Patents by Inventor Joannes F. M. De Bie

Joannes F. M. De Bie has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Anthracycline compounds and intermediates
    Patent number: 5294701
    Abstract: This invention provides novel anti-tumour compounds of the formula ##STR1## wherein R.sub.1 and R.sub.2 are hydrogen or together form an alkyl-, alkoxy- or OH-substituted aromatic group, which optionally contains an N atom as a hetero-atom; R is --COCH.sub.3 or --C.tbd.C--R.sub.4 and R.sub.4 is H or trimethylsilyl; and R.sub.3 is H or --COCF.sub.3 ; and acid addition salts thereof; as well as compositions containing these compounds.
    Type: Grant
    Filed: May 6, 1992
    Date of Patent: March 15, 1994
    Assignee: Pharmachemie B.V.
    Inventors: Johan W. Scheeren, Joannes F. M. de Bie, Dirk de Vos
  • Trimethylsilyl acetylene compounds, their preparation and their use in the preparation of daunomycinone derivatives
    Patent number: 5079349
    Abstract: The invention relates to novel compounds of the formulae ##STR1## wherein S is H, alkyl or alkoxy and R is a good leaving group, and to the preparation of these compounds in a stereospecific manner to obtain a configuration wherein OH at C-3 and OR at C-1 are in the cis-position, which compounds can be used for the synthesis of daunomycinone and derivatives thereof.Daunomycinone can be used for the preparation of daunomycin and adriamycin.
    Type: Grant
    Filed: February 1, 1990
    Date of Patent: January 7, 1992
    Assignee: Pharmachemie B.V.
    Inventors: Johan W. Scheeren, Joannes F. M. De Bie, Dirk De Vos