Publication number: 20220401402
Abstract: The present invention relates to a composition for use in preventing migration of cancer cells in a subject known or suspected to suffer from cancer, the composition comprising at least one metal complex having the structure (I), formula (I), wherein M is a metal, preferably selected from the group consisting of copper, iron, manganese and zinc, X is Xa or Xb, wherein Xa is selected from the group consisting of O, S and —N(R1)—, wherein R1 is H or alkyl, and wherein Xb is a group forming a coordinate covalent bond to a second metal M?, preferably a group O, S or —N(R1)—, wherein M? is preferably selected from the group consisting of copper, iron, manganese and zinc, and wherein M? and M may be the same or different and are preferably the same, Z1 and Z2 are independently of each other a, substituted or unsubstituted, -Aryl-O—, -Aryl-N— or heteroaryl group, Y is Ya or Yb, wherein Ya is selected from the group consisting of H, alkyl, —OH, —SH, halogen, and —NR3R4, wherein R3 and R4, are independently of each ot
Type:
Application
Filed:
October 2, 2020
Publication date:
December 22, 2022
Applicant:
Deutsches Krebsforschungszentrum
Inventors:
Joao SECO, Joana Filipa GUERREIRO, Marco GOMES, Adolfo HORN, Christiane Femandes HORN, Francesca PAGLIARI