Patents by Inventor Job Harenberg

Job Harenberg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210317505
    Abstract: The present invention relates to the use of excitation light having a wavelength in the range of 370 nm to 390 nm for detecting at least one anticoagulant in a sample, wherein the sample is derived from a body fluid and does not contain citrated blood plasma, and to a method related thereto.
    Type: Application
    Filed: July 25, 2018
    Publication date: October 14, 2021
    Inventor: Job HARENBERG
  • Publication number: 20180215787
    Abstract: The present invention relates to chromogenic and fluorogenic substrates that can be used for the highly sensitive and selective detection of the activity of serine proteases. The present invention further relates to methods for the detection of the activity of serine proteases, said methods using the substrates of the present invention. Furthermore, the present invention relates to diagnostic kits and test strips using the above substrates, as well as uses of said substrates.
    Type: Application
    Filed: August 3, 2016
    Publication date: August 2, 2018
    Inventors: Roland Krämer, Dumitru Arian, Job Harenberg
  • Patent number: 9944971
    Abstract: The present invention relates to a method for detecting at least one direct thrombin inhibitor in a sample other than citrate plasma, comprising the step of mixing a sample containing a thrombin inhibitor with a composition containing thrombin under conditions which allow the thrombin to release a detectable substance from a chromogenic substrate.
    Type: Grant
    Filed: June 15, 2012
    Date of Patent: April 17, 2018
    Assignee: DOASENSE GmbH
    Inventors: Job Harenberg, Roland Kramer
  • Patent number: 9897617
    Abstract: The present invention relates to a method for detecting at least one direct factor Xa inhibitor in a sample other than citrate plasma, comprising the step of mixing a sample containing a factor Xa inhibitor with a composition containing factor Xa under conditions which allow the factor Xa to release a detectable substance from a chromogenic substrate.
    Type: Grant
    Filed: August 11, 2015
    Date of Patent: February 20, 2018
    Assignee: Doasense GmbH
    Inventors: Job Harenberg, Roland Krämer
  • Patent number: 9810701
    Abstract: The present invention relates to a method for detecting at least one direct factor Xa inhibitor in a sample other than citrate plasma, comprising the step of mixing a sample containing a factor Xa inhibitor with a composition containing factor Xa under conditions which allow the factor Xa to release a detectable substance from a chromogenic substrate.
    Type: Grant
    Filed: August 11, 2015
    Date of Patent: November 7, 2017
    Assignee: Doasense GmbH
    Inventors: Job Harenberg, Roland Krämer
  • Publication number: 20160011218
    Abstract: The present invention relates to a method for detecting at least one direct factor Xa inhibitor in a sample other than citrate plasma, comprising the step of mixing a sample containing a factor Xa inhibitor with a composition containing factor Xa under conditions which allow the factor Xa to release a detectable substance from a chromogenic substrate.
    Type: Application
    Filed: August 11, 2015
    Publication date: January 14, 2016
    Inventors: Job Harenberg, Roland Krämer
  • Publication number: 20150344935
    Abstract: The present invention relates to a method for detecting at least one direct factor Xa inhibitor in a sample other than citrate plasma, comprising the step of mixing a sample containing a factor Xa inhibitor with a composition containing factor Xa under conditions which allow the factor Xa to release a detectable substance from a chromogenic substrate.
    Type: Application
    Filed: August 11, 2015
    Publication date: December 3, 2015
    Inventors: Job Harenberg, Roland Krämer
  • Patent number: 9133501
    Abstract: The present invention relates to a method for detecting at least one direct factor Xa inhibitor in a sample other than citrate plasma, comprising the step of mixing a sample containing a factor Xa inhibitor with a composition containing factor Xa under conditions which allow the factor Xa to release a detectable substance from a chromogenic substrate.
    Type: Grant
    Filed: November 7, 2011
    Date of Patent: September 15, 2015
    Assignee: Ruprecht-Karls-Universität Heidelberg
    Inventors: Job Harenberg, Roland Krämer
  • Patent number: 9006261
    Abstract: The invention relates to a perylene diimide derivative and to an in vitro method for preparing the same. In addition, the invention relates to a method for detecting heparin in a sample using perylene diimide derivatives, wherein the interaction of the perylene diimide derivative with heparin modulates the intensity of the fluorescent signal of the mixture compared to the solution. The invention also comprises a diagnostic kit for detecting heparin in a sample in vitro, comprising the perylene diimide derivative, as well as the use of the perylene diimide derivative for neutralizing the anticoagulant activity of heparin.
    Type: Grant
    Filed: August 19, 2010
    Date of Patent: April 14, 2015
    Inventors: Roland Kraemer, Helga Szelke, Job Harenberg, Armin Poeck
  • Publication number: 20140220611
    Abstract: The present invention relates to a method for detecting at least one direct thrombin inhibitor in a sample other than citrate plasma, comprising the step of mixing a sample containing a thrombin inhibitor with a composition containing thrombin under conditions which allow the thrombin to release a detectable substance from a chromogenic substrate.
    Type: Application
    Filed: June 15, 2012
    Publication date: August 7, 2014
    Inventors: Job Harenberg, Roland Kramer
  • Publication number: 20130302839
    Abstract: The present invention relates to a method for detecting at least one direct factor Xa inhibitor in a sample other than citrate plasma, comprising the step of mixing a sample containing a factor Xa inhibitor with a composition containing factor Xa under conditions which allow the factor Xa to release a detectable substance from a chromogenic substrate.
    Type: Application
    Filed: November 7, 2011
    Publication date: November 14, 2013
    Applicant: UNIVERSITAT HEIDELBERG
    Inventors: Job Harenberg, Roland Krämer
  • Publication number: 20120220617
    Abstract: The invention relates to a perylene diimide derivative and to an in vitro method for preparing the same. In addition, the invention relates to a method for detecting heparin in a sample using perylene diimide derivatives, wherein the interaction of the perylene diimide derivative with heparin modulates the intensity of the fluorescent signal of the mixture compared to the solution. The invention also comprises a diagnostic kit for detecting heparin in a sample in vitro, comprising the perylene diimide derivative, as well as the use of the perylene diimide derivative for neutralizing the anticoagulant activity of heparin.
    Type: Application
    Filed: August 19, 2010
    Publication date: August 30, 2012
    Inventors: Roland Kraemer, Helga Szelke, Job Harenberg, Armin Poeck