Abstract: Herein is reported a bispecific antibody specifically binding to human Abeta protein and human transferrin receptor (bispecific anti-Abeta/TfR antibody) as well as the use of such bispecific antibodies as a medicament in the treatment of Alzheimer's Disease, including where the bispecific antibody is administered intravenously at a dose of 0.2 mg/kg to 7.2 mg/kg once every four weeks.

Abstract: Systems and processes of distribution of edible products, such as beverages. In particular, a system having a product recipient, a recipient placement disposition operatively associated to an apparatus of distribution of edible products that has a control adapted for control of operation of the distribution of edible products. The apparatus further has an interface operatively associated with the recipient placement disposition and adapted to provide input to the control according to the manipulation of the product recipient, including rotation movement thereof around a reference axis.

Abstract: Cartridges adapted for collecting and supplying single portions of edible substances, the cartridges being adapted for functional connection to apparatus for preparing edible products, such as aromatic beverages, for example espresso type coffee, whereby the cartridges present advantageous configurations of single portions, in particular in the form of previously compacted tablets, and package for collecting these. Systems and processes of operation of systems that include this type of cartridge.

Abstract: The present invention refers to systems of distribution and preparation of edible products, that include cartridges (1, 1?) adapted for collection of single portions (2) of edible substances devoid of single packages, and apparatus (10) for preparation of edible products, such as aromatic beverages, for example espresso type coffee, adapted for operating single portions (2) in product preparation devices (12), for example extraction devices, whereby the systems and processes are adapted so that provide a simpler and more reliable handling of the cartridges (1, 1?) and/or single portions (2), as well as present a simpler construction and provider better ergonomics. The present invention further refers to processes of operation of systems of the type of the present invention.

Abstract: Systems and processes for preparing beverages, in particular espresso coffee and similar aromatic beverages, having at least one type of drinking recipient, for example of glass type, cup or similar, and an apparatus having a beverage discharge disposition operatively associated with a beverage preparation device adapted so that can be driven by a motorized actuation device and collect an individual portion of beverage ingredients. The apparatus has a control mechanism configured so that can process data of several operative parameters of the apparatus, including data relating to the entry of the individual portion in the beverage preparation device and data relating to the position of the actuation device, and being further configured so that can automatically determine the start and end of fluid injection and beverage discharge in a more ergonomic manner.

Abstract: The present invention refers to systems of distribution and preparation of edible products, that include cartridges (1, 1?) adapted for collection of single portions (2) of edible substances devoid of single packages, and apparatus (10) for preparation of edible products, such as aromatic beverages, for example espresso type coffee, adapted for operating single portions (2) in product preparation devices (12), for example extraction devices, whereby these systems present retention means (7) and, optionally, a respective connection disposition (8), adapted so that provide a simpler and more reliable regulation of delivery of single portions (2) one-by-one to said product preparation device (12), as well as present a simpler construction and provider enhanced ergonomics. The present invention further refers to processes of operation of systems of the type of the present invention.

Abstract: Systems and processes for preparing beverages, in particular espresso coffee and similar aromatic beverages, having at least one type of drinking recipient, for example of glass type, cup or similar, and an apparatus having a beverage discharge disposition operatively associated with a beverage preparation device adapted so that can be driven by a motorized actuation device and collect an individual portion of beverage ingredients. The apparatus has a control mechanism configured so that can process data of several operative parameters of the apparatus, including data relating to the entry of the individual portion in the beverage preparation device and data relating to the position of the actuation device, and being further configured so that can automatically determine the start and end of fluid injection and beverage discharge in a more ergonomic manner.

Abstract: Systems and processes for preparing beverages, in particular espresso coffee and similar aromatic beverages, having at least one type of drinking recipient, for example of glass type, cup or similar, and an apparatus having a beverage discharge disposition operatively associated with a beverage preparation device adapted so that can be driven by a motorized actuation device and collect an individual portion of beverage ingredients. The apparatus has a control mechanism that can process data of several operative parameters of the apparatus, including data relating to the entry of the individual portion in said beverage preparation device and data relating to the position of the actuation device, and being further configured to determine actuations of the actuation device and display of progress indications and of operation errors based upon the data of operative parameters.

Abstract: The present invention discloses systems and processes of distribution of edible products, such as for example beverages, in particular a system comprising a product recipient (1, 1?) adapted so that can be operatively placed on a placement disposition (2) that is operatively associated with an apparatus (3) for distribution of edible products that presents control means (5) adapted for controlling the operation of distribution of edible products, whereby said apparatus (3) further presents an interface disposition (7) including an actuation interface (71) associated with said placement disposition (2), and adapted so that provides input to said control means (5) according to the handling of said actuation interface (71), including by means of a contact gesture on a contact surface thereof in a curved or circular-like movement around a reference axis (X).

Abstract: The present invention discloses systems and processes for preparation of edible products, for example aromatic beverages such as espresso coffee and similar, based upon portions (7) of edible substance, for example coffee in a capsule, including an apparatus (1) that comprises a recipient placement disposition (2) adapted for placing a recipient (10, 10?) for collecting edible product, an envelope (3) of apparatus and an access disposition (4) that provides selective access to at least one of said recipient placement disposition (2) and an entry passageway (8) of portions, whereby the cycle of beverage preparation can be carried out by means of apprehension of at least one type of touchless input gesture in the proximal surrounding of the apparatus (1), preferentially in the proximal surrounding of said access disposition (4).

Abstract: The present invention refers to a capsule (1) presenting at least one first construction element (2) configured in a container-like shape, and a second construction element (3) configured in a lid-like shape, adapted so as to contain an individual portion of an edible substance, whereby said second construction element (3) presents a passageway wall (4) that is surrounded in at least most part of respective perimeter by a weakened material region (41) provided as a reduction of thickness in at least one of the upstream and downstream sides of said passageway wall (4), and that presents a projection element (7) adapted so that can be actuated mechanically.

Abstract: A composite pipe termination is provided. The composite pipe includes a composite pipe wall thickness and a cut end. An annular part of composite material is attached around the outside of the composite pipe at the cut end. The annular part has a radial thickness which tapers towards the composite pipe in the direction along the composite pipe away from the cut end to provide an exterior surface having a tapered portion. A pinning structure includes one or more pins which extend through the annular part and partially through the composite pipe wall thickness to further attach the annular part to the composite pipe.

Abstract: Systems and process for preparing beverages, in particular espresso coffee and similar aromatic beverages, based upon a beverage preparation apparatus that has a beverage preparation device adapted to be actuated between open and closed positions by an actuation disposition that includes an electric motor and thereby collect an individual portion of beverage ingredients. A control mechanism is adapted for regulating the operation of several components of the apparatus, to limit the electric power supplied to the electric motor according to at least one previously defined rule along at least most part of the movement path carried out between the open and closed positions.

Abstract: Systems and process for preparing beverages, in particular espresso coffee and similar aromatic beverages, based upon a beverage preparation apparatus that has a beverage preparation device adapted to be actuated between open and closed positions by an actuation disposition that includes an electric motor whose operation can be regulated by a control mechanism, whereby the actuation disposition includes an actuation monitoring mechanism adapted to provide monitoring of the circular movement of a driving cam so that the control mechanism can therewith better regulate the electric power supplied to said electric motor.

Abstract: Beverage preparation systems, in particular espresso coffee and similar aromatic beverages, based upon a beverage preparation apparatus that has a beverage preparation device adapted so that can be actuated between open and closed positions by an actuation disposition that includes an electric motor whose operation can be regulated by a control mechanism, and thereby collect an individual portion of beverage ingredients, whereby the actuation disposition is arranged in advantageous position inside the apparatus and presents enhanced configuration and smaller construction volume.

Abstract: A beverage distribution system for preparation of espresso coffee and similar aromatic beverages, including a drinking recipient (1, 1?), for example of glass, cup, or similar type, a beverage discharge disposition (2) operatively associated with a beverage preparation device (3), whereby the beverage discharge disposition (2) is provided so that the beverage discharge flow impinges, along a direction opposite to the gravity force and with a given flow pressure, and a flow regulation mechanism (13) on the drinking recipient (1, 1?), whereby the drinking recipient (1, 1?) presents a recipient retention mechanism (17) provided so that the drinking recipients (1, 1?) can only be placed on the recipient placement support (22) in one or two previously defined angular extensions with relation to the beverage discharge disposition (2).

Abstract: A capsule (1) having at least one first construction element (2) configured in a container-like shape, and a second construction element (3) configured in a lid-like shape, adapted so as to contain an individual portion of an edible substance. The second construction element (3) presents a passageway wall (4) provided as a recess region and surrounded in at least most part of respective perimeter by a weakened material region (41) provided as a reduction of thickness in the upstream side and downstream side of said passageway wall (4). The capsule is used with an apparatus for preparing edible products comprising at least one brewing device (10) presenting injection means (13) adapted so that exert a mechanic pressure upon the passageway wall (4) on a region of the passageway wall (4) opposite to the region of weakened material region (41).

Abstract: The present invention discloses a beverage discharge disposition comprising a discharge casing (1) configured so that can be provided in the front region of a beverage preparation machine (20), including the option of supplying milk and frothed milk, whereby said discharge casing (1) presents a milk circulation disposition (2) adapted so as to provide an ergonomic use of a beverage preparation machine, in particular the possibility of dismounting and mounting said milk circulation disposition (2) for periodic cleaning thereof. The present invention further discloses a beverage preparation machine (20) and a process for operating said machine (20), in particular of a respective ergonomic beverage discharge disposition, according to the present invention.

Abstract: A beverage distribution system for preparation of espresso coffee and similar aromatic beverages, including a drinking recipient (1, 1?), for example of type glass, cup, or similar, a beverage discharge disposition (2) operatively associated with a beverage preparation device (3), whereby the beverage discharge disposition is provided so that the beverage discharge flow impinges, with a given flow pressure, a flow regulation disposition (12) on the base region (11) of the drinking recipient (1, 1?) along a direction opposite gravity, whereby the drinking recipient has first and second recipient parts (11, 12) adapted to be removably retained and that, in an assembled condition, provide fluid connection through a flow passageway (110) that develops along a single direction and to confine the beverage flow downstream of flow constrain means (16) and upstream of the entry of beverage flow in the region of the base wall (111) of the collection space.

Abstract: The present invention discloses a machine (1) for preparing beverages, in particular aromatic beverages such as for example espresso type coffee, comprising a machine casing (2) that presents at least one first access element (21) on a lateral face of said machine casing (2), adapted so that provides access to the interior region where there are the fluid pressurization means (5), preferentially also a second element access (22) also on a lateral face of said machine casing (2), adapted so that provides access to the interior region where there is provided a milk frothing device (9), thereby enabling its removal for periodic cleaning in ergonomic manner.