Patents by Inventor Joao Antonio Lourenco Goncalves

Joao Antonio Lourenco Goncalves has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Therapeutic splice-switching oligonucleotides
    Patent number: 11427821
    Abstract: The present disclosure provides compositions and methods for treating a disorder associated with mutations in the CEP290 gene. The disclosure includes synthetic polynucleotides for skipping a reading-frame of a CEP290 pre-RNA, yielding a CEP290 translated product that lacks one or more exons. The disclosure also provides methods of treating patients with the synthetic polynucleotides disclosed herein.
    Type: Grant
    Filed: January 30, 2020
    Date of Patent: August 30, 2022
    Assignee: DEEP GENOMICS INCORPORATED
    Inventors: Daniele Merico, Joao Antonio Lourenco Goncalves, Erno Wienholds, Mark George Ford Sun
  • THERAPEUTIC SPLICE-SWITCHING OLIGONUCLEOTIDES
    Publication number: 20200165611
    Abstract: The present disclosure provides compositions and methods for treating a disorder associated with mutations in the CEP290 gene. The disclosure includes synthetic polynucleotides for skipping a reading-frame of a CEP290 pre-RNA, yielding a CEP290 translated product that lacks one or more exons. The disclosure also provides methods of treating patients with the synthetic polynucleotides disclosed herein.
    Type: Application
    Filed: January 30, 2020
    Publication date: May 28, 2020
    Inventors: Daniele Merico, Joao Antonio Lourenco Goncalves, Erno Wienholds, Mark George Ford Sun