Patents by Inventor Joannes Gerardus Theodorus Kierkels

Joannes Gerardus Theodorus Kierkels has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11072805
    Abstract: The invention relates to a two phase fermentation process for producing an organic compound, in particular an isoprenoid and to a bioreactor comprising a two phase fermentation system for producing an organic compound.
    Type: Grant
    Filed: January 25, 2019
    Date of Patent: July 27, 2021
    Inventors: Antonius Cornelis Johannes Matheus Janssen, Joannes Gerardus Theodorus Kierkels, Georg Friedrich Lentzen
  • Patent number: 11041175
    Abstract: The invention relates to a two phase fermentation process for producing an organic compound, in particular an isoprenoid and to a bioreactor comprising a two phase fermentation system for producing an organic compound.
    Type: Grant
    Filed: January 25, 2019
    Date of Patent: June 22, 2021
    Inventors: Antonius Cornelis Johannes Matheus Janssen, Joannes Gerardus Theodorus Kierkels, Georg Friedrich Lentzen
  • Publication number: 20190225994
    Abstract: The invention relates to a two phase fermentation process for producing an organic compound, in particular an isoprenoid and to a bioreactor comprising a two phase fermentation system for producing an organic compound.
    Type: Application
    Filed: January 25, 2019
    Publication date: July 25, 2019
    Inventors: Antonius Cornelis Johannes Matheus JANSSEN, Joannes Gerardus Theodorus KIERKELS, Georg Friedrich LENTZEN
  • Publication number: 20160168595
    Abstract: The invention relates to a two phase fermentation process for producing an organic compound, in particular an isoprenoid and to a bioreactor comprising a two phase fermentation system for producing an organic compound.
    Type: Application
    Filed: July 4, 2014
    Publication date: June 16, 2016
    Inventors: Antonius Cornelis Johannes Matheus JANSSEN, Joannes Gerardus Theodorus KIERKELS, Georg Friedrich LENTZEN
  • Publication number: 20150259705
    Abstract: The invention relates to a Rhodobacter host cell, comprising a nucleic acid encoding—enzymes of a mevalonate pathway for making isoprenyl pyrophosphate (IPP) and its isomer dimethylallyl pyrophosphate (DMAPP);—an enzyme having catalytic activity for the condensation of IPP and DMAPP into geranyl diphosphate (GPP) and—an enzyme having monoterpene synthase activity in the conversion of GPP into a monoterpene or sesquiterpene synthase activity.
    Type: Application
    Filed: July 18, 2013
    Publication date: September 17, 2015
    Inventors: Markus Huembelin, Matrinus Julius Beekwilder, Joannes Gerardus Theodorus Kierkels
  • Patent number: 7713724
    Abstract: The invention relates to isolated polypeptides with hydantoin recemase activity, that do not suffer from substrate inhibition. Such polypeptides arc for instance isolated polypeptides with at least 87% identity with SEQ ID: NO. 2 or SEQ ED: NO. 4. The invention also relates to nucleic acid sequences encoding these polypeptides. The invention also relates to processes for the racemisation of enantiomerically enriched hydantoin compounds and to processes for the preparation of enantiomarically enriched I)-or I-? amino acids.
    Type: Grant
    Filed: May 23, 2003
    Date of Patent: May 11, 2010
    Assignee: DSM IP Assets B.V.
    Inventors: Wilhelmus Hubertus Joseph Boesten, Joannes Gerardus Theodorus Kierkels, Friso Bernard Jan Assema, Luis Miguel Ruiz Pérez, Dolores González Pacanowska, Jesús González López, Santiago De La Escalera Hueso
  • Patent number: 6964863
    Abstract: The invention relates to a process for the preparation of a 2,4-dideoxyhexose or a 2,4,6-trideoxyhexose from a substituted or unsubstituted carbonyl compound with at least 2 carbon atoms and at least one ?-hydrogen atom and a substituted or unsubstituted aldehyde in the presence of an aldolase and water, the reaction between the substituted or unsubstituted carbonyl compound with at least 2 carbon atoms and at least one ?-hydrogen atom and the substituted or unsubstituted aldehyde being carried out at a carbonyl concentration of at most 6 moles/l of reaction mixture and the final concentration of the 2,4-dideoxyhexose or the 2,4,6-trideoxyhexose being at least 2 mass % of the reaction mixture. The invention also relates to the use of a 2,4-dideoxyhexose or a 2,4,6-trideoxyhexose obtained by means of a process according to the invention in the preparation of a medicine, particularly in the preparation of a statine.
    Type: Grant
    Filed: July 9, 2002
    Date of Patent: November 15, 2005
    Assignee: DSM IP Assets B.V.
    Inventors: Joannes Gerardus Theodorus Kierkels, Daniel Mink, Sven Panke
  • Publication number: 20040171125
    Abstract: The invention relates to a process for the preparation of a 2,4-dideoxyhexose or a 2,4,6-trideoxyhexose from a substituted or unsubstituted carbonyl compound with at least 2 carbon atoms and at least one &agr;-hydrogen atom and a substituted or unsubstituted aldehyde in the presence of an aldolase and water, the reaction between the substituted or unsubstituted carbonyl compound with at least 2 carbon atoms and at least one &agr;-hydrogen atom and the substituted or unsubstituted aldehyde being carried out at a carbonyl concentration of at most 6 moles/l of reaction mixture and the final concentration of the 2,4-dideoxyhexose or the 2,4,6-trideoxyhexose being at least 2 mass % of the reaction mixture. The invention also relates to the use of a 2,4-dideoxyhexose or a 2,4,6-trideoxyhexose obtained by means of a process according to the invention in the preparation of a medicine, particularly in the preparation of a statine.
    Type: Application
    Filed: December 19, 2003
    Publication date: September 2, 2004
    Inventors: Joannes Gerardus Theodorus Kierkels, Daniel Mink, Sven Panke