Abstract: The present invention relates to methods of treating or inhibiting keloids in a subject with hypoxia-inducible factor-1 (HIF-1) inhibiting compounds, methods of screening or identifying compounds to induce cell death in keloids, and methods of inducing cell death in keloids.

Abstract: The present invention relates to methods of treating or inhibiting keloids in a subject with hypoxia-inducible factor-1 (HIF-1) inhibiting compounds, methods of screening or identifying compounds to induce cell death in keloids, and methods of inducing cell death in keloids.

Abstract: An article of water resistant clothing that includes a water resistant underlay layer. The water resistant underlay layer includes at least one compression panel to compress a portion of a body of a user wearing the water resistant clothing. The article of swimwear includes a water resistant overlay layer disposed over the water resistant underlay layer. The water resistant overlay layer exposes at least a portion of the water resistant underlay layer through material of the water resistant overlay layer. The article of water resistant clothing includes a set of fasteners embedded in at least one of the water resistant underlay layer or the water resistant overlay layer to couple the water resistant underlay layer to the water resistant overlay layer.

Abstract: An article of water resistant clothing that includes a water resistant underlay layer. The water resistant underlay layer includes at least one compression panel to compress a portion of a body of a user wearing the water resistant clothing. The article of swimwear includes a water resistant overlay layer disposed over the water resistant underlay layer. The water resistant overlay layer exposes at least a portion of the water resistant underlay layer through material of the water resistant overlay layer. The article of water resistant clothing includes a set of fasteners embedded in at least one of the water resistant underlay layer or the water resistant overlay layer to couple the water resistant underlay layer to the water resistant overlay layer.

Abstract: Bacillus anthracis is a spore-forming Gram positive bacterium that is the causative agent of anthrax infection. Vascular leakage and pleural effusions are hallmarks of the fulminant phase of human anthrax disease following infection. The present invention provides a method of halting, treating, and preventing the rapid toxic effects of human anthrax disease by blocking the VEGF pathway with chemical inhibitors of the VEGFR signaling pathway. The invention is also applicable as an anti-anthrax therapeutic in bio-warfare defense.

Abstract: A tool for removing a seal is provided, wherein the seal has a grooved inner peripheral surface. The tool comprises a tubular member and at least two jaws. The tubular member has inner and outer surfaces, and first and second ends and a passage therebetween. First and second slots are formed between the tubular member inner and outer surfaces, and each equally spaced apart from one another about a predetermined axis. First and a second jaws are at least partially slidably disposed in the first and second slots, respectively, and each jaw has an outer peripheral surface having at least one protrusion formed thereon. The protrusion is configured to mate with the grooved inner peripheral surface. Each jaw is configured to selectively radially expand away from and retract toward the predetermined axis.

Abstract: The present invention relates to novel SH3 domain binding protein, referred to herein a DEF polypeptides. The DEF polypeptides comprise several motifs including a src SH3 consensus binding sequence, four ankyrin repeats, one zinc finger domain and six copies of a proline-rich tandem repeat. DEF polypeptides may function as mediators of SH3 domain-dependent signal transduction pathways and, thus may mediate multiple signaling events such as cellular gene expression, cytoskeletal architecture, protein trafficking and endocytosis, cell adhesion, migration, proliferation and differentiation. Described herein are isolated and antisense nucleic acids molecules, recombinant expression vectors, host cells and non-human transgenic animals containing an insertion or a disruption of the DEF gene.