Patents by Inventor Joanne Conover

Joanne Conover has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Prevention of ES cell differentiation by ciliary neurotrophic factor
    Patent number: 5332672
    Abstract: The present invention provides for a stable, biologically active CNTF/receptor complex, and hybrids or routants thereof. The invention is also based in part on the discovery that the CNTF/receptor complex promotes differentiation through a signal transduction pathway on target cells that do not express the CNTF receptor. The invention further provides for a specific CNTFR mutant that promotes signal transduction without binding CNTF. The invention also provides for a CNTF/receptor blocking mutant, a mutant possessing a high binding affinity to CNTF, but possessing no signal transducing function. The present invention also identifies receptor components shared by the IL-6, CNTF, LIF and OSM signal transduction pathways, and the initiation of signal transduction based upon the presence of such components.
    Type: Grant
    Filed: April 9, 1992
    Date of Patent: July 26, 1994
    Assignee: Regeneron Pharmaceuticals, Inc.
    Inventors: Joanne Conover, George D. Yancopoulos