication number: 20120101057
    Abstract: The invention relates to a combined therapy, wherein addition of a vitamin D analogue to the standard treatment regimen based on cytostatics, 5-fluorouracil and/or its precursors, generates potential possibility of achieving beneficial therapeutic effect in the first-line chemotherapy or adjuvant therapy of colorectal carcinoma. Vitamin D analogues are selected from a group consisting of tacalcitol, calcipotriol and 5,6-trans-isomer of calcipotriol.
    Type: Application
    Filed: June 9, 2010
    Publication date: April 26, 2012
    Applicant: INSTYTUT FARMACEUTYCZNY
    Inventors: Joanna Wietrzyk, Magdalena Milczarek, Andrzej Kutner, Michal Chodynski
  • METHOD OF PRODUCTION OF POLYANIONIC DRUG-CARRIER CONJUGATES
    Publication number: 20110245466
    Abstract: The invention concerns the method of production of a polyanionic macromolecule which is a protein built, among others, form polar amino acids (such as lysine, arginine, aspartic acid, glutamic acid), characteristic in that, that as a result of the reaction between amine groups and the cyclic anhydride of dicarboxylic acid, the charge changes towards more negatively charged carrier. This reaction gives rise to better therapeutic properties of macromolecules modified in this way.
    Type: Application
    Filed: October 23, 2009
    Publication date: October 6, 2011
    Inventors: Janusz Boratynski, Mohamed Salah Omar Megahed, Urszula Kanska, Dmitry Nevozhay, Joanna Wietrzyk
  • Double helical oligonucleotides interfering with mRNA used as effective anticancer agents
    Publication number: 20090264510
    Abstract: The present invention relates to the application of double-helical oligonucleotides (siRNA) interfering with the mRNA of gene involved in carcinogenesis, particularly the Wnt1, Wnt2 or Her3 genes. Such oligonucleotides may be modified chemically, used in conjunction with viral and non-viral vectors such as lipid complexes. Such oligonucleotides exhibit unusual anti-proliferative properties against tumour cells and may be used in anti-tumour treatment.
    Type: Application
    Filed: July 30, 2008
    Publication date: October 22, 2009
    Inventors: Maciej Wieczorek, Joanna Wietrzyk, Anna Nasulewicz, Katarzyna Szczaurska, Jan Piotr Guzenda, Monika Lamparska-Przyhysz