Patents by Inventor Joanne Murphy-Ullrich

Joanne Murphy-Ullrich has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Piperazine-2,5-diones as TGF-beta inhibitors
    Patent number: 11505531
    Abstract: The present disclosure is concerned with piperazine-2,5-diones that are capable of inhibiting TGF-? and methods of treating cancers such as, for example, multiple myeloma and a hematologic malignancy, and methods of treating fibrotic conditions using these compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Grant
    Filed: August 5, 2019
    Date of Patent: November 22, 2022
    Assignees: UAB RESEARCH FOUNDATION, SOUTHERN RESEARCH INSTITUTE
    Inventors: Mark J. Suto, Vandana V. Gupta, Wei Zhang, Joanne Murphy-Ullrich
  • PIPERAZINE-2,5-DIONES AS TGF-BETA INHIBITORS
    Publication number: 20210323933
    Abstract: The present disclosure is concerned with piperazine-2,5-diones that are capable of inhibiting TGF-? and methods of treating cancers such as, for example, multiple myeloma and a hematologic malignancy, and methods of treating fibrotic conditions using these compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Application
    Filed: August 5, 2019
    Publication date: October 21, 2021
    Applicant: UAB Research Foundation
    Inventors: Mark J. Suto, Vandana V. Gupta, Wei Zhang, Joanne Murphy-Ullrich
  • Dipeptide analogs as TGF-beta inhibitors
    Patent number: 11046729
    Abstract: The present disclosure is concerned with dipeptide analogs that are capable of inhibiting TGF-? and methods of treating cancers such as, for example, multiple myeloma and a hematologic malignancy, methods for immunotherapy, and methods of treating fibrotic conditions using these compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Grant
    Filed: October 26, 2018
    Date of Patent: June 29, 2021
    Assignees: Southern Research Institute, UAB Research Foundation
    Inventors: Mark J. Suto, Vandana Gupta, Bini Mathew, Joanne Murphy-Ullrich
  • Oxadiazoles and thiadiazoles as TGF-? inhibitors
    Patent number: 11033535
    Abstract: The present disclosure is concerned with oxadiazole and thiadiazole analogs that are capable of inhibiting TGF-? and methods of treating cancers such as, for example, multiple myeloma and a hematologic malignancy, and methods of treating fibrotic conditions using these compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Grant
    Filed: March 27, 2020
    Date of Patent: June 15, 2021
    Assignees: Southern Research Institute, UAB Research Foundation
    Inventors: Mark J. Suto, Vandana V. Gupta, Bini Mathew, Joanne Murphy-Ullrich
  • OXADIAZOLES AND THIADIAZOLES AS TGF-BETA INHIBITORS
    Publication number: 20200222371
    Abstract: The present disclosure is concerned with oxadiazole and thiadiazole analogs that are capable of inhibiting TGF-? and methods of treating cancers such as, for example, multiple myeloma and a hematologic malignancy, and methods of treating fibrotic conditions using these compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Application
    Filed: March 27, 2020
    Publication date: July 16, 2020
    Inventors: Mark J. Suto, Vandana V. Gupta, Bini Mathew, Joanne Murphy-Ullrich
  • Oxadiazoles and thiadiazoles as TGF-? inhibitors
    Patent number: 10653682
    Abstract: The present disclosure is concerned with oxadiazole and thiadiazole analogs that are capable of inhibiting TGF-? and methods of treating cancers such as, for example, multiple myeloma and a hematologic malignancy, and methods of treating fibrotic conditions using these compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Grant
    Filed: October 26, 2018
    Date of Patent: May 19, 2020
    Assignees: Southern Research Institute, UAB Research Foundation
    Inventors: Mark J. Suto, Vandana V. Gupta, Bini Mathew, Joanne Murphy-Ullrich
  • DIPEPTIDE ANALOGS AS TGF-BETA INHIBITORS
    Publication number: 20190127420
    Abstract: The present disclosure is concerned with dipeptide analogs that are capable of inhibiting TGF-? and methods of treating cancers such as, for example, multiple myeloma and a hematologic malignancy, methods for immunotherapy, and methods of treating fibrotic conditions using these compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Application
    Filed: October 26, 2018
    Publication date: May 2, 2019
    Inventors: Mark J. Suto, Vandana Gupta, Bini Mathew, Joanne Murphy-Ullrich
  • OXADIAZOLES AND THIADIAZOLES AS TGF-BETA INHIBITORS
    Publication number: 20190125730
    Abstract: The present disclosure is concerned with oxadiazole and thiadiazole analogs that are capable of inhibiting TGF-? and methods of treating cancers such as, for example, multiple myeloma and a hematologic malignancy, and methods of treating fibrotic conditions using these compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Application
    Filed: October 26, 2018
    Publication date: May 2, 2019
    Inventors: Mark J. Suto, Vandana V. Gupta, Bini Mathew, Joanne Murphy-Ullrich
  • THREE-DIMENSIONAL, PREVASCULARIZED, ENGINEERED TISSUE CONSTRUCTS, METHODS OF MAKING AND METHODS OF USING THE TISSUE CONSTRUCTS
    Publication number: 20150212071
    Abstract: Three-dimensional (3D), prevascularized, engineered tissue constructs, 3D prevascularized engineered tissue models of cancer, and bioreactors and bioreactor arrays including the tissue constructs are disclosed. Methods of making the tissue constructs, methods of using the tissue constructs, methods of drug discovery using the tissue constructs and/or cancer models, and the like are also disclosed.
    Type: Application
    Filed: April 3, 2015
    Publication date: July 30, 2015
    Inventors: Joel L. Berry, Timothy M. Wick, Joanne Murphy-Ullrich, Andrew D. Penman, Andrew W. Cain, Andra Rixse Frost
  • Three-dimensional, prevascularized, engineered tissue constructs, methods of making and methods of using the tissue constructs
    Patent number: 9034571
    Abstract: Three-dimensional (3D), prevascularized, engineered tissue constructs, 3D prevascularized engineered tissue models of cancer, and bioreactors and bioreactor arrays including the tissue constructs are disclosed. Methods of making the tissue constructs, methods of using the tissue constructs, methods of drug discovery using the tissue constructs and/or cancer models, and the like are also disclosed.
    Type: Grant
    Filed: March 6, 2013
    Date of Patent: May 19, 2015
    Assignees: THE UAB RESEARCH FOUNDATION, SOUTHERN RESEARCH INSTITUTE
    Inventors: Joel L. Berry, Timothy M. Wick, Joanne Murphy-Ullrich, Andrew D. Penman, Andrew W. Cain, Andra Rixse Frost
  • THREE-DIMENSIONAL, PREVASCULARIZED, ENGINEERED TISSUE CONSTRUCTS, METHODS OF MAKING AND METHODS OF USING THE TISSUE CONSTRUCTS
    Publication number: 20130236879
    Abstract: Embodiments of the present disclosure provide for three-dimensional (3D), prevascularized, engineered tissue constructs, 3D prevascularized engineered tissue models of cancer, and bioreactors and bioreactor arrays including the tissue constructs. The present disclosure also provides methods of making the tissue constructs, methods of using the tissue constructs, methods of drug discovery using the tissue constructs and/or cancer models, and the like.
    Type: Application
    Filed: March 6, 2013
    Publication date: September 12, 2013
    Applicants: SOUTHERN RESEARCH INSTITUTE, THE UAB RESEARCH FOUNDATION
    Inventors: Joel L. Berry, Timothy M. Wick, Joanne Murphy-Ullrich, Andrew D. Penman, Andrew W. Cain